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Search: authors:"Yu-Han Cao"

4 papers found.
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Are Urinary Tubular Injury Markers Useful in Chronic Kidney Disease? A Systematic Review and Meta Analysis

Background Adverse outcome of chronic kidney disease, such as end stage renal disease, is a significant burden on personal health and healthcare costs. Urinary tubular injury markers, such as NGAL, KIM-1 and NAG, could provide useful prognostic value for the early identification of high-risk patients. However, discrepancies between recent large prospective studies have resulted in ...

A Pilot Trial Assessing Urinary Gene Expression Profiling with an mRNA Array for Diabetic Nephropathy

Background The initiation and progression of diabetic nephropathy (DN) is complex. Quantification of mRNA expression in urinary sediment has emerged as a novel strategy for studying renal diseases. Considering the numerous molecules involved in DN development, a high-throughput platform with parallel detection of multiple mRNAs is needed. In this study, we constructed a ...

Biomarkers

Introduction and Aims: The stratification of chronic kidney disease (CKD) patients, to identify those at high risk of poor outcomes, requires tests that individually assess kidney function, kidney injury and systemic inflammation. Due to the limitations of the individual markers, here we evaluate a marker of immune status and kidney function, combined polyclonal serum free light ...

Lab methods / biomarkers

Introduction and Aims:Patients with Chronic Kidney Disease (CKD) and/or Diabetes are at a high risk for cardiovascular (CV) disease. Improved outcomes require a better understanding of specific risk factors that distinctly modulate the incidence of atheromatous disease. Herein. we compared the distinct and combined impact of CKD and of diabetes (DM) on the development of ...