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74 papers found.
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G.A.M.E.: GPU-accelerated mixture elucidator

GPU acceleration is useful in solving complex chemical information problems. Identifying unknown structures from the mass spectra of natural product mixtures has been a desirable yet unresolved issue in metabolomics. However, this elucidation process has been hampered by complex experimental data and the inability of instruments to completely separate different compounds. ...

Modulation the alternative splicing of GLA (IVS4+919G>A) in Fabry disease

While a base substitution in intron 4 of GLA (IVS4+919G>A) that causes aberrant alternative splicing resulting in Fabry disease has been reported, its molecular mechanism remains unclear. Here we reported that upon IVS4+919G>A transversion, H3K36me3 was enriched across the alternatively spliced region. PSIP1, an adapter of H3K36me3, together with Hsp70 and NONO were recruited and ...

Role of CYP2E1 polymorphisms in breast cancer: a systematic review and meta-analysis

Background CYP2E1 polymorphisms have been reported to influence individual’s breast cancer susceptibility as a phase I enzyme, but the results of these previous studies remain controversial. We performed a comprehensive meta-analysis to assess their association. Methods A comprehensive search of literature included in various databases (PubMed, Web of Science and Google scholar), ...

Antitumor activity of TY-011 against gastric cancer by inhibiting Aurora A, Aurora B and VEGFR2 kinases

Background Overexpression of Aurora A and B has been reported in a wide range of tumor types, including gastric cancer. Anti-angiogenesis has been considered as an important therapeutic modality in advanced gastric cancer. Here we identified a novel compound TY-011 with promising antitumor activity by targeting mitotic kinases (Aurora A and B) and angiogenic receptor tyrosine ...

Centrosome/Cell Cycle Uncoupling and Elimination in the Endoreduplicating Intestinal Cells of C. elegans

The centrosome cycle is most often coordinated with mitotic cell division through the activity of various essential cell cycle regulators, consequently ensuring that the centriole is duplicated once, and only once, per cell cycle. However, this coupling can be altered in specific developmental contexts; for example, multi-ciliated cells generate hundreds of centrioles without any ...

Application of SNPscan in Genetic Screening for Common Hearing Loss Genes

The current study reports the successful application of a fast and efficient genetic screening system for common hearing loss (HL) genes based on SNPscan genotyping technology. Genetic analysis of 115 variants in common genes related to HL, GJB2, SLC26A4 and MT-RNR, was performed on 695 subjects with non-syndromic hearing loss (NSHL) from the Northern China. The results found that ...

Evaluation of the necessity for chest drain placement following thoracoscopic wedge resection

Purpose To evaluate the outcomes of patients who underwent thoracoscopic wedge resection without chest drain placement. Methods The subjects of this retrospective study were 89 patients, who underwent thoracoscopic wedge resection at our hospital between January, 2013 and July, 2015. A total of 45 patients whose underlying condition did not meet the following criteria were assigned ...

Ubiquitylation of Rad51d Mediated by E3 Ligase Rnf138 Promotes the Homologous Recombination Repair Pathway

Ubiquitylation has an important role as a signal transducer that regulates protein function, subcellular localization, or stability during the DNA damage response. In this study, we show that Ring domain E3 ubiquitin ligases RNF138 is recruited to DNA damage site quickly. And the recruitment is mediated through its Zinc finger domains. We further confirm that RNF138 is ...

A meshless method based on moving least squares for the simulation of free surface flows

by the National Natural Science Foundation of China (Nos. 51379040 and 51409063) ORCID: Yu LU In this paper, a meshless method based on moving least squares (MLS) is presented to simulate free surface

The relationship between glasgow prognostic score and serum tumor markers in patients with advanced non-small cell lung cancer

Background Glasgow Prognostic Score (GPS) has been reported as a powerful prognostic tool for patients with advanced non–small cell lung cancer (NSCLC). The aim of this study was to assess the relationship between GPS and prognosis related tumor markers in patients with advanced NSCLC. Methods We included 138 advanced NSCLC patients and twenty healthy controls in the study. GPS was ...

情色/色情 : 專訪電影監製蕭定一

近年,環球和香港電影市場興起3D電影(立體影像),這無疑令本港電影市道再掀起一股熱潮。不過,流行歸流行,終究你會發現某些3D電影是多此一舉、畫蛇添足,其實不用帶上那副令人有點頭暈的3D眼鏡觀賞會更好,反正有些電影立體不立體都不是重點。最近,本地上影成人電影《3D肉蒲團之極樂寶鑑》,開拍這部電影的是中國3D數碼娛樂有限公司掌舵人蕭定一。

Factors affecting number of lymph nodes harvested and the impact of examining a minimum of 12 lymph nodes in stage I-III colorectal cancer patients: a retrospective single institution cohort study of 1167 consecutive patients

Background To identify factors affecting the harvest of lymph nodes (LNs) and to investigate the association between examining a minimum of 12 LNs and clinical outcomes in stage I-III colorectal cancer (CRC) patients. Methods The clinicopathologic features and the number of examined LNs for 1167 stage I-III CRC patients were analyzed to identify factors affecting the number of LNs ...

Multiscale Entropy of Electroencephalogram as a Potential Predictor for the Prognosis of Neonatal Seizures

Objective Increasing animal studies supported the harmful effects of prolonged or frequent neonatal seizures in developing brain, including increased risk of later epilepsy. Various nonlinear analytic measures had been applied to investigate the change of brain complexity with age. This study focuses on clarifying the relationship between later epilepsy and the changes of ...

Low-frequency electroacupuncture suppresses focal epilepsy and improves epilepsy-induced sleep disruptions

Background The positive effects of acupuncture at Feng-Chi acupoints on treating epilepsy and insomnia have been well-documented in ancient Chinese literature. However, there is a lack of scientific evidence to elucidate the underlying mechanisms behind these effects. Our previous study demonstrated that high-frequency (100 Hz) electroacupuncture (EA) at Feng-Chi acupoints ...

Feasibility of diagnosing unstable plaque in patients with acute coronary syndrome using iMap-IVUS

plaque. Compliance with ethics guidelines Jian LIU, Zhao WANG, Wei-min WANG, Qi LI, Yu-liang MA, Chuan-fen LIU, Ming-yu LU, and Hong ZHAO declare that they have no conflict of interest. All procedures

Interferon Gamma +874T/A Polymorphism Increases the Risk of Hepatitis Virus-Related Diseases: Evidence from a Meta-Analysis

: interferon, IFN polymorphism, polymorphisms, mutation, variant, hepatitis, cirrhosis, and hepatocellular carcinoma. Two investigators (Yifan Sun and Yu Lu) conducted an extensive independent literature search ... extraction Two investigators (Yifan Sun and Yu Lu) independently extracted data from the included studies. The data included the first authors name, publication date, country, ethnicity, total sample size

Interferon gamma polymorphisms and hepatitis B virus-related liver cirrhosis risk in a Chinese population

and Yu Lu should be considered as the co-first authors. 1. Chen JG , Zhang SW . Liver cancer epidemic in China: past, present and future . Semin Cancer Biol . 2011 ; 21 : 59 - 69 . 2. Ganem D , Prince

Association between IL-18 polymorphisms, serum levels, and HBV-related hepatocellular carcinoma in a Chinese population: a retrospective case–control study

Background Interleukin (IL)-18 gene polymorphisms have been found to play multiple roles in various diseases. However, studies focused on its involvement in hepatocellular carcinoma (HCC) remains controversial, and no much study has taken IL-18 serum levels into consideration. This study investigates the association between IL-18 polymorphisms and risk of hepatitis B virus-related ...