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Pain aversion and anxiety-like behavior occur at different times during the course of chronic inflammatory pain in rats

Pain aversion and anxiety-like behavior occur at different times during the course of chronic inflammatory pain in rats Yuanyuan Wu,1 Xinmiao Yao,2 Yongliang Jiang,1 Xiaofen He,1 Xiaomei Shao,1

Up-regulation of lncRNA CASC9 promotes esophageal squamous cell carcinoma growth by negatively regulating PDCD4 expression through EZH2

Abnormal expression of numerous long non-coding RNAs (lncRNAs) has been reported in esophageal squamous cell carcinoma (ESCC) recently, but the great majority of their roles and mechanisms remain largely unclear. We aim to identify the critical ESCC-associated lncRNAs and elucidate the functions and mechanisms in detail. Microarrays were used to analyze the differentially...

EXPLORATION AND EXPLOITATION IN NEW VENTURES: COMBINING INTRA- AND INTER-ORGANIZATIONAL LEARNING FOR CAPABILITY DEVELOPMENT (SUMMARY)

Yuanyuan Wu, University of Windsor, Canada Paola Perez-Aleman, McGill University, Canada Principal Topic This study investigates how technology ventures develop capabilities through the lens of explorative

Genome-wide piggyBac transposon mediated screening reveals genes related to reprogramming

Scientists of State Key Laboratory of Agrobiotechnology 2015SKLAB6-15. Xi Zhang, Xinglin Wei, Yuanyuan Wu, Yuzhe Wang, Cheng Tan, Xiaoxiang Hu, Ning Li, Mario R. Capecchi and Sen Wu declare that they have no ... Li1, Mario R. Capecchi2, Sen Wu1& Xi Zhang, Xinglin Wei, and Yuanyuan Wu have contributed equally to this work. Electronic supplementary material The online version of this article (doi:10.1007/s13238

Effects of Tomato Root Exudates on Meloidogyne incognita

Plant root exudates affect root-knot nematodes egg hatch. Chemicals in root exudates can attract nematodes to the roots or result in repellence, motility inhibition or even death. However, until recently little was known about the relationship between tomato root exudates chemicals and root-knot nematodes. In this study, root exudates were extracted from three tomato rootstocks...

Promoter Hypomethylation of Maspin Inhibits Migration and Invasion of Extravillous Trophoblast Cells during Placentation

Objective Extravillous trophoblast (EVT) cells invade the endometrium and the maternal spiral arterioles during the first trimester. Mammary Serine Protease Inhibitor (Maspin, SERPINB5) plays a putative role in regulating the invasive activity of cytotrophoblasts. The maspin gene is silenced in various cancers by an epigenetic mechanism that involves aberrant cytosine methylation...

Up-regulation of long noncoding RNA MALAT1 contributes to proliferation and metastasis in esophageal squamous cell carcinoma

Background Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) has been demonstrated to be an important player in various human malignancies; it is thought to promote tumor growth by cell cycle regulating. However, the roles of MALAT1 in esophageal squamous cell carcinoma(ESCC), and the mechanisms involved in cell cycle regulation remain poorly understood. Moreover...

Fabrication of Large-area 3-D Ordered Silver-coated Colloidal Crystals and Macroporous Silver Films Using Polystyrene Templates

The highly ordered silver-coated colloidal crystals arrays and macroporous silver films were derived through an electrostatics-induced adsorption effect using polystyrene (PS) as templates. Carboxyl-modified PS microspheres were prepared by emulsifier-free emulsion polymerization using methacrylic acid (MAA) as the functional monomer. PS microspheres were self-assembled into...

Theoretical and Experimental Studies of N,N-Dimethyl-N′-Picryl-4,4′-Stilbenediamine

N,N-dimethyl-N′-picryl-4,4′-stilbenediamine (DMPSDA) was prepared, purified and crystallised in a form of black lustrous crystals, and its absorption and fluorescence spectra were recorded in cyclohexane, acetonitrile and dimethyl sulfoxide. Non-emissive intramolecular charge transfer state (ICT) was clearly observed in this molecule in all three solvents. Theoretical...

Delay-Dependent Exponential Stability for Discrete-Time BAM Neural Networks with Time-Varying Delays

This paper considers the delay-dependent exponential stability for discrete-time BAM neural networks with time-varying delays. By constructing the new Lyapunov functional, the improved delay-dependent exponential stability criterion is derived in terms of linear matrix inequality (LMI). Moreover, in order to reduce the conservativeness, some slack matrices are introduced in this...

Connective Tissue Fibroblast Properties Are Position-Dependent during Mouse Digit Tip Regeneration

A key factor that contributes to the regenerative ability of regeneration-competent animals such as the salamander is their use of innate positional cues that guide the regeneration process. The limbs of mammals has severe regenerative limitations, however the distal most portion of the terminal phalange is regeneration competent. This regenerative ability of the adult mouse...

Hoxc10 and Hoxd10 regulate mouse columnar, divisional and motor pool identity of lumbar motoneurons

Yuanyuan Wu Guoying Wang Sheryl A. Scott Mario R. Capecchi A central question in neural development is how the broad diversity of neurons is generated in the vertebrate CNS. We have investigated the

Modeling the role of p53 pulses in DNA damage- induced cell death decision

Background The tumor suppressor p53 plays pivotal roles in tumorigenesis suppression. Although oscillations of p53 have been extensively studied, the mechanism of p53 pulses and their physiological roles in DNA damage response remain unclear. Results To address these questions we presented an integrated model in which Ataxia-Telangiectasia Mutated (ATM) activation and p53...

1′-Acetoxychavicol acetate suppresses angiogenesis-mediated human prostate tumor growth by targeting VEGF-mediated Src-FAK-Rho GTPase-signaling pathway

Cancer therapeutic agents that are safe, effective and affordable are urgently needed. We describe that 1′-acetoxychavicol acetate (ACA), a component of Siamese ginger (Languas galanga), can suppress prostate tumor growth by largely abrogating angiogenesis. ACA suppressed vascular endothelial growth factor (VEGF)-induced proliferation, migration, adhesion and tubulogenesis of...

Cucurbitacin E, a tetracyclic triterpenes compound from Chinese medicine, inhibits tumor angiogenesis through VEGFR2-mediated Jak2–STAT3 signaling pathway

Cucurbitacin E (CuE, α-elaterin), a tetracyclic triterpenes compound from folk traditional Chinese medicine plants, has been shown to inhibit cancer cell growth, inflammatory response and bilirubin–albumin binding. However, the effects of CuE on tumor angiogenesis and its potential molecular mechanism are still unknown. Here, we demonstrated that CuE significantly inhibited human...

The radiosensitizing effect of doranidazole on human colorectal cancer cells exposed to high doses of irradiation

Background This paper investigates the effects of a new radiosensitizer, doranidazole, and enhancing irradiation on colorectal cancer cells. Methods The radiosensitizing effect of doranidazole was determined using colony formation and propidium iodide (PI) assays to measure cell growth inhibition and the cell killing effect of human colorectal cancer cell lines exposed to high...