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199 papers found.
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The relation between health insurance and management of hypertension in Shanghai, China: a cross-sectional study

Background We aimed to investigate the management of hypertension in Shanghai, China and to examine whether there was any difference of hypertension management among people enrolled in different health insurances. Methods In this cross-sectional study, a total of 31,531 residents were selected in Shanghai, using a randomized, stratified, multi-stage sampling method, and were asked ...

Effects of Rho1, a small GTPase on the production of recombinant glycoproteins in Saccharomyces cerevisiae

Background To humanize yeast N-glycosylation pathways, genes involved in yeast specific hyper-mannosylation must be disrupted followed by the introduction of genes catalyzing the synthesis, transport, and addition of human sugars. However, deletion of these genes, for instance, OCH1, which initiates hyper-mannosylation, could cause severe defects in cell growth, morphogenesis and ...

Duck Hepatitis B Virus cccDNA Amplification Efficiency in Natural Infection Is Regulated by Virus Secretion Efficiency

Previous mutation based studies showed that ablating synthesis of viral envelope proteins led to elevated hepadnaviral covalently closed circular DNA (cccDNA) amplification, but it remains unknown how cccDNA amplification is regulated in natural hepadnaviral infection because of a lack of research system. In this study we report a simple procedure to prepare two identical duck ...

Development of Novel Biocomposite Scaffold of Chitosan-Gelatin/Nanohydroxyapatite for Potential Bone Tissue Engineering Applications

In this study, a three-dimensional chitosan-gelatin/nanohydroxyapatite (ChG/nHaP) scaffold was successfully fabricated and characterized in terms of swelling, degradation, cell proliferation, cell attachment, and mineralization characterizations. The ChG/nHaP scaffold was fabricated with a mean pore size of 100–180 μm. Our results showed that the physicochemical and biological ...

Whole-genome regulation analysis of histone H3 lysin 27 trimethylation in subclinical mastitis cows infected by Staphylococcus aureus

Background S. aureus is one of the major etiological agents causing bovine subclinical mastitis. The regulatory effects of H3K27me3 on gene expression in subclinical S. aureus mastitis cows are unknown. This study aimed to profile genome-wide transcriptional changes regulated by H3K27me3 in bovine lymphocytes applied in subclinical S. aureus mastitis cows and healthy controls. ...

N-acetylcysteine attenuates myocardial dysfunction and postischemic injury by restoring caveolin-3/eNOS signaling in diabetic rats

Background Patients with diabetes are prone to develop cardiac hypertrophy and more susceptible to myocardial ischemia–reperfusion (I/R) injury, which are concomitant with hyperglycemia-induced oxidative stress and impaired endothelial nitric oxide (NO) synthase (eNOS)/NO signaling. Caveolae are critical in the transduction of eNOS/NO signaling in cardiovascular system. Caveolin ...

The formation of glass: a quantitative perspective

In constant use since ancient times, glass remains a highly valued material that is ubiquitous in daily life. Today, glass has become an indispensable and essential component in such fields as photonics, optical communications, photovoltaic cells, household appliances, vehicles, and building materials. However, one of major stumbling blocks for its optimal use is the low ...

Association between the Interaction of Key Genes Involved in Effector T-Cell Pathways and Susceptibility to Developallergic Rhinitis: A Population-Based Case-Control Association Study

Background Evidence suggests that interaction between key genes mediating signaling and transcriptional networks involving effector T-cell responses may influence an individual’s susceptibility to develop allergic rhinitis(AR). Objective The aim of this study was todetermine whether specific interactions between key genes involved in effector T-cell pathways are associated with an ...

Young Cervical Cancer Patients May Be More Responsive than Older Patients to Neoadjuvant Chemotherapy Followed by Radical Surgery

Objective To evaluate the effects of age and the clinical response to neoadjuvant chemotherapy (NACT) in patients with cervical cancer who received neoadjuvant chemotherapy followed by radical surgery. Methods A total of 1,014 patients with advanced cervical cancer who received NACT followed by radical surgery were retrospectively selected. Patients were divided into young (aged ...

Treatment of idiopathic pulmonary fibrosis: a network meta-analysis

Background Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease associated with high morbidity and mortality. Effective treatments for IPF are limited. Several recent studies have investigated novel therapeutic agents for IPF, but very few have addressed their comparative benefits and harms. Methods We performed a Bayesian network meta-analysis (NMA) to assess the ...

Massive 2-form field and holographic ferromagnetic phase transition

In this paper we investigate in some detail the holographic ferromagnetic phase transition in an AdS4 black brane background by introducing a massive 2-form field coupled to the Maxwell field strength in the bulk. In two probe limits, one is to neglect the back reaction of the 2-form field to the background geometry and to the Maxwell field, and the other to neglect the back ...

Missed Opportunities to Address Cardiovascular Disease Risk Factors amongst Adults Attending an Urban HIV Clinic in South Africa

We assessed cardiovascular disease (CVD) risk factor prevalence and risk stratification amongst adults on antiretroviral therapy in South Africa. Of the 175 patients screened, 37.8% had high blood pressure (HBP), 15.4% were current smokers, 10.4% had elevated cholesterol, and 4.1% had diabetes, but very few (3.6%) had a 10-year CVD risk >10%. One-third of those with HBP, 40% of ...

Erratum to: Lentiviral-Mediated Netrin-1 Overexpression Improves Motor and Sensory Functions in SCT Rats Associated with SYP and GAP-43 Expressions

authors in the online published article have corrections. The authors do hereby correct these as Xue primary corresponding author and to add another affiliation for Yuan Zhang. These are presented below

Role of high-mobility group box 1 in methamphetamine-induced activation and migration of astrocytes

Background Mounting evidence has indicated that high-mobility group box 1 (HMGB1) is involved in cell activation and migration. Our previous study demonstrated that methamphetamine mediates activation of astrocytes via sigma-1 receptor (σ-1R). However, the elements downstream of σ-1R in this process remain poorly understood. Thus, we examined the molecular mechanisms involved in ...

Transcriptomic analyses reveal species-specific light-induced anthocyanin biosynthesis in chrysanthemum

Background The flower colour of agricultural products is very important for their commercial value, which is mainly attributed to the accumulation of anthocyanins. Light is one of the key environmental factors that affect the anthocyanin biosynthesis. However, the deep molecular mechanism remains elusive, and many problems regarding the phenotypic change and the corresponding gene ...

Energy-efficient design of two-tier femtocell networks

With the exponential increase in mobile internet traffic, future cellular networks face great challenges to satisfy the demand of network capacity. At the same time, high data rate transmission and rapid increasing number of users also seriously burden the power consumption and the cost of cellular networks. Base station (BS) is the main part of power consumption, so reducing ...

Reducing Antibiotic Use for Young Children with Intussusception following Successful Air Enema Reduction

. Supporting Information S1 Table. Database of antibiotic use for young children with intussusception. (XLS) Author Contributions Conceived and designed the experiments: Yuan Zhang WZ HYJ. Performed the ... experiments: Yinghui Zhang QL. Analyzed the data: Yuan Zhang WZ. Contributed reagents/materials/analysis tools: Yinghui Zhang HDL CFS. Wrote the paper: Yuan Zhang WZ. Revised manuscript: WMY XDC. Final approval