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Association between serum aluminum levels and cardiothoracic ratio in patients on chronic hemodialysis

the study. (XLSX) Acknowledgments We thank our patients for contributing the dataset to this study. Author Contributions Conceptualization: Yu-Wei Fang. Data curation: Tzu-Lin Wang, Ming-Hsien Tsai ... . Formal analysis: Ming-Hsien Tsai. Investigation: Ming-Hsien Tsai. Methodology: Jyh-Gang Leu, Ming-Hsien Tsai. Supervision: Ming-Hsien Tsai. Validation: Tzu-Lin Wang, Yu-Wei Fang, Ming-Hsien Tsai

Tinzaparin Provides Lower Lipid Profiles in Maintenance Hemodialysis Patients: A Cross-Sectional Observational Study

As a low-molecular-weight heparin, tinzaparin has effectively been used as an anticoagulant during hemodialysis sessions. However, the impact of different heparin types on dyslipidemia is still controversial. In our study, 434 chronic hemodialysis patients were evaluated. The mean age was 65 ± 13. Forty-eight patients (11%) and 386 patients (89%) were in the tinzaparin and...

Chronic Metabolic Acidosis Activates Renal Tubular Sodium Chloride Cotransporter through Angiotension II-dependent WNK4-SPAK Phosphorylation Pathway

AuthorsSearch for Yu-Wei Fang in:Nature Research journals • PubMed • Google ScholarSearch for Sung-Sen Yang in:Nature Research journals • PubMed • Google ScholarSearch for Chih-Jen Cheng in:Nature Research

SPAK Deficiency Corrects Pseudohypoaldosteronism II Caused by WNK4 Mutation

Stimulation of the OSR1 (Oxidative stress-responsive kinase-1)/SPAK [STE20 (sterile 20)/SPS1-related proline/alanine-rich kinase]-NCC (Na+-Cl− cotransporter) signaling cascade plays an important role in the WNK [With-No-Lysine (K)] kinase 4 D561A knock-in mouse model of pseudohypoaldosteronism type II (PHA II) characterized by salt-sensitive hypertension and hyperkalemia. The aim...