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Classification of optic disc shape in glaucoma using machine learning based on quantified ocular parameters

Conceptualization: Kazuko Omodaka, Toru Nakazawa. Data curation: Kazuko Omodaka, Satoru Tsuda, Yukihiro Shiga, Naoko Takada, Hidetoshi Takahashi. Formal analysis: Kazuko Omodaka. Funding acquisition: Toru Nakazawa ... . Investigation: Kazuko Omodaka, Satoru Tsuda, Yukihiro Shiga, Naoko Takada, Hidetoshi Takahashi. Methodology: Guangzhou An, Tsutomu Kikawa, Hideo Yokota, Masahiro Akiba. Supervision: Hideo Yokota, Toru Nakazawa

Preperimetric Glaucoma Prospective Observational Study (PPGPS): Design, baseline characteristics, and therapeutic effect of tafluprost in preperimetric glaucoma eye

, Etsuyo Miyamoto, Masayo Hashimoto, Toru Nakazawa. Data curation: Naoko Aizawa, Yukihiro Shiga, Satoru Tsuda, Yu Yokoyama, Kazuko Omodaka, Tomoki Yasui, Keiichi Kato. Formal analysis: Naoko Aizawa ... , Yukihiro Shiga, Satoru Tsuda, Yu Yokoyama, Kazuko Omodaka. Funding acquisition: Tomoki Yasui, Keiichi Kato, Hiroaki Kurashima, Etsuyo Miyamoto, Masayo Hashimoto. Investigation: Naoko Aizawa, Yukihiro

Usefulness of axonal tract-dependent OCT macular sectors for evaluating structural change in normal-tension glaucoma

assistance. Author Contributions Conceptualization: Toru Nakazawa. Data curation: Kazuko Omodaka, Yukihiro Shiga, Satoru Tsuda, Yu Yokoyama, Haruka Sato, Junko Ohuchi, Hidetoshi Takahashi. Funding ... acquisition: Toru Nakazawa. Investigation: Yukihiro Shiga, Satoru Tsuda. Methodology: Tsutomu Kikawa, Akiko Matsumoto, Masahiro Akiba. Project administration: Toru Nakazawa. Writing ± original draft: Kazuko

Traditional medicine as a potential treatment for Flammer syndrome

, Aoba ward, Sendai 980-8575 , Japan 1 Department of Kampo Medicine, Tohoku University Hospital , 1-1 Seiryo-machi, Aoba ward, Sendai 980-8574 , Japan 2 Yukihiro Shiga 3 Shin Takayama 4 Department of

Genetic analysis of Japanese primary open-angle glaucoma patients and clinical characterization of risk alleles near CDKN2B-AS1, SIX6 and GAS7

Technology Agency, JST. The manuscript has been proof read by an English editing service (Enago Ltd., Tokyo, Japan). Author Contributions Conceptualization: Yukihiro Shiga, Koji M. Nishiguchi, Yosuke Kawai ... , Jun Yasuda, Masao Nagasaki, Toru Nakazawa. Data curation: Yukihiro Shiga, Yosuke Kawai, Kaname Kojima, Masao Nagasaki. Formal analysis: Yukihiro Shiga, Yosuke Kawai, Kaname Kojima, Masao Nagasaki

Additive effects of genetic variants associated with intraocular pressure in primary open-angle glaucoma

, Zentaro Yamagata, Mitsuko Takamoto, Makoto Aihara, Take shi Iwata, Kazuhide Kawase, Yukihiro Shiga, Koji M. Nishiguchi, Toru Nakazawa, Mineo Ozaki, Makoto Araie. 11 / 13 12 / 13 1. Keltner JL , Johnson

Age- and Sex-Dependency of Laser Speckle Flowgraphy Measurements of Optic Nerve Vessel Microcirculation

Purpose To investigate the relationship between various characteristics of a normal population and laser speckle flowgraphy (LSFG) measurements of mean blur rate (MBR) in the optic nerve head (ONH). Methods A total of 189 eyes of 189 normal subjects (93 male, 96 female, mean age 45 ± 14 years old, age range: 20–72) without any history of hypertension, hyperlipidemia or diabetes...

OCT-Based Quantification and Classification of Optic Disc Structure in Glaucoma Patients

Purpose To objectively classify the optic discs of open-angle glaucoma (OAG) patients into Nicolela's four disc types, i.e., focal ischemic (FI), myopic (MY), senile sclerotic (SS), and generalized enlargement (GE), with swept-source optical coherence tomography (SS-OCT). Methods This study enrolled 113 eyes of 113 OAG patients (mean age: 62.5 ± 12.6; Humphrey field analyzer...

3D Evaluation of the Lamina Cribrosa with Swept-Source Optical Coherence Tomography in Normal Tension Glaucoma

Purpose Although the lamina cribrosa (LC) is the primary site of axonal damage in glaucoma, adequate methods to image and measure it are currently lacking. Here, we describe a noninvasive, in vivo method of evaluating the LC, based on swept-source optical coherence tomography (SS-OCT), and determine this method’s ability to quantify LC thickness. Methods This study comprised 54...

Correlation between structure/function and optic disc microcirculation in myopic glaucoma, measured with laser speckle flowgraphy

Background It is difficult to identify glaucoma in myopic eyes because the configuration of the optic disc varies; yet it is important clinically. Here, we used laser speckle flowgraphy (LSFG) to measure mean blur rate (MBR), representing optic disc microcirculation, and assessed its ability to identify glaucoma in eyes with myopic optic discs. Methods 129 eyes (normal disc: 21...