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Association between a frailty index based on common laboratory tests and QTc prolongation in older adults: the Rugao Longevity and Ageing Study

,5 Yong Wang,5 Guo-Ping Shi,5 Zheng-Dong Wang,5 Shun Yao,1–3 Xiao-Feng Wang,1–3 Xiao-Yan Jiang6–8 1Unit of Epidemiology, Ministry of Education Key Laboratory of Contemporary Anthropology, Fudan ... , People's republic of China 1 s tate Key l aboratory of g enetic engineering, s chool of l ife s ciences, Fudan University , s hanghai, People's r epublic of China 2 Zheng-Dong Wang 3 Unit of epidemiology

Double knockout of Bax and Bak from kidney proximal tubules reduces unilateral urethral obstruction associated apoptosis and renal interstitial fibrosis

Science and Technology (12DJ1400300), Shanghai Top Priority Key Clinical Disciplines Construction Project, the National Institutes of Health and Department of Veterans Administration of USA. Zheng Dong is a ... • Google ScholarSearch for Yunchao Su in:Nature Research journals • PubMed • Google ScholarSearch for Changlin Mei in:Nature Research journals • PubMed • Google ScholarSearch for Zheng Dong in:Nature

Gli3 silencing enhances cyclopamine suppressive effects on ovarian cancer

Gli3 silencing enhances cyclopamine suppressive effects on ovarian cancer Hai-Yan Liu, Zheng Dong Department of Gynecology, First Affiliated Hospital of Liaoning Medical College, Jinzhou, People’s

Reliability-Based Topology Optimization Using Stochastic Response Surface Method with Sparse Grid Design

A mathematical framework is developed which integrates the reliability concept into topology optimization to solve reliability-based topology optimization (RBTO) problems under uncertainty. Two typical methodologies have been presented and implemented, including the performance measure approach (PMA) and the sequential optimization and reliability assessment (SORA). To enhance...

Robust Topology Optimization Based on Stochastic Collocation Methods under Loading Uncertainties

A robust topology optimization (RTO) approach with consideration of loading uncertainties is developed in this paper. The stochastic collocation method combined with full tensor product grid and Smolyak sparse grid transforms the robust formulation into a weighted multiple loading deterministic problem at the collocation points. The proposed approach is amenable to implementation...

Heat Shock Protein 70 Prevents Hyperoxia-Induced Disruption of Lung Endothelial Barrier via Caspase-Dependent and AIF-Dependent Pathways

Exposure of pulmonary artery endothelial cells (PAECs) to hyperoxia results in a compromise in endothelial monolayer integrity, an increase in caspase-3 activity, and nuclear translocation of apoptosis-inducing factor (AIF), a marker of caspase-independent apoptosis. In an endeavor to identify proteins involved in hyperoxic endothelial injury, we found that the protein expression...

Copy number variants of ABCF1, IL17REL, and FCGR3A are associated with the risk of gout

., S.J., Y.W., Y.C., and Y.L. contributed reagents/materials/analysis tools. J.W., Z.D., H.Z., F.Z., and L.J. wrote the paper. Zheng Dong, Yuan Li, Jingru Zhou, Shuai Jiang, Yi Wang, Yulin Chen, Dongbao ... give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Zheng Dong and Yuan Li have contributed equally

Gene Expression Analysis Indicates Divergent Mechanisms in DEN-Induced Carcinogenesis in Wild Type and Bid-Deficient Livers

Bid is a Bcl-2 family protein. In addition to its pro-apoptosis function, Bid can also promote cell proliferation, maintain S phase checkpoint, and facilitate inflammasome activation. Bid plays important roles in tissue injury and regeneration, hematopoietic homeostasis, and tumorigenesis. Bid participates in hepatic carcinogenesis but the mechanism is not fully understood...

Exploration of pathological prediction of chronic kidney diseases by a novel theory of bi-directional probability

• Google ScholarSearch for Fang Xiao in:Nature Research journals • PubMed • Google ScholarSearch for Hong Liu in:Nature Research journals • PubMed • Google ScholarSearch for Zheng Dong in:Nature Research ... AffiliationsDepartment of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, ChinaYuan Yang, Min Luo, Li Xiao, Xue-jing Zhu, Chang Wang, Xiao Fu, Shu-guang Yuan, Hong Liu, Zheng

Clinical and neuropsychological characteristics of general paresis misdiagnosed as primary psychiatric disease

Background Neurosyphilis is caused by the invasion of Treponema pallidum into the central nervous system. General paresis (GP) is a type of neurosyphilis. The main manifestation of general paresis is dementia; however, this is different from the other types of dementia, which can be cured by adequate doses of penicillin in the early stage. Neurosyphilis is the “great imitator...

Changes in Metabolic Profiles during Acute Kidney Injury and Recovery following Ischemia/Reperