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282 papers found.
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Nitric oxide attenuates overexpression of Giα proteins in vascular smooth muscle cells from SHR: Role of ROS and ROS-mediated signaling

Vascular smooth muscle cells (VSMC) from spontaneously hypertensive rats (SHR) exhibit decreased levels of nitric oxide (NO) that may be responsible for the overexpression of Giα proteins that has been shown as a contributing factor for the pathogenesis of hypertension in SHR. The present study was undertaken to investigate if increasing the intracellular levels of NO by NO donor ...

mTOR has a developmental stage-specific role in mitochondrial fitness independent of conventional mTORC1 and mTORC2 and the kinase activity

curation: Khalid W. Kalim, Shuangmin Zhang, Xiaoyi Chen, Yuan Li, Jun-Qi Yang. Formal analysis: Khalid W. Kalim, Shuangmin Zhang, Xiaoyi Chen, Yi Zheng, Fukun Guo. Funding acquisition: Fukun Guo

REM sleep deprivation induces endothelial dysfunction and hypertension in middle-aged rats: Roles of the eNOS/NO/cGMP pathway and supplementation with L-arginine

Contributions Conceptualization: Jian-Pu Zheng. Data curation: Jiaye Jiang, Yan Ke. Formal analysis: Jiaye Jiang, Zhongyuan Gan, Yuan Li, Wenqi Zhao, Hanqing Li. Funding acquisition: Jian-Pu Zheng, Yan Ke ... . Investigation: Jiaye Jiang, Zhongyuan Gan, Yuan Li, Wenqi Zhao, Hanqing Li. Methodology: Jiaye Jiang. Project administration: Jian-Pu Zheng, Yan Ke. Supervision: Jian-Pu Zheng, Yan Ke. Writing ± original

Contrasting patterns of nucleotide polymorphism suggest different selective regimes within different parts of the PgiC1 gene in Festuca ovina L.

Background Phosphoglucose isomerase (PGI, EC 5.3.1.9) is an essential metabolic enzyme in all eukaryotes. An earlier study of the PgiC1 gene, which encodes cytosolic PGI in the grass Festuca ovina L., revealed a marked difference in the levels of nucleotide polymorphism between the 5’ and 3’ portions of the gene. Methods In the present study, we characterized the sequence ...

Evolving use of social media among Chinese urologists: Opportunity or challenge?

practice. 9 / 11 Supporting information S1 Fig. The questionnaire. (PDF) Author Contributions Conceptualization: Xingbo Long, Long Wang. Data curation: Zhenyu Ou, Zhenzhen Cao, Yuan Li, Minfeng Chen

CCL20 secreted from IgA1-stimulated human mesangial cells recruits inflammatory Th17 cells in IgA nephropathy

IgA nephropathy (IgAN) is the most common primary glomerulonephritis characterized by human mesangial cells (HMC) proliferation and extracellular matrix expansion associated with immune deposits consisting of galactose-deficient IgA1. However, how IgA1 contributes to IgAN has yet to be completely elucidated. In this study, the expression profile of chemokines was more altered in ...

The 3-D Structural Basis for the Pgi Genotypic Differences in the Performance of the Butterfly Melitaea cinxia at Different Temperatures

Although genotype-by-environment interaction has long been used to unveil the genetic variation that affects Darwinian fitness, the mechanisms underlying the interaction usually remain unknown. Genetic variation at the dimeric glycolytic enzyme phosphoglucoisomerase (Pgi) has been observed to interact with temperature to explain the variation in the individual performance of the ...

Oils extracted from Eupatorium adenophorum leaves show potential to control Phythium myriotylum in commercially-grown ginger

Oils extracted from the leaves of Eupatorium adenophorum were tested in vitro and in vivo against the soilborne pathogen Pythium myriotylum which causes soft rot, a devastating disease of commercial ginger production in China. Twelve compounds accounting for 99.15% of the total oil composition were identified by GC-MS. The major components were 10Hβ-9-oxo-agerophorone (37.03%), ...

Rheology of rock salt for salt tectonics modeling

Numerical modeling of salt tectonics is a rapidly evolving field; however, the constitutive equations to model long-term rock salt rheology in nature still remain controversial. Firstly, we built a database about the strain rate versus the differential stress through collecting the data from salt creep experiments at a range of temperatures (20–200 °C) in laboratories. The aim is ...

Wogonin as a targeted therapeutic agent for EBV (+) lymphoma cells involved in LMP1/NF-κB/miR-155/PU.1 pathway

Background Wogonin is an encouraging choice for clinical use owing to its potent anti-tumor and anti-inflammatory effects with the high safety profile. However, wogonin for targeted therapy of lymphoma was not well addressed. In this study, we focused on its anticancer effect alongside with the underlying mechanisms for targeted therapy in EBV-positive lymphoma. This will ...

CLASP2 is involved in the EMT and early progression after transurethral resection of the bladder tumor

Background Cytoplasmic linker-associated protein 2 (CLASP2) belongs to a family of microtubule plus-end tracking proteins that localizes to the distal ends of microtubules and regulate microtubule dynamics. We speculated that it might be involved in the epithelial-mesenchymal transition (EMT) and progression of bladder cancer (BC). Methods Western blotting and RT-PCR were used to ...

Improved Data Preprocessing Algorithm for Time-Domain Induced Polarization Method with Digital Notch Filter

Time-domain induced polarization (TDIP) measurement is seriously affected by power line interference and other field noise. Moreover, existing TDIP instruments generally output only the apparent chargeability, without providing complete secondary field information. To increase the robustness of TDIP method against interference and obtain more detailed secondary field information, ...

Astaxanthin attenuates total body irradiation-induced hematopoietic system injury in mice via inhibition of oxidative stress and apoptosis

Background The hematopoietic system is especially sensitive to total body irradiation (TBI), and myelosuppression is one of the major effects of TBI. Astaxanthin (ATX) is a powerful natural anti-oxidant with low toxicity. In this study, the effect of ATX on hematopoietic system injury after TBI was investigated. Methods Flow cytometry was used to detect the proportion of ...

Gold nanoparticle integrated with nanostructured carbon and quantum dots: synthesis and optical properties

Multilayer graphene shell encapsulated gold nanoparticle—quantum dot hybrids were derived by combining wet-chemical, thermal, and covalent chemistry approaches. Uniformly patterned gold nanoparticles on a silicon substrate were obtained via gold film deposition in an electroless method followed by a thermal dewetting process. The resulting gold nanoparticles were further surface ...

Screening gestational diabetes mellitus: The role of maternal age

Objective Using a specific cutoff of fasting plasma glucose (FPG) to screen gestational diabetes mellitus (GDM) can reduce the use of oral glucose tolerance tests (OGTT). Since the prevalence of GDM increases with age, this screening method may not be appropriate in healthcare systems where women become pregnant at older ages. Therefore, we aimed to develop a screening algorithm ...

A statistical approach for identifying differential distributions in single-cell RNA-seq experiments

The ability to quantify cellular heterogeneity is a major advantage of single-cell technologies. However, statistical methods often treat cellular heterogeneity as a nuisance. We present a novel method to characterize differences in expression in the presence of distinct expression states within and among biological conditions. We demonstrate that this framework can detect ...

Capecitabine in Combination with Standard (Neo)Adjuvant Regimens in Early Breast Cancer: Survival Outcome from a Meta-Analysis of Randomized Controlled Trials

Sui-Ling Lin 0 2 Xu-Yuan Li 2 0 Department of Prevention and Health Care, Cancer Hospital of Shantou University Medical College , Shantou, Guangdong , China , 4 Department of Medical Oncology, Shantou

Copy number variants of ABCF1, IL17REL, and FCGR3A are associated with the risk of gout

., S.J., Y.W., Y.C., and Y.L. contributed reagents/materials/analysis tools. J.W., Z.D., H.Z., F.Z., and L.J. wrote the paper. Zheng Dong, Yuan Li, Jingru Zhou, Shuai Jiang, Yi Wang, Yulin Chen, Dongbao ... give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Zheng Dong and Yuan Li have contributed equally

Epidermal Growth Factor Receptor and Ki-67 as Predictive Biomarkers Identify Patients Who Will Be More Sensitive to Intravesical Instillations for the Prevention of Bladder Cancer Recurrence after Radical Nephroureterectomy

Background To date, prophylactic intravesical chemotherapy after radical nephroureterectomy is one of the few available treatments that effectively prevent secondary bladder cancer. However, treating all patients with prophylactic intravesical chemotherapy is excessive for patients who are at a low risk or insensitive to the treatment. Thus, to guide individualized clinical ...

Rosuvastatin Attenuates CD40L-Induced Downregulation of Extracellular Matrix Production in Human Aortic Smooth Muscle Cells via TRAF6-JNK-NF-κB Pathway

CD40L and statins exhibit pro-inflammatory and anti-inflammatory effects, respectively. They are both pleiotropic and can regulate extracellular matrix (ECM) degeneration in an atherosclerotic plaque. Statins can decrease both the CD40 expression and the resulting inflammation. However, the effects of CD40L and stains on atherosclerotic plaque ECM production and the underlying ...