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Disruption of the Circadian Clock Alters Antioxidative Defense via the SIRT1-BMAL1 Pathway in 6-OHDA-Induced Models of Parkinson’s Disease

Chen,2 Yun Shen,2 Fen Wang,3 Li-Fang Hu,3 and Chun-Feng Liu2,3 1Department of Neurology, Suzhou Municipal Hospital, Nanjing Medical University, Suzhou 215008, China 2Department of Neurology and Suzhou

Fabrication of depletion type micro-ring modulator with high extinction ratio and high coupling quality factor

We experimentally demonstrate an optical micro-ring modulator based on a reverse-biased PN junction which is integrated into a silicon-on-insulator (SOI) rib waveguide. The performance of micro-ring resonator with different sizes is simulated with Lumerical MODE Solutions. The fabricated device provides a high extinction ratio (ER) of 20 dB and coupling quality factor (Q) 2*104...

Effects of Vildagliptin Add-on Insulin Therapy on Nocturnal Glycemic Variations in Uncontrolled Type 2 Diabetes

approval for the version to be published. Jianhua Ma and Lei Ye contributed to the conception and design of the study. Feng-fei Li, Yun Shen, Rui Sun, Dan-feng Zhang, Mao-yuan Chen, and Xiao-fang Zhai ... version. We also express our appreciation to Prof. Frank Elliott, who contributed to the final proof of the manuscript. Disclosures. Feng-fei Li, Yun Shen, Rui Sun, Dan-feng Zhang, Xing Jin, Xiao-fang Zhai

Serum Soluble Corin Deficiency Predicts Major Disability within 3 Months after Acute Stroke

Objective Serum soluble corin has been associated with stroke. However, whether it is associated with stroke prognosis has not yet been studied. Therefore, we aimed to study the association of serum soluble corin with risk of poor outcomes within 3 months after stroke. Methods We followed 522 stroke patients for 3 months to identify major disability, death and vascular events...

Synthesis and Larvicidal Activity of Novel Thenoylhydrazide Derivatives

University, Guangzhou, 510642, ChinaGao-Peng Song, De-Kun Hu, Hao Tian, Ya-Sheng Li, Yun-Shen Cao & Zi-Ning CuiCollege of Materials and Energy, South China Agricultural University, Guangzhou 510642, ChinaGao ... in:Nature Research journals • PubMed • Google ScholarSearch for Yun-Shen Cao in:Nature Research journals • PubMed • Google ScholarSearch for Hong-Wei Jin in:Nature Research journals • PubMed • Google

Dynamic analysis of a high-speed train operating on a curved track with failed fasteners

Li ZHOU 0 Zhi-yun SHEN 0 0 (State Key Laboratory of Traction Power, Southwest Jiaotong University , Chengdu 610031, China) 1 Project supported by the National Natural Science Foundation of China (No

DNA methylation is critical for tooth agenesis: implications for sporadic non-syndromic anodontia and hypodontia

. AffiliationsDepartment of Stomatology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, No.301, Middle Yanchang Road, Shanghai 200072, P.R. ChinaJing Wang, Yun Shen, Yuanzhi Xu, Yiming Zhang ... , Renhuan Huang & Yunfeng Lin AuthorsSearch for Jing Wang in:Nature Research journals • PubMed • Google ScholarSearch for Ke Sun in:Nature Research journals • PubMed • Google ScholarSearch for Yun Shen

Positive Relationship between Serum Low-Density Lipoprotein Cholesterol Levels and Visceral Fat in a Chinese Nondiabetic Population

Background It has been reported that obesity and serum low-density lipoprotein cholesterol (LDL-c) are important risk factors of cardiovascular disease (CVD). It is recognized that regionalized adiposity has different cardiovascular risk, visceral versus subcutaneous, is a better predictor of CVD. However, the relationship between regionalized adiposity and LDL-c is unclear. The...

Cell type-specific expression of Eps8 in the mouse hippocampus

Background Epidermal growth factor receptor substrate 8 (Eps8) is a multifunctional protein that regulates actin cytoskeleton dynamics and architecture through its barbed-end capping and bundling activities. In cultured hippocampal neurons, Eps8 is enriched at dendritic spine heads and is required for spine morphogenesis; however, the detailed expression pattern of Eps8 in the...

Cryopreservation and replantation of amputated rat hind limbs

Background In spite of the relatively high success rate of limb replantation, many patients cannot undergo replantation surgery because the preservation time of an amputated limb is only about six hours. In addition, although allotransplantation of composite tissues is being performed more commonly with increasingly greater success rates, the shortage of donors limits the number...

The Arabidopsis RNA Binding Protein with K Homology Motifs, SHINY1, Interacts with the C-terminal Domain Phosphatase-like 1 (CPL1) to Repress Stress-Inducible Gene Expression

The phosphorylation state of the C-terminal domain (CTD) of the RNA polymerase II plays crucial roles in transcription and mRNA processing. Previous studies showed that the plant CTD phosphatase-like 1 (CPL1) dephosphorylates Ser-5-specific CTD and regulates abiotic stress response in Arabidopsis. Here, we report the identification of a K-homology domain-containing protein named...

Associations of Serum 25-Hydroxyvitamin D3 Levels with Visceral Adipose Tissue in Chinese Men with Normal Glucose Tolerance

Objective Decreased serum vitamin D level is a common observation in obese adults. Since no Chinese population-based study has yet evaluated the relationship between serum vitamin D levels and the accurate adiposity variables, this study investigated the association of serum vitamin D (assessed by 25-hydroxyvitamin D3 [25(OH)D3]) levels with precise body fat content and...

Additive relationship between serum fibroblast growth factor 21 level and coronary artery disease

Background Expression and activity of the fibroblast growth factor (FGF) 21 hormone-like protein are associated with development of several metabolic disorders. This study was designed to investigate whether serum FGF21 level was also associated with the metabolic syndrome-related cardiovascular disease, atherosclerosis, and its clinical features in a Chinese cohort. Methods Two...

Common variants in adiponectin gene are associated with coronary artery disease and angiographical severity of coronary atherosclerosis in type 2 diabetes

Background Adiponectin, an adipokine facilitating insulin action, has antiatherogenic effects. This study investigated whether common single nucleotide polymorphisms (SNPs) in the adiponectin gene influenced plasma adiponectin level and whether they were associated with the risk of coronary artery disease (CAD) and its angiographical severity in type 2 diabetes in Chinese...

Identification of Genomic Alterations in Pancreatic Cancer Using Array-Based Comparative Genomic Hybridization

Background Genomic aberration is a common feature of human cancers and also is one of the basic mechanisms that lead to overexpression of oncogenes and underexpression of tumor suppressor genes. Our study aims to identify frequent genomic changes in pancreatic cancer. Materials and Methods We used array comparative genomic hybridization (array CGH) to identify recurrent genomic...

Increased Cytokines Response in Patients with Tuberculosis Complicated with Chronic Obstructive Pulmonary Disease

Objectives To explore the change and its significance of cytokines in patients with pulmonary tuberculosis complicated with COPD. Methods The immune function of 152 cases of pulmonary tuberculosis with COPD was detected to compare with 150 cases of patients with pulmonary tuberculosis, 157 cases of patients with COPD and 50 cases of healthy volunteers who were in the hospital...

Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Belatacept in Adult Kidney Transplant Recipients

providing editorial support. Financial disclosures Janice Pursley, Eric Masson, Nadia McGirr, Elizabeth Proszynski, Yun Shen, Kathleen Soucek, Robert Townsend, Xiaoli You, and Zexun Zhou are employees of

The Rice RMR1 Associates with a Distinct Prevacuolar Compartment for the Protein Storage Vacuole Pathway

Transport of vacuolar proteins from Golgi apparatus or trans-Golgi network (TGN) to vacuoles is a receptor-mediated process via an intermediate membrane-bound prevacuolar compartment (PVC) in plant cells. Both vacuolar sorting receptor (VSR) and receptor homology region-transmembrane domain-RING-H2 (RMR) proteins have been shown to function in transporting storage proteins to...