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Self-Adaptive -Means Based on a Covering Algorithm

The -means algorithm is one of the ten classic algorithms in the area of data mining and has been studied by researchers in numerous fields for a long time. However, the value of the clustering number in the -means algorithm is not always easy to be determined, and the selection of the initial centers is vulnerable to outliers. This paper proposes an improved -means clustering...

Vitamin C increases 5-hydroxymethylcytosine level and inhibits the growth of bladder cancer

Background5-Hydroxymethylcytosine (5hmC) is converted from 5-methylcytosine (5mC) by a group of enzymes termed ten-eleven translocation (TET) family dioxygenases. The loss of 5hmC has been identified as a hallmark of most types of cancer and is related to tumorigenesis and progression. However, the role of 5hmC in bladder cancer is seldom investigated. Vitamin C was recently...

A long non-coding RNA HOTTIP expression is associated with disease progression and predicts outcome in small cell lung cancer patients

Despite progress in treatment of small cell lung cancer (SCLC), the biology of the tumor still remains poorly understood. Recently, we globally investigated the contributions of lncRNA in SCLC with a special focus on sponge regulatory network. Here we report lncRNA HOTTIP, which is specifically amplified in SCLC, is associated with SCLC proliferation and poor prognosis of...

Management of the soybean cyst nematode Heterodera glycines with combinations of different rhizobacterial strains on soybean

suggestions on the manuscript. 12 / 14 Author Contributions Conceptualization: Xiaofeng Zhu, Xiaoyu Liu, Yuxi Duan. Data curation: Yuanyuan Zhou, Yuanyuan Wang, Xiaofeng Zhu. Formal analysis: Yuanyuan Zhou ... , Rui Liu, Peng Xiang. Funding acquisition: Yuxi Duan, Lijie Chen. Investigation: Yuanyuan Zhou, Peng Xiang, Jingsheng Chen. Methodology: Yuanyuan Zhou, Yuxi Duan. Project administration: Yuxi Duan

Preparation of a nano- and micro-fibrous decellularized scaffold seeded with autologous mesenchymal stem cells for inguinal hernia repair

Preparation of a nano- and micro-fibrous decellularized scaffold seeded with autologous mesenchymal stem cells for inguinal hernia repair Yinlong Zhang,1,* Yuanyuan Zhou,1,* Xu Zhou,2,* Bin Zhao,1

Fabrication of compact and stable perovskite films with optimized precursor composition in the fast-growing procedure

The fast-growing procedure (FGP) provides a simple, high-yield and lead (Pb)-release free method to prepare perovskite films. In the FGP, the ultra-dilute perovskite precursor solution is drop-cast onto a hot (~240°C) substrate, where a perovskite film grows immediately accompanied by the rapid evaporation of the host solvent. In this process, all the raw materials in the...

Greener synthesis of electrospun collagen/hydroxyapatite composite fibers with an excellent microstructure for bone tissue engineering

Greener synthesis of electrospun collagen/hydroxyapatite composite fibers with an excellent microstructure for bone tissue engineering Yuanyuan Zhou,1,2 Hongchang Yao,1 Jianshe Wang,1 Dalu Wang,1

Comparison of Aortic Annulus Diameter Measurement between Multi-Detector Computed Tomography and Echocardiography: A Meta-Analysis

Zhou 0 Lulu Sun 0 Yiqing Song, Brigham & Women's Hospital, and Harvard Medical School, United States of America 0 Department of Ultrasound, the First Affiliated Hospital of Zhengzhou University

Transcriptomic analysis reveals key regulators of mammogenesis and the pregnancy-lactation cycle

An organ unique to mammals, the mammary gland develops 90% of its mass after birth and experiences the pregnancylactation-involution cycle (PL cycle) during reproduction. To understand mammogenesis at the transcriptomic level and using a ribo-minus RNA-seq protocol, we acquired greater than 50 million reads each for the mouse mammary gland during pregnancy (day 12 of pregnancy...

Pharmacokinetic Compatibility of Ginsenosides and Schisandra Lignans in Shengmai-san: From the Perspective of P-Glycoprotein

Background Phytochemical-mediated alterations in P-glycoprotein (P-gp) activity may result in herb-drug interactions by altering drug pharmacokinetics. Shengmai-san, a traditional Chinese herbal medicine composed by Panax Ginseng, Ophiopogon Japonicus, and Schisandra Chinensis, is routinely being used for treating various coronary heart diseases. In our previous studies...

Artemisinin derivative artesunate induces radiosensitivity in cervical cancer cells in vitro and in vivo

Objective Cervical cancer is the third most common type of cancer in women worldwide and radiotherapy remains its predominant therapeutic treatment. Artesunate (ART), a derivative of artemisinin, has shown radiosensitization effect in previous studies. However, such effects of ART have not yet been revealed for cervical cancer cells. Methods The effect of ART on radiosensitivity...

Transcriptome profiling of the developing postnatal mouse testis using next-generation sequencing

Mammalian testis development is a complex and highly sophisticated process. To study the dynamic change of normal testis development at the transcriptional level, we investigated mouse testes at three postnatal ages: 6 days postnatal, 4 weeks old, and 10 weeks old, representing infant (PN1), juvenile (PN2), and adult (PN3) stages, respectively. Using ultra high-throughput RNA...

Genetic variation and metabolic pathway intricacy govern the active compound content and quality of the Chinese medicinal plant Lonicera japonica thunb

BackgroundTraditional Chinese medicine uses various herbs for the treatment of various diseases for thousands of years and it is now time to assess the characteristics and effectiveness of these medicinal plants based on modern genetic and molecular tools. The herb Flos Lonicerae Japonicae (FLJ or Lonicera japonica Thunb.) is used as an anti-inflammatory agent but the chemical...