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A review on robotic fish enabled by ionic polymer–metal composite artificial muscles

A novel actuating material, which is lightweight, soft, and capable of generating large flapping motion under electrical stimuli, is highly desirable to build energy-efficient and maneuverable bio-inspired underwater robots. Ionic polymer–metal composites are important category of electroactive polymers, since they can generate large bending motions under low actuation voltages...

Understanding disciplinary vocabularies using a full-text enabled domain-independent term extraction approach

, Jake Williams, Zheng Chen. Methodology: Erjia Yan, Jake Williams, Zheng Chen. Project administration: Erjia Yan. Software: Zheng Chen. Visualization: Erjia Yan, Jake Williams. Writing ± original ... draft: Erjia Yan, Jake Williams, Zheng Chen. Writing ± review & editing: Erjia Yan, Jake Williams, Zheng Chen. 14 / 16 15 / 16 1. Merton RK . The Matthew effect in science . Science . 1968 ; 159 ( 3810

Pacific-North American teleconnection and North Pacific Oscillation: historical simulation and future projection in CMIP5 models

Based on reanalysis datasets and as many as 35 CMIP5 models, this study evaluates the capability of climate models to simulate the spatiotemporal features of Pacific-North American teleconnection (PNA) and North Pacific Oscillation (NPO) in the twentieth century wintertime, and further investigates their responses to greenhouse warming in the twenty-first century. Analysis...

Two new species of Oreocharis (Gesneriaceae) from Fan Si Pan, the highest mountain in Vietnam

Two new species of Oreocharis Benth. from Fan Si Pan, the highest mountain in Vietnam (Sa Pa) are described and illustrated. Oreocharis grandiflora W.H.Chen, Q.H.Nguyen & Y.M.Shui, is similar to O. flavida Merr. from Hainan province, China, but differs mainly by its larger and infundibuliform corolla, stamens adnate to the base of the corolla tube and stamens coherent in two...

Sex-specific mortality differences in heart failure patients with ischemia receiving cardiac resynchronization therapy

Xu. Data curation: Zhonglin Han, Zheng Chen, Wei Xu. Formal analysis: Zhonglin Han. Investigation: Zhonglin Han, Zheng Chen. Methodology: Zhonglin Han, Zheng Chen, Wei Xu. Project administration

miR-324-3p promotes gastric cancer development by activating Smad4-mediated Wnt/beta-catenin signaling pathway

, Wei-Zhi Wang, and Zheng Chen 3 Department of Surgery, Vanderbilt University Medical Center , Nashville, TN , USA Background Emerging evidence suggested that miRNAs can function as oncogenes or tumor

Hair Measurements of Cortisol, DHEA, and DHEA to Cortisol Ratio as Biomarkers of Chronic Stress among People Living with HIV in China: Known-Group Validation

Background Existing literature suggests that endocrine measures, including the steroid hormones of cortisol and Dehydroepiandrosterone (DHEA), as well as the DHEA to cortisol ratio in the human hair can be used as promising biomarkers of chronic stress among humans. However, data are limited regarding the validity of these measures as biomarkers of chronic stress among people...

Elevated Hair Cortisol Levels among Heroin Addicts on Current Methadone Maintenance Compared to Controls

Whether methadone maintenance treatment (MMT) can improve the basal function of the hypothalamic–pituitary–adrenal (HPA) axis, which is suppressed by long-term heroin consumption, is a matter of debate. The stress state and depression and anxiety symptoms may affect the basal activity of the HPA axis in MMT patients. However, the effect of psychological factors on HPA activity...

Integrative Analysis Using Module-Guided Random Forests Reveals Correlated Genetic Factors Related to Mouse Weight

Complex traits such as obesity are manifestations of intricate interactions of multiple genetic factors. However, such relationships are difficult to identify. Thanks to the recent advance in high-throughput technology, a large amount of data has been collected for various complex traits, including obesity. These data often measure different biological aspects of the traits of...

Statistical Inference Methods for Two Crossing Survival Curves: A Comparison of Methods

A common problem that is encountered in medical applications is the overall homogeneity of survival distributions when two survival curves cross each other. A survey demonstrated that under this condition, which was an obvious violation of the assumption of proportional hazard rates, the log-rank test was still used in 70% of studies. Several statistical methods have been...

