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Search: authors:"Yoshiko Iwai"

6 papers found.
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Cancer immunotherapies targeting the PD-1 signaling pathway

Immunotherapy has recently emerged as the fourth pillar of cancer treatment, joining surgery, radiation, and chemotherapy. While early immunotherapies focused on accelerating T-cell activity, current immune-checkpoint inhibitors take the brakes off the anti-tumor immune responses. Successful clinical trials with PD-1 monoclonal antibodies and other immune-checkpoint inhibitors have ...

Activation of fibroblast-like synoviocytes derived from rheumatoid arthritis via lysophosphatidic acid�lysophosphatidic acid receptor 1 cascade

Introduction Lysophosphatidic acid (LPA) is a bioactive lipid that binds to G protein�coupled receptors (LPA1�6). Recently, we reported that abrogation of LPA receptor 1 (LPA1) ameliorated murine collagen-induced arthritis, probably via inhibition of inflammatory cell migration, Th17 differentiation and osteoclastogenesis. In this study, we examined the importance of the LPA�LPA1 ...

Role of WNT10A-Expressing Kidney Fibroblasts in Acute Interstitial Nephritis

Acute Interstitial Nephritis Akihiro Kuma Sohsuke Yamada Ke-Yong Wang Noriaki Kitamura Takahiro Yamaguchi Yoshiko Iwai Hiroto Izumi Masahito Tamura Yutaka Otsuji Kimitoshi Kohno Robert Dettman

PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells

Since metastasis is the major cause of death for cancer patients, there is an urgent need to develop new therapies to control hematogenous dissemination of cancer cells. Previously we and others demonstrated a novel mechanism that allows tumors to escape from the host immune response by expressing PD-L1 which can negatively regulate immune response through the interaction with ...

An IFN-γ-IL-18 Signaling Loop Accelerates Memory CD8+ T Cell Proliferation

Rapid proliferation is one of the important features of memory CD8+ T cells, ensuring rapid clearance of reinfection. Although several cytokines such as IL-15 and IL-7 regulate relatively slow homeostatic proliferation of memory T cells during the maintenance phase, it is unknown how memory T cells can proliferate more quickly than naïve T cells upon antigen stimulation. To examine ...