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89 papers found.
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A sensitive and innovative detection method for rapid C-reactive proteins analysis based on a micro-fluxgate sensor system

) S3 File. Fabrication process of the Au film substrate. (DOC) Author Contributions Conceptualization: Lei Guo, Zhen Yang, Yong Zhou. Data curation: Lei Guo. Formal analysis: Lei Guo. Investigation ... : Lei Guo, Zhen Yang. Project administration: Yong Zhou. 14 / 17 Software: Shaotao Zhi, Zhu Feng, Chong Lei. Writing ± original draft: Lei Guo. Writing ± review & editing: Lei Guo. 15 / 17 16 / 17 1

Photokinetic Drug Delivery: Near infrared (NIR) Induced Permeation Enhancement of Bevacizumab, Ranibizumab and Aflibercept through Human Sclera

interest in the IP of the technology described. The authors Zhen-Yang Zhao, Kevin H. Merkley and Jiyang Cai have no competing interests. Open Access This article is distributed under the terms of the

Formulation Stabilization and Disaggregation of Bevacizumab, Ranibizumab and Aflibercept in Dilute Solutions

authors Steven A. Giannos and Edward R. Kraft own significant interest in the IP of the technology described. The authors Zhen-Yang Zhao, Kevin H. Merkley and Jiyang Cai have no competing interests. Open

Research on Vertical Coupling Dynamics of Monorail Vehicle at Finger-Band

In view of the fact that exhibits monorail transportation in recent years, the good situation and the lack of straddle-type monorail vehicle vertical dynamics research, the key problems of vertical vibration were studied in this paper: The vertical coupling is between walking tires and finger-band. A dynamic model based on the vertical equivalent stiffness of tire is proposed...

Research on the Influence of Straddle-Type Monorail’s Pantograph Head Parameter on Power Collection Quality

At present, the coupling relationship between the pantograph and catenary is not ideal for straddle-type monorail. The power collection quality is poor, and the wear of the contact strip of a pantograph is uneven. Therefore, the key problem of coupling relation between the pantograph and catenary is the dynamics of a pantograph–catenary system. This paper analyzed the modal of...

Isolation and functional analysis of fatty acid desaturase genes from peanut (Arachis hypogaea L.)

administration: Shanlin Yu. Resources: Zhimeng Zhang. Software: Mingna Chen, Zhen Yang. Supervision: Xiangyu Guan, Shanlin Yu. Validation: Lijuan Pan. Visualization: Mian Wang. Writing ± original draft

From pathogenesis to clinical application: insights into exosomes as transfer vectors in cancer

Exosomes are nanoscale extracellular membrane vesicles that are created by the fusion of an intracellular multivesicular body with the cell membrane. They are widely distributed in serum, urine, saliva and other biological fluids. As important transfer vectors for intercellular communication and genetic material, exosomes can stimulate target cells directly via receptor-mediated...

The potential of circulating tumor DNA methylation analysis for the early detection and management of ovarian cancer

Background Despite a myriad of attempts in the last three decades to diagnose ovarian cancer (OC) earlier, this clinical aim still remains a significant challenge. Aberrant methylation patterns of linked CpGs analyzed in DNA fragments shed by cancers into the bloodstream (i.e. cell-free DNA) can provide highly specific signals indicating cancer presence. Methods We analyzed 699...

dbDEMC 2.0: updated database of differentially expressed miRNAs in human cancers

MicroRNAs (miRNAs) are often deregulated in cancer and are thought to play an important role in cancer development. Large amount of differentially expressed miRNAs have been identified in various cancers by using high-throughput methods. It is therefore quite important to make a comprehensive collection of these miRNAs and to decipher their roles in oncogenesis and tumor...

Molecular targeted therapy for the treatment of gastric cancer

Despite the global decline in the incidence and mortality of gastric cancer, it remains one of the most common malignant tumors of the digestive system. Although surgical resection is the preferred treatment for gastric cancer, chemotherapy is the preferred treatment for recurrent and advanced gastric cancer patients who are not candidates for reoperation. The short overall...

Shifting Perceptual Weights in L2 Vowel Identification after Training

Difficulties with second-language vowel perception may be related to the significant challenges in using acoustic-phonetic cues. This study investigated the effects of perception training with duration-equalized vowels on native Chinese listeners’ English vowel perception and their use of acoustic-phonetic cues. Seventeen native Chinese listeners were perceptually trained with...

CXCR7/p-ERK-Signaling Is a Novel Target for Therapeutic Vasculogenesis in Patients with Coronary Artery Disease

Coronary artery disease (CAD) is characterized by insufficient vasculogenic response to ischemia, which is typically accompanied by dysfunction of endothelial outgrowth cells (EOCs). CXC chemokine receptor 7 (CXCR7) is a key modulator of the neovascularization of EOCs to perfusion defect area. However, the mechanism underlying the role of EOCs in CAD-related abnormal...

Perfluorocarbon reduces cell damage from blast injury by inhibiting signal paths of NF-κB, MAPK and Bcl-2/Bax signaling pathway in A549 cells

Background and objective Blast lung injury is a common type of blast injury and has very high mortality. Therefore, research to identify medical therapies for blast injury is important. Perfluorocarbon (PFC) is used to improve gas exchange in diseased lungs and has anti-inflammatory functions in vitro and in vivo. The aim of this study was to determine whether PFC reduces damage...

The multi-omic landscape of transcription factor inactivation in cancer

Background Hypermethylation of transcription factor promoters bivalently marked in stem cells is a cancer hallmark. However, the biological significance of this observation for carcinogenesis is unclear given that most of these transcription factors are not expressed in any given normal tissue. Methods We analysed the dynamics of gene expression between human embryonic stem cells...

Correlation of an epigenetic mitotic clock with cancer risk

Background Variation in cancer risk among somatic tissues has been attributed to variations in the underlying rate of stem cell division. For a given tissue type, variable cancer risk between individuals is thought to be influenced by extrinsic factors which modulate this rate of stem cell division. To date, no molecular mitotic clock has been developed to approximate the number...

Denoising perturbation signatures reveal an actionable AKT-signaling gene module underlying a poor clinical outcome in endocrine-treated ER+ breast cancer

Background Databases of perturbation gene expression signatures and drug sensitivity provide a powerful framework to develop personalized medicine approaches, by helping to identify actionable genomic markers and subgroups of patients who may benefit from targeted treatments. Results Here we use a perturbation expression signature database encompassing perturbations of over 90...

Identification and transcriptomic profiling of genes involved in increasing sugar content during salt stress in sweet sorghum leaves

Background Sweet sorghum is an annual C4 crop considered to be one of the most promising bio-energy crops due to its high sugar content in stem, yet it is poorly understood how this plant increases its sugar content in response to salt stress. In response to high NaCl, many of its major processes, such as photosynthesis, protein synthesis, energy and lipid metabolism, are...

An integrative pan-cancer-wide analysis of epigenetic enzymes reveals universal patterns of epigenomic deregulation in cancer

Background One of the most important recent findings in cancer genomics is the identification of novel driver mutations which often target genes that regulate genome-wide chromatin and DNA methylation marks. Little is known, however, as to whether these genes exhibit patterns of epigenomic deregulation that transcend cancer types. Results Here we conduct an integrative pan-cancer...