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Electrophysiological characteristics of pressure overload-induced cardiac hypertrophy and its influence on ventricular arrhythmias

. Investigation: Weifeng Jiang, Yu Zhang. Resources: Xiaowei Chen, Mu Qin, Weifeng Jiang, Yu Zhang. Supervision: Xu Liu. Writing ± original draft: Xiaowei Chen, Mu Qin. Writing ± review & editing: Xiaowei Chen

Diet-derived microRNAs: unicorn or silver bullet?

that otherwise regulation-relevant levels could be reached. Chen-Yu Zhang responds The mobility of small RNA molecules (siRNAs and miRNAs) from one species to another is a newly discovered mechanism for ... experimental functional studies of exogenous miRNA and the most significant challenges to addressing them successfully? Chen-Yu Zhang answers There are two types of “exogenous miRNAs,” including absorbed

Modulation of platelet-derived microparticles to adhesion and motility of human rheumatoid arthritis fibroblast-like synoviocytes

National Nature Science Foundation of China (no. 81470070), http://www.nsfc.gov.cn/. The author who received the funding: Yu Zhang. The funders had no role in study design, data collection and analysis ... Contributions Conceptualization: Binzhou Yang, Weigan Shen. Data curation: Wenwen Wang. Formal analysis: Weigan Shen. Funding acquisition: Yu Zhang. Investigation: Wenwen Wang, Jiahuan Liu, Zhongshuang Ma

Effects of Cu addition on microstructure and mechanical properties of as-cast Mg-6Zn magnesium alloy

The application of Mg-Zn binary alloys is restricted due to their developed dendritic microstructure and poor mechanical properties. In this study, an alloying method was used to improve the mechanical properties of Mg-Zn alloy. The Mg-6Zn magnesium alloys microalloyed with varying Cu content (0, 0.8, 1.5, 2.0 and 2.5wt.%) were fabricated by permanent mould casting, and the effects ...

A small-molecule/cytokine combination enhances hematopoietic stem cell proliferation via inhibition of cell differentiation

Background Accumulated evidence supports the potent stimulating effects of multiple small molecules on the expansion of hematopoietic stem cells (HSCs) which are important for the therapy of various hematological disorders. Here, we report a novel, optimized formula, named the SC cocktail, which contains a combination of three such small molecules and four cytokines. Methods ...

Multi-phase simultaneous segmentation of tumor in lung 4D-CT data with context information

Lung 4D computed tomography (4D-CT) plays an important role in high-precision radiotherapy because it characterizes respiratory motion, which is crucial for accurate target definition. However, the manual segmentation of a lung tumor is a heavy workload for doctors because of the large number of lung 4D-CT data slices. Meanwhile, tumor segmentation is still a notoriously ...

High levels of IGF-1 predict difficult intubation of patients with acromegaly

tomography and magnetic resonance imaging examinations and preoperative overnight polysomnography. The modified Mallampati classification, mouth opening, Yu Zhang and Xiaopeng Guo have contributed equally to

Large-scale ex vivo generation of human neutrophils from cord blood CD34+ cells

Conventional high-dose chemotherapy frequently leads to severe neutropenia, during which patients experience a high risk of infection. Although support care with donor’s neutrophils is possible this choice is largely hampered by the limited availability of matched donors. To overcome this problem, we explored a large-scale ex vivo production of neutrophils from hematopoietic stem ...

Phosphatase and tensin homolog (PTEN) expression on oncologic outcome in renal cell carcinoma: A systematic review and meta-analysis

. Methodology: Liangyou Gu. Project administration: Yu Zhang. Resources: Xiangjun Lyu. Software: Luyao Chen. Supervision: Xu Zhang. 11 / 14 Validation: Xu Zhang. Visualization: Jianwen Chen. Writing

How genetic variation is affected by geographic environments and ploidy level in Erianthus arundinaceus?

Erianthus arundinaceus is not only a candidate plant for sugarcane breeding programs, but also a potential bioenergy grass. Genetic variation that is affected by geographic environments and ploidy level is very important for the utilization of Erianthus arundinaceus. In this study, effects of geographic environments and ploidy level on genetic variation were studied through ...

The toxic effects and possible mechanisms of Brusatol on mouse oocytes

Brusatol is a natural quassinoid that shows a potential therapeutic use in cancer models by the inhibition of Nuclear factor erythroid 2-related factor 2 (Nrf2) and is capable of inducing a variety of biological effects. The effects of Brusatol on oocyte meiosis has not been addressed. In this study, we investigated the impact of Brusatol treatment on mouse oocyte maturation and ...

DOT1L inhibitor improves early development of porcine somatic cell nuclear transfer embryos

Incomplete epigenetic reprogramming of the genome of donor cells causes poor early and full-term developmental efficiency of somatic cell nuclear transfer (SCNT) embryos. Previous research indicate that inhibition of the histone H3 K79 methyltransferase DOT1L, using a selective pharmacological inhibitor EPZ004777 (EPZ), significantly improved reprogramming efficiency during the ...

In situ synthesis of silver/chemically reduced graphene nanocomposite and its use for low temperature conductive paste

In this work, we succeeded in the synthesis of Ag/chemically reduced graphene (Ag/G) nanocomposite by a facile in situ one-pot solvothermal route. X-ray diffraction, X-ray photoelectron spectroscopy, Raman spectra and Fourier transform infrared spectroscopy results revealed the formation of Ag and the reduction of graphite oxide to graphene during the one-pot process. Scanning ...

Moderate injury in motor-sensory cortex causes behavioral deficits accompanied by electrophysiological changes in mice adulthood

Moderate traumatic brain injury (TBI) in children often happen when there’s a sudden blow to the frontal bone, end with long unconscious which can last for hours and progressive cognitive deficits. However, with regard to the influences of moderate TBI during children adulthood, injury-induced alterations of locomotive ability, long-term memory performance, and hippocampal ...

Characterization of a novel panel of plasma microRNAs that discriminates between Mycobacterium tuberculosis infection and healthy individuals

-Min Zhang, Chen-Yu Zhang, Hong Ling. Data curation: Hong-Wei Liang, Xin-Ling Pan, Yan-Hong Liu, Xiao-Yu He, Hong Ling. Formal analysis: Jin Fu, Chi-Hao Zhao, Xi Chen. Investigation: Jia-Yi Cui ... . Methodology: Jia-Yi Cui, Hong-Wei Liang, Xin-Ling Pan, Chi-Hao Zhao, Dong-Hai Li, Xi Project administration: Ke Zen, Feng-Min Zhang, Chen-Yu Zhang, Hong Ling. Resources: Xin-Ling Pan, Na Jiao, Yan-Hong Liu

Urinary Proteomics in Predicting Heart Transplantation Outcomes (uPROPHET)—Rationale and database description

: Qi-Fang Huang, Sander Trenson, Zhen-Yu Zhang, Lucas Van Aelst. Formal analysis: Qi-Fang Huang, Lutgarde Thijs, Jan A. Staessen. 13 / 17 Investigation: Qi-Fang Huang, Zhen-Yu Zhang, Wen-Yi Yang ... . Visualization: Qi-Fang Huang, Fang-Fei Wei. Writing ± original draft: Qi-Fang Huang, Jan A. Staessen. Writing ± review & editing: Qi-Fang Huang, Sander Trenson, Zhen-Yu Zhang, Wen-Yi Yang, Lucas Van Aelst

Metabolomic mechanisms of gypenoside against liver fibrosis in rats: An integrative analysis of proteomics and metabolomics data

Aims To investigate mechanisms and altered pathways of gypenoside against carbon tetrachloride (CCl4)-induced liver fibrosis based on integrative analysis of proteomics and metabolomics data. Methods CCl4-induced liver fibrosis rats were administrated gypenoside. The anti-fibrosis effects were evaluated by histomorphology and liver hydroxyproline (Hyp) content. Protein profiling ...

Discovery of microRNAs during early spermatogenesis in chicken

Guo for their help with sample preparation. We also thank Guobin Chang for his help with manuscript preparation. Author Contributions Conceptualization: G. Chen. Data curation: Yu Zhang. Formal

Seasonal and Inter-Annual Variations in Carbon Dioxide Exchange over an Alpine Grassland in the Eastern Qinghai-Tibetan Plateau

This work analyzed carbon dioxide exchange and its controlling factors over an alpine grassland on the eastern Qinghai-Tibetan Plateau. The main results show that air temperature and photosynthetically active radiation are two dominant factors controlling daily gross primary production. Soil temperature and soil water content are the main factors controlling ecosystem respiration. ...

In situ synthesis of silver/chemically reduced graphene nanocomposite and its use for low temperature conductive paste

In this work, we succeeded in the synthesis of Ag/chemically reduced graphene (Ag/G) nanocomposite by a facile in situ one-pot solvothermal route. X-ray diffraction, X-ray photoelectron spectroscopy, Raman spectra and Fourier transform infrared spectroscopy results revealed the formation of Ag and the reduction of graphite oxide to graphene during the one-pot process. Scanning ...