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Integrated analysis of transcriptomic and metabolomic data reveals critical metabolic pathways involved in rotenoid biosynthesis in the medicinal plant Mirabilis himalaica

Mirabilis himalaica (Edgew.) Heimerl is among the most important genuine medicinal plants in Tibet. However, the biosynthesis mechanisms of the active compounds in this species are unclear, severely limiting its application. To clarify the molecular biosynthesis mechanism of the key representative active compounds, specifically rotenoid, which is of special medicinal value for M...

Prognostic analysis for Chinese patients with stage I ovarian endometrioid carcinoma

This study aimed to identify the clinical and pathological characteristics and the possible prognostic factors for Chinese patients with early-stage ovarian endometrioid carcinoma. The present study reviewed the medical records of patients who received initial treatment and a postoperative pathological diagnosis of ovarian endometrioid carcinoma at our center. In all, 78 patients...

Study on garbage disposal mode with low energy consumption for villages and towns in cold region

Through field research of typical villages and towns in China's northern cold region, this paper research energy consumption and resource recovery in the process of village and town garbage collection and disposal and organizes current situation and problems of village and town garbage collection and disposal. At present, village and town garbage collection and disposal means and...

Recent Advances on Neural Headline Generation

. degree in computer science from the Department of Computer Science and Technology, Tsinghua University, Beijing, in 2013 . His research interests are user representation and social computation. Yu Zhao is

Regulating Charge and Exciton Distribution in High-Performance Hybrid White Organic Light-Emitting Diodes with n-Type Interlayer Switch

The interlayer (IL) plays a vital role in hybrid white organic light-emitting diodes (WOLEDs); however, only a negligible amount of attention has been given to n-type ILs. Herein, the n-type IL, for the first time, has been demonstrated to achieve a high efficiency, high color rendering index (CRI), and low voltage trade-off. The device exhibits a maximum total efficiency of 41.5...

The chimeric Japanese encephalitis/Dengue 2 virus protects mice from challenge by both dengue virus and JEV virulent virus

funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Jian Yang, Huiqiang Yang, Zhushi Li, Hua Lin, Yu Zhao, Wei Wang, Shuai Tan, Xianwu

A method based on iterative morphological filtering and multiple scattering for detecting layer boundaries and extinction coefficients with LIDAR

Layer boundaries detection with LIDAR is of great significance for the meteorological and environmental research. Apart from the background noise, multiple scattering can also seriously affect the detection results in LIDAR signal processing. To alleviate these issues, a novel approach was proposed based upon morphological filtering and multiple scattering correction with...

Aggregation of AcMNPV LEF-10 and Its Impact on Viral Late Gene Expression

The Autographa californica multiple nucleopolyhedrovirus (AcMNPV) late expression factor gene lef-10 has been identified to be required for viral late gene expression by transient expression assay. Our previous work has shown that the gene product LEF-10 can form very stable high-molecular-weight complexes, but the structure and function of the protein remain unknown. In this...

A novel BCR-ABL1 fusion gene identified by next-generation sequencing in chronic myeloid leukemia

Background BCR-ABL1 fusion proteins contain constitutively active tyrosine kinases that are potential candidates for targeted therapy with tyrosine kinase inhibitors such as imatinib in chronic myeloid leukemia (CML). However, uncharacterized BCR-ABL1 fusion genes can be missed by quantitative RT-PCR (qRT-PCR)-based routine screening methods, causing adverse effect on drug...

Inhibition of Snail Family Transcriptional Repressor 2 (SNAI2) Enhances Multidrug Resistance of Hepatocellular Carcinoma Cells

China accounts for almost half of the total number of liver cancer cases and deaths worldwide, and hepatocellular carcinoma (HCC) is the most primary liver cancer. Snail family transcriptional repressor 2 (SNAI2) is known as an epithelial to mesenchymal transition-inducing transcription factor that drives neoplastic epithelial cells into mesenchymal phenotype. However, the roles...

