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Usefulness of axonal tract-dependent OCT macular sectors for evaluating structural change in normal-tension glaucoma

assistance. Author Contributions Conceptualization: Toru Nakazawa. Data curation: Kazuko Omodaka, Yukihiro Shiga, Satoru Tsuda, Yu Yokoyama, Haruka Sato, Junko Ohuchi, Hidetoshi Takahashi. Funding ... acquisition: Toru Nakazawa. Investigation: Yukihiro Shiga, Satoru Tsuda. Methodology: Tsutomu Kikawa, Akiko Matsumoto, Masahiro Akiba. Project administration: Toru Nakazawa. Writing ± original draft: Kazuko

Additive effects of genetic variants associated with intraocular pressure in primary open-angle glaucoma

, Zentaro Yamagata, Mitsuko Takamoto, Makoto Aihara, Take shi Iwata, Kazuhide Kawase, Yukihiro Shiga, Koji M. Nishiguchi, Toru Nakazawa, Mineo Ozaki, Makoto Araie. 11 / 13 12 / 13 1. Keltner JL , Johnson

OCT-Based Quantification and Classification of Optic Disc Structure in Glaucoma Patients

Purpose To objectively classify the optic discs of open-angle glaucoma (OAG) patients into Nicolela's four disc types, i.e., focal ischemic (FI), myopic (MY), senile sclerotic (SS), and generalized enlargement (GE), with swept-source optical coherence tomography (SS-OCT). Methods This study enrolled 113 eyes of 113 OAG patients (mean age: 62.5 ± 12.6; Humphrey field ...

Age- and Sex-Dependency of Laser Speckle Flowgraphy Measurements of Optic Nerve Vessel Microcirculation

Purpose To investigate the relationship between various characteristics of a normal population and laser speckle flowgraphy (LSFG) measurements of mean blur rate (MBR) in the optic nerve head (ONH). Methods A total of 189 eyes of 189 normal subjects (93 male, 96 female, mean age 45 ± 14 years old, age range: 20–72) without any history of hypertension, hyperlipidemia or diabetes ...

3D Evaluation of the Lamina Cribrosa with Swept-Source Optical Coherence Tomography in Normal Tension Glaucoma

Purpose Although the lamina cribrosa (LC) is the primary site of axonal damage in glaucoma, adequate methods to image and measure it are currently lacking. Here, we describe a noninvasive, in vivo method of evaluating the LC, based on swept-source optical coherence tomography (SS-OCT), and determine this method’s ability to quantify LC thickness. Methods This study comprised 54 ...

Correlation between structure/function and optic disc microcirculation in myopic glaucoma, measured with laser speckle flowgraphy

Background It is difficult to identify glaucoma in myopic eyes because the configuration of the optic disc varies; yet it is important clinically. Here, we used laser speckle flowgraphy (LSFG) to measure mean blur rate (MBR), representing optic disc microcirculation, and assessed its ability to identify glaucoma in eyes with myopic optic discs. Methods 129 eyes (normal disc: 21 ...