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17 papers found.
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Chloroquine augments TRAIL-induced apoptosis and induces G2/M phase arrest in human pancreatic cancer cells

Monma, Yoshitsugu Tajima, Mamoru Harada. Data curation: Hiroyuki Monma, Mamoru Harada. Formal analysis: Hiroyuki Monma. Funding acquisition: Mamoru Harada. Investigation: Hiroyuki Monma, Yuichi Iida ... , Tamami Moritani, Tamio Okimoto, Mamoru Harada. Methodology: Ryosuke Tanino. Supervision: Yoshitsugu Tajima, Mamoru Harada. Writing ± original draft: Hiroyuki Monma, Mamoru Harada. Writing ± review

Preoperative Prognostic Nutritional Index Predicts Long-Term Surgical Outcomes in Patients with Esophageal Squamous Cell Carcinoma

Background The purpose of the present study is to investigate the utility of prognostic nutritional index (PNI) as a simple and readily available marker in esophageal squamous cell carcinoma (ESCC). Methods We retrospectively analyzed 169 patients who underwent potentially curative esophagectomy, for histologically verified ESCC. We decided to set the optimal cutoff value for...

A Novel Prognostic Scoring System Using Inflammatory Response Biomarkers for Esophageal Squamous Cell Carcinoma

. Compliance with ethical standards Conflict of interest Noriyuki Hirahara, Yoshitsugu Tajima, Yusuke Fujii, Tetsu Yamamoto, Ryoji Hyakudomi, Takanori Hirayama, Takahito Taniura, Kazunari Ishitobi, Akihiko

Prognostic value of preoperative inflammatory response biomarkers in patients with esophageal cancer who undergo a curative thoracoscopic esophagectomy

Background Several inflammatory response biomarkers, including lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) have been reported to predict survival in various cancers. The aim of this study is to evaluate the clinical value of these biomarkers in patients undergoing curative resection for esophageal cancer...

Prognostic value of hematological parameters in patients undergoing esophagectomy for esophageal squamous cell carcinoma

Mizota Shuichi Ishibashi Yoshitsugu Tajima Background It is now widely recognized that outcomes in cancer patients are not determined by their tumor characteristics alone. In this study, we

Intraductal papillary mucinous carcinoma of the pancreas associated with pancreas divisum: a case report and review of the literature

Kawabata 0 Noriyoshi Ishikawa Asuka Araki Seiji Yano 0 Riruke Maruyama Yoshitsugu Tajima 0 0 Department of Digestive and General Surgery, Shimane University Faculty of Medicine , 89-1 Enyacho, Izumo, Shimane

Significance of prophylactic intra-abdominal drain placement after laparoscopic distal gastrectomy for gastric cancer

cases. The authors received the generous support and encouragement of Yoshitsugu Tajima in correcting the English used in this manuscript. 1. Mangram AJ , Horan TC , Pearson ML , Siver LC , Jarvis WR

A case of male inflammatory breast cancer

This report describes the case of an 85-year-old male with inflammatory breast cancer. The patient presented with diffuse erythema and induration over the right anterior chest wall. Ultrasonography and mammography demonstrated an ill-defined small mass, 8 mm in diameter, in the right breast with skin thickening. A core needle biopsy of the breast mass confirmed the presence of...

Secure hemostasis in transhiatal esophagectomy for esophageal cancer with gauze packing

Wake 0 Yoshitsugu Tajima 0 0 Department of Digestive and General Surgery, Shimane University Faculty of Medicine , 89-1 Enya-cho, Izumo, Shimane 693-8501 , Japan Background: Transhiatal esophagectomy

A case of pancreatic neuroendocrine tumor in a patient with neurofibromatosis-1

Patients with neurofibromatosis-1 (NF-1) sometime develop neuroendocrine tumors (NET). Although these NETs usually occur in the duodenum or peri-ampullary region, they occasionally grow in the pancreas (PNET). A 62-year-old man with NF-1 had mild liver dysfunction and was admitted to our hospital for further examination. An abdominal contrast-enhanced computed tomography scan...

Regeneration of Graft Livers and Limited Contribution of Extrahepatic Cells After Partial Liver Transplantation in Humans

Background Liver regeneration is still not fully understood. Partial liver transplantation (LT) can provide the opportunity to investigate the mechanisms of liver regeneration, including the contribution of extrahepatic cells to liver regeneration. Methods Of 61 patients transplanted with partial liver graft between August 1997 and October 2006, 56 patients were studied...

Chemopreventative effect of an inducible nitric oxide synthase inhibitor, ONO-1714, on inflammation-associated biliary carcinogenesis in hamsters

The present study was designed to investigate whether an inducible nitric oxide synthase (iNOS)-specific inhibitor, ONO-1714 [(1S, 5S, 6R, 7R)-7-chloro-3-imino-5-methyl-2-azabicyclo[4.1.0] heptane], could prevent inflammation-associated biliary carcinogenesis in bilioenterostomized hamsters. Syrian golden hamsters underwent choledochojejunostomy and then received subcutaneous...

Chemopreventive effects of a selective cyclooxygenase-2 inhibitor (etodolac) on chemically induced intraductal papillary carcinoma of the pancreas in hamsters

The present study was designed to determine whether etodolac, a selective cyclooxygenase-2 inhibitor, prevents chemically induced intraductal papillary carcinoma (IPC) in the main pancreatic duct of hamsters. Hamsters were subjected to cholecystoduodenostomy with dissection of the distal end of the common duct. Four weeks after surgery, the surviving hamsters received...

Chemopreventative effect of a cyclooxygenase-2-specific inhibitor (etodolac) on chemically induced biliary carcinogenesis in hamsters

The present study was designed to evaluate whether etodolac, a cyclooxgenase-2 (COX-2)-specific inhibitor, could prevent chemically induced biliary carcinogenesis in bilioenterostomized hamsters. Syrian golden hamsters were subjected to choledochojejunostomy and then received subcutaneous injections of N-nitrosobis(2-oxopropyl)amine (BOP) every 2 weeks at a dose of 10 mg/kg body...

Acceleration of spontaneous biliary carcinogenesis in hamsters by bilioenterostomy

Biliary carcinomas can occur as a delayed complication of bilioenterostomy. The aim of this study was to determine whether bilioenterostomy influences biliary carcinogenesis in hamsters. Syrian hamsters were subjected to three different surgical procedures: simple laparotomy (SL), choledochoduodenostomy (CD) and choledochojejunostomy (CJ). They were given no carcinogens, and five...

Comparative analysis of Helicobacter DNAs and biliary pathology in patients with and without hepatobiliary cancer

Several Helicobacter species have recently been isolated from the bile and hepatobiliary systems of murine species, and are well recognized as a pathogen of the hepatobiliary disorder. This study was planned to investigate whether Helicobacter species possess a causative potential for human hepatobiliary disease, especially for hepatobiliary carcinogenesis. Bile and hepatobiliary...

CARCINOGENESIS: Bilioenterostomy enhances biliary carcinogenesis in hamsters

The aim of this study was to examine whether the type of bilioenterostomy enhances biliary carcinogenesis in the hamster model. Syrian hamsters were divided into the following groups; simple laparotomy (control group), cholecystoduodenostomy with dissection of the extrahepatic bile duct on the distal end of the common duct (CDDB group) and cholecystoileostomy with dissection of...