Posterior Corneal Elevation after Small Incision Lenticule Extraction for Moderate and High Myopia

Purpose To investigate the changes of posterior corneal elevation after small incision lenticule extraction (SMILE) for moderate and high myopia. Methods In this prospective study, fifty consecutive eyes of thirty patients (10 male, 20 female) who underwent SMILE for myopia and myopic astigmatism were included. Eyes were divided in two groups based on the preoperative spherical...

Pleural Effusion in Spinal Deformity Correction Surgery- A Report of 28 Cases in a Single Center

Objectives To analyze the occurrence, risk factors, treatment and prognosis of postoperative pleural effusion after spinal deformity correction surgery. Methods The clinical and imaging data of 3325 patients undergoing spinal deformity correction were collected from the database of our hospital. We analyzed the therapeutic process of the 28 patients who had postoperative pleural...

Rice black streaked dwarf virus P7-2 forms a SCF complex through binding to Oryza sativa SKP1-like proteins, and interacts with GID2 involved in the gibberellin pathway

As a core subunit of the SCF complex that promotes protein degradation through the 26S proteasome, S-phase kinase-associated protein 1 (SKP1) plays important roles in multiple cellular processes in eukaryotes, including gibberellin (GA), jasmonate, ethylene, auxin and light responses. P7-2 encoded by Rice black streaked dwarf virus (RBSDV), a devastating viral pathogen that...

Norlichexanthone Reduces Virulence Gene Expression and Biofilm Formation in Staphylococcus aureus

Staphylococcus aureus is a serious human pathogen and antibiotic resistant, community-associated strains, such as the methicillin resistant S. aureus (MRSA) strain USA300, continue to spread. To avoid resistance, anti-virulence therapy has been proposed where toxicity is targeted rather than viability. Previously we have shown that norlichexanthone, a small non-reduced tricyclic...

Tenuigenin promotes the osteogenic differentiation of bone mesenchymal stem cells in vitro and in vivo

Osteoporosis, which is a systemic skeletal disease characterized by low bone mineral density and microarchitectural deterioration of bone quality, is a global and increasing public health problem. Recent studies have suggested that Tenuigenin (TEN), a class of native compounds with numerous biological activities such as anti-resorptive properties, exerts protective effects...

Expression of Semaphorin 4A and its potential role in rheumatoid arthritis

Introduction Semaphorin 4A (Sema4A) plays critical roles in many physiological and pathological processes including neuronal development, angiogenesis, immune response regulation, autoimmunity, and infectious diseases. The present study aimed to investigate its expression and biological activity in rheumatoid arthritis (RA). Methods RNA and protein were isolated from synovial...

The Impact of spgM, rpfF, rmlA Gene Distribution on Biofilm Formation in Stenotrophomonas maltophilia

Formation in Stenotrophomonas maltophilia Chao Zhuo 0 Qian-yu Zhao 0 Shu-nian Xiao 0 Dipshikha Chakravortty, Indian Institute of Science, India 0 State Key Laboratory of Respiratory Diseases, the first

HAFNI-enabled largescale platform for neuroimaging informatics (HELPNI)

currently also a joint Ph.D. student in The University of Georgia. His research interest focuses on human brain mapping and fMRI analysis. He has published over 45 peer-reviewed papers in this area. Yu Zhao

MzPIP2;1: An Aquaporin Involved in Radial Water Movement in Both Water Uptake and Transportation, Altered the Drought and Salt Tolerance of Transgenic Arabidopsis

Background Plants are unavoidably subjected to various abiotic stressors, including high salinity, drought and low temperature, which results in water deficit and even death. Water uptake and transportation play a critical role in response to these stresses. Many aquaporin proteins, localized at different tissues, function in various transmembrane water movements. We targeted at...

LSY-2 is essential for maintaining the germ-soma distinction in C. elegans

; ASER, ASE right; DRM, LIN-35/RB-containing core complex; Muv, multi-vulva COMPLIANCE WITH ETHICS GUIDELINES Long Lin, Yuping Li, Libo Yan, Gangming Zhang, Yu Zhao, and Hong Zhang declare that they have