Stem cell protein Piwil1 endowed endometrial cancer cells with stem-like properties via inducing epithelial-mesenchymal transition

Background Stem cell protein Piwil1 functions as an oncogene in various tumor types. However, the exact function and mechanism of Piwil1 in endometrial cancer remains unclear. Methods The expression of Piwil1 and its relationships with clinicopathological factors were investigated using immunohistochemistry. Up- or down-regulation of Piwil1 were achieved by stable or transient...

A long non-coding RNA, APOA4-AS, regulates APOA4 expression depending on HuR in mice

Long non-coding RNAs (lncRNAs) have been shown to be critical biomarkers or therapeutic targets for human diseases. However, only a small number of lncRNAs were screened and characterized. Here, we identified 15 lncRNAs, which are associated with fatty liver disease. Among them, APOA4-AS is shown to be a concordant regulator of Apolipoprotein A-IV (APOA4) expression. APOA4-AS has...

SATB1 Promotes Pancreatic Cancer Growth and Invasion Depending on MYC Activation

16 pairs of normal pancreatic/pancreatic cancer tissues using RT-PCR and western blot. SW1990 or Capan-1 cells stably Zheng Chen and Zengliang Li have been contributed equally to this work

Comparative studies of mitochondrial proteomics reveal an intimate protein network of male sterility in wheat (Triticum aestivum L.)

Plant male sterility has often been associated with mitochondrial dysfunction; however, the mechanism in wheat (Triticum aestivum L.) has not been elucidated. This study set out to probe the mechanism of physiological male sterility (PHYMS) induced by the chemical hybridizing agent (CHA)-SQ-1, and cytoplasmic male sterility (CMS) of wheat at the proteomic level. A total of 71...

Long-term culture and significant expansion of human Sertoli cells whilst maintaining stable global phenotype and AKT and SMAD1/5 activation

Background Sertoli cells play key roles in regulating spermatogenesis and testis development by providing structural and nutritional supports. Recent studies demonstrate that Sertoli cells can be converted into functional neural stem cells. Adult Sertoli cells have previously been considered the terminally differentiated cells with a fixed and unmodifiable population after...

Fourier Series Approximations to -Bounded Equatorial Orbits

The current paper offers a comprehensive dynamical analysis and Fourier series approximations of -bounded equatorial orbits. The initial conditions of heterogeneous families of -perturbed equatorial orbits are determined first. Then the characteristics of two types of -bounded orbits, namely, pseudo-elliptic orbit and critical circular orbit, are studied. Due to the ambiguity of...

Ammonia-lowering activities and carbamoyl phosphate synthetase 1 (Cps1) induction mechanism of a natural flavonoid

Objective Ammonia detoxification is essential for physiological well-being, and the urea cycle in liver plays a predominant role in ammonia disposal. Nobiletin (NOB), a natural dietary flavonoid, is known to exhibit various physiological efficacies. In the current study, we investigated a potential role of NOB in ammonia control and the underlying cellular mechanism. Materials...

Prostaglandin E2 (PGE2) promotes proliferation and invasion by enhancing SUMO-1 activity via EP4 receptor in endometrial cancer

Prostaglandin E2 (PGE2), a derivative of arachidonic acid, has been identified as a tumorigenic factor in many cancers in recent studies. Prostaglandin E synthase 2 (PTGES2) is an enzyme that in humans is encoded by the PTGES2 gene located on chromosome 9, and it synthesizes PGE2 in human cells. In our study, we selected 119 samples from endometrial cancer patients, with 50...

Preparation and in vitro antitumor effects of cytosine arabinoside-loaded genipin-poly-L-glutamic acid-modified bacterial magnetosomes

Preparation and in vitro antitumor effects of cytosine arabinoside-loaded genipin-poly-L-glutamic acid-modified bacterial magnetosomes Yuan-Gang Liu,1,2 Qing-Lei Dai,1 Shi-Bin Wang,1,2 Qiong-Jia Deng,1 Wen-Guo Wu,1,2 Ai-Zheng Chen1,2 1College of Chemical Engineering, 2Institute of Pharmaceutical Engineering, Huaqiao University, Xiamen, People’s Republic of China Abstract: To...