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Is exclusion of leukocytes from platelet-rich plasma (PRP) a better choice for early intervertebral disc regeneration?

BackgroundPlatelet-rich plasma (PRP) is becoming a promising strategy to treat early intervertebral disc degeneration (IDD) in clinics. Pure PRP without leukocytes (P-PRP) may decrease the catabolic and inflammatory changes in the early degenerated intervertebral discs. The aim of this study was to investigate the effects of P-PRP on nucleus pulposus-derived stem cells (NPSCs...

Overexpression of the transcription factor NF-YC9 confers abscisic acid hypersensitivity in Arabidopsis

signaling; Arabidopsis thaliana; Nuclear factor NF-YC9; ABA-INSENSITIVE5 (ABI5); Seedling growth; Stomata - Chao Bi and Yu Ma have contributed equally to this work. Introduction The phytohormone abscisic

Efficacy and long-term longitudinal follow-up of bone marrow mesenchymal cell transplantation therapy in a diabetic patient with recurrent lower limb bullosis diabeticorum

Bullosis diabeticorum is a rare presentation of cutaneous manifestation most commonly affecting the lower limbs in patients with diabetes. The appearance, often as insidious as its resolution, is characterized by tense blisters on the skin surfaces of the lower limbs and the feet. The cause still remains unclear, but it may relate to microangiopathy and neuropathy. In this report...

Regeneration of functional alveoli by adult human SOX9+ airway basal cell transplantation

; transplantation; stem cell; bronchiectasis; alveoli - Qiwang Ma, Yu Ma, Xiaotian Dai, and Tao Ren have contributed equally to this work. human lung structure can be reconstituted by orthotopic transplantation of ... Zhong for helpful discussion of this work, and thank Profs. Xiaoqing Zhang, Long Zhang and Huiping Li for reagents help. COMPLIANCE WITH ETHICS GUIDELINES Qiwang Ma, Yu Ma, Xiaotian Dai, Tao Ren

Variability in daily activity-travel patterns: the case of a one-week travel diary

Introduction Understanding temporal rhythms in travel and activity patterns has been recognized as an important issue for the effective management of urban congestion. Research issues related to this topic concern the degree to which travel behaviour varies from one day to another, the differences between weekday and weekend travel, and the determinants of variability. Thanks to...

Verrucosispora rhizosphaerae sp. nov., isolated from mangrove rhizosphere soil

An actinomycete strain, 2603PH03T, was isolated from a mangrove rhizosphere soil sample collected in Wenchang, China. Phylogenetic analysis of the 16S rRNA gene sequence of strain 2603PH03T indicated high similarity to Verrucosispora gifthornensis DSM 44337T (99.4%), Verrucosispora andamanensis (99.4%), Verrucosispora fiedleri MG-37T (99.4%) and Verrucosispora maris AB18-032T (99...

Arabidopsis ABI5 plays a role in regulating ROS homeostasis by activating CATALASE 1 transcription in seed germination

It has been known that ABA INSENSITIVE 5 (ABI5) plays a vital role in regulating seed germination. In the present study, we showed that inhibition of the catalase activity with 3-amino-1,2,4-triazole (3-AT) inhibits seed germination of Col-0, abi5 mutants and ABI5-overexpression transgenic lines. Compared with Col-0, the seeds of abi5 mutants showed more sensitive to 3-AT during...

Protocol for management after thyroidectomy: a retrospective study based on one-center experience

Protocol for management after thyroidectomy: a retrospective study based on one-center experience Han Luo,1 Hongliu Yang,2,3 Tao Wei,1 Yanping Gong,1 Anping Su,1 Yu Ma,1 Xiuhe Zou,1 Jianyong Lei,1

DNA Double-Strand Breaks Induce the Nuclear Actin Filaments Formation in Cumulus-Enclosed Oocytes but Not in Denuded Oocytes

As a gamete, oocyte needs to maintain its genomic integrity and passes this haploid genome to the next generation. However, fully-grown mouse oocyte cannot respond to DNA double-strand breaks (DSBs) effectively and it is also unable to repair them before the meiosis resumption. To compensate for this disadvantage and control the DNA repair events, oocyte needs the cooperation...

Comparative proteomic analysis provides novel insight into the interaction between resistant vs susceptible tomato cultivars and TYLCV infection

Background Tomato yellow leaf curl virus (TYLCV) is a member of the family Geminiviridae, genus Begomovirus. The virus is a widespread plant virus that causes important economic losses in tomatoes. Genetic engineering strategies have increasingly been adopted to improve the resistance of tomatoes to TYLCV. Results In this study, a proteomic approach was used to investigate the...

Cumulus Cells Block Oocyte Meiotic Resumption via Gap Junctions in Cumulus Oocyte Complexes Subjected to DNA Double-Strand Breaks

During mammalian oocyte growth, genomic DNA may accumulate DNA double-strand breaks (DSBs) induced by factors such as reactive oxygen species. Recent evidence demonstrated that slight DSBs do not activate DNA damage checkpoint proteins in denuded oocytes. These oocytes, even with DNA DSBs, can resume meiosis and progress to metaphase of meiosis II. Meiotic resumption in oocytes...

Rapid increase of scrub typhus incidence in Guangzhou, southern China, 2006―2014

Background In the last decade, scrub typhus (ST) has been emerging or re-emerging in some areas of Asia, including Guangzhou, one of the most affected endemic areas of ST in China. Methods Based on the data on all cases reported in Guangzhou from 2006 to 2014, we characterized the epidemiological features, and identified environmental determinants for the spatial distribution of...

Positive Solutions for the Initial Value Problems of Fractional Evolution Equation

This paper discusses the existence of positive solutions for the initial value problem of fractional evolution equation with noncompact semigroup , ; in a Banach space , where denotes the Caputo fractional derivative of order , is a closed linear operator, generates an equicontinuous semigroup, and is continuous. In the case where satisfies a weaker measure of noncompactness...

High-Density Genetic Linkage Mapping in Turbot (Scophthalmus maximus L.) Based on SNP Markers and Major Sex- and Growth-Related Regions Detection

This paper describes the development of a high density consensus genetic linkage map of a turbot (Scophthalmus maximus L.) family composed of 149 mapping individuals using Single Nucleotide Polymorphisms (SNP) developed using the restriction-site associated DNA (RAD) sequencing technique with the restriction enzyme, PstI. A total of 6,647 SNPs were assigned to 22 linkage groups...

Optimizing a global alignment of protein interaction networks

Motivation: The global alignment of protein interaction networks is a widely studied problem. It is an important first step in understanding the relationship between the proteins in different species and identifying functional orthologs. Furthermore, it can provide useful insights into the species’ evolution. Results: We propose a novel algorithm, PISwap, for optimizing global...

The CDH1 -160C/A polymorphism is associated with breast cancer: evidence from a meta-analysis

Background Numerous epidemiological studies have evaluated the association between the CDH1 -160C/A polymorphism and the risk of breast cancers. However, these studies have yielded conflicting results. To derive a more precise estimation of this association, this meta-analysis was conducted. Methods A comprehensive search using the keywords “CDH1,” “E-Cadherin,” “polymorphism...

Origin and Expansion of the Yunnan Shoot Borer, Tomicus yunnanensis (Coleoptera: Scolytinae): A Mixture of Historical Natural Expansion and Contemporary Human-Mediated Relocation

The Yunnan shoot borer, Tomicus yunnanensis, is a recently-discovered, aggressive pest of the Yunnan pine stands in southwestern China. Despite many bionomics studies and massive controlling efforts, research on its population genetics is extremely limited. The present study, aimed at investigating the origin and dispersal of this important forestry pest, analyzed the population...

High expression of substance P and its receptor neurokinin-1 receptor in colorectal cancer is associated with tumor progression and prognosis

High expression of substance P and its receptor neurokinin-1 receptor in colorectal cancer is associated with tumor progression and prognosis Xiao-Yi Chen,1,* Guo-Qing Ru,2,* Ying-Yu Ma,1 Jun Xie,3

Analysis of exfoliated gastric carcinoma cells attached on surgical supplies

Analysis of exfoliated gastric carcinoma cells attached on surgical supplies Xiao-Fen Yu,1 Ying-Yu Ma,2 Xian-Qin Hu,1 Qin-Fang Zhang,1 Zai-Yuan Ye3 1Operating Theatre, Zhejiang Provincial People’s