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Search: authors:"Yoshiki Nakashima"

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Characterization of induced tissue-specific stem cells from pancreas by a synthetic self-replicative RNA

Miyagi-Shiohira, Yoshiki Nakashima & Hirofumi NoguchiOkayama Saidaiji Hospital, Okayama, 704-8192, JapanNaoya KobayashiDivision of Pediatric Dentistry, Graduate School of Medical and Dental Science ... AuthorsSearch for Chika Miyagi-Shiohira in:Nature Research journals • PubMed • Google Scholar Search for Yoshiki Nakashima in:Nature Research journals • PubMed • Google Scholar Search for Naoya Kobayashi

Stimulation of Osteoclast Formation by RANKL Requires Interferon Regulatory Factor-4 and Is Inhibited by Simvastatin in a Mouse Model of Bone Loss

Diseases of bone loss are a major public health problem. Here, we report the novel therapeutic action of simvastatin in osteoclastogenesis and osteoprotection, demonstrated by the ability of simvastatin to suppress osteoclast formation in vitro and in vivo. We found that in vitro, IRF4 expression is upregulated during osteoclast differentiation induced by RANKL (receptor...