Advanced search    

Search: authors:"Yu Zhang"

480 papers found.
Use AND, OR, NOT, +word, -word, "long phrase", (parentheses) to fine-tune your search.

Oncogenic miR-19a and miR-19b co-regulate tumor suppressor MTUS1 to promote cell proliferation and migration in lung cancer

, Chen-Yu Zhang, Tao Wang, Chen wang, Junfeng Zhang, and Xi Chen declare that they have no competing interests. All procedures followed were in accordance with the ehhical standards of the responsible

In situ synthesis of silver/chemically reduced graphene nanocomposite and its use for low temperature conductive paste

In this work, we succeeded in the synthesis of Ag/chemically reduced graphene (Ag/G) nanocomposite by a facile in situ one-pot solvothermal route. X-ray diffraction, X-ray photoelectron spectroscopy, Raman spectra and Fourier transform infrared spectroscopy results revealed the formation of Ag and the reduction of graphite oxide to graphene during the one-pot process. Scanning ...

RNA-TVcurve: a Web server for RNA secondary structure comparison based on a multi-scale similarity of its triple vector curve representation

Background RNAs have been found to carry diverse functionalities in nature. Inferring the similarity between two given RNAs is a fundamental step to understand and interpret their functional relationship. The majority of functional RNAs show conserved secondary structures, rather than sequence conservation. Those algorithms relying on sequence-based features usually have ...

IL-17A Monoclonal Antibody Partly Reverses the Glucocorticoids Insensitivity in Mice Exposed to Ozonec

Exposure to ozone has been associated with airway inflammation and glucocorticoid insensitivity. This study aimed to observe the capacity of anti-murine interleukin-17A monoclonal antibody (IL-17mAb) to reverse ozone-induced glucocorticoid insensitivity and to detect its effects with glucocorticoids in protecting against airway inflammation. After C57/BL6 mice were exposed to ozone ...

An effective ex-vivo approach for inducing endothelial progenitor cells from umbilical cord blood CD34+ cells

Background Transplantation of endothelial progenitor cells (EPCs)/endothelial cells (ECs) has been used for the treatment of ischemic diseases and hemophilia A, due to their great capacity for producing factor VIII and for repairing vascular damage. We established an effective approach to stimulate the expansion and differentiation of EPCs for potential therapeutic applications. ...

Landau quantization of Dirac fermions in graphene and its multilayers

When electrons are confined in a two-dimensional (2D) system, typical quantum–mechanical phenomena such as Landau quantization can be detected. Graphene systems, including the single atomic layer and few-layer stacked crystals, are ideal 2D materials for studying a variety of quantum–mechanical problems. In this article, we review the experimental progress in the unusual Landau ...

The Effect of Superparamagnetic Iron Oxide Nanoparticle Surface Charge on Antigen Cross-Presentation

Yu Zhang 6 Guangjie Yu 0 7 Walter J. Urba 5 Qingang Hu 2 Hongming Hu 0 0 Laboratory of Cancer Immunobiology, Robert W. Franz Cancer Research Center, Earle A. Chiles Research Institute, Providence

Ex-vivo expansion of nonhuman primate CD34+ cells by stem cell factor Sall4B

Background Hematopoietic CD34+ stem cells are widely used in the clinical therapy of complicated blood diseases. Stem cell factor Sall4B is a zinc finger transcription factor that plays a vital role in hematopoietic stem cell expansion. The purpose of our current study is to further evaluate how Sall4B might affect the expansion of CD34+ cells derived from nonhuman primates. ...

Acute stress enhances the glutamatergic transmission onto basoamygdala neurons embedded in distinct microcircuits

Amygdala activation is known to be critical for the processing of stressful events in brain. Recent studies have shown that the projection neurons (PNs) in amygdala, although architecturally intermingled, are integrated into distinct microcircuits and thus play divergent roles in amygdala-related behaviors. It remains unknown how stress regulates the individual amygdala PNs ...

In vivo whole-cell recording with high success rate in anaesthetized and awake mammalian brains

As a critical technique for dissection of synaptic and cellular mechanisms, whole-cell patch-clamp recording has become feasible for in vivo preparations including both anaesthetized and awake mammalian brains. However, compared with in vitro whole-cell recording, in vivo whole-cell recording often suffers from low success rates and high access resistance, preventing its wide ...

B cell regulation of the anti-tumor response and role in carcinogenesis

The balance between immune effector cells such as T cells and natural killer cells, and immunosuppressive Treg cells, dendritic, myeloid and monocytic sub-populations in the tumor microenvironment acts to calibrate the immune response to malignant cells. Accumulating evidence is pointing to a role for B cells in modulating the immune response to both solid tumors and hematologic ...

The Diversification of Plant NBS-LRR Defense Genes Directs the Evolution of MicroRNAs That Target Them

High expression of plant nucleotide binding site leucine-rich repeat (NBS-LRR) defense genes is often lethal to plant cells, a phenotype perhaps associated with fitness costs. Plants implement several mechanisms to control the transcript level of NBS-LRR defense genes. As negative transcriptional regulators, diverse miRNAs target NBS-LRRs in eudicots and gymnosperms. To understand ...

Ethnobotanical study of traditional edible plants used by the Naxi people during droughts

Background Since 2009, millions of people have been forced to live under food shortage by the continuous drought in Southwestern China. The market was the primary source of aid grains, and fears that the market will be unable to provide sufficient food make safeguarding food security in the face of climate change crucial. Traditional adaptive strategies of pre-market indigenous ...

A novel pyruvate kinase and its application in lactic acid production under oxygen deprivation in Corynebacterium glutamicum

Background Pyruvate kinase (Pyk) catalyzes the generation of pyruvate and ATP in glycolysis and functions as a key switch in the regulation of carbon flux distribution. Both the substrates and products of Pyk are involved in the tricarboxylic acid cycle, anaplerosis and energy anabolism, which places Pyk at a primary metabolic intersection. Pyks are highly conserved in most ...

Stability of numerical method for semi-linear stochastic pantograph differential equations

As a particular expression of stochastic delay differential equations, stochastic pantograph differential equations have been widely used in nonlinear dynamics, quantum mechanics, and electrodynamics. In this paper, we mainly study the stability of analytical solutions and numerical solutions of semi-linear stochastic pantograph differential equations. Some suitable conditions for ...

Jointly characterizing epigenetic dynamics across multiple human cell types

Advanced sequencing technologies have generated a plethora of data for many chromatin marks in multiple tissues and cell types, yet there is lack of a generalized tool for optimal utility of those data. A major challenge is to quantitatively model the epigenetic dynamics across both the genome and many cell types for understanding their impacts on differential gene regulation and ...

Alantolactone selectively ablates acute myeloid leukemia stem and progenitor cells

Background The poor outcomes for patients diagnosed with acute myeloid leukemia (AML) are largely attributed to leukemia stem cells (LSCs) which are difficult to eliminate with conventional therapy and responsible for relapse. Thus, new therapeutic strategies which could selectively target LSCs in clinical leukemia treatment and avoid drug resistance are urgently needed. However, ...

Coderivatives of gap function for Minty vector variational inequality

The purpose of this paper is to investigate coderivatives of the gap function involving the Minty vector variational inequality. First, we discuss the regular coderivative, the normal coderivative, and the mixed coderivative of a class of set-valued maps. Then, by using the relationships between the coderivatives of a set-valued map and its efficient points set-valued map, we ...

Comparative RNA-Seq profiling of berry development between table grape ‘Kyoho’ and its early-ripening mutant ’Fengzao’

Background Early ripening is an important desirable attribute for fruit crops. ‘Kyoho’ is a popular table grape cultivar in many Asian countries. ‘Fengzao’ is a bud mutant of ‘Kyoho’ and ripens nearly 30 days earlier than ‘Kyoho’. To identify genes controlling early fruit development and ripening in ‘Fengzao’, RNA-Seq profiles of the two cultivars were compared at 8 different berry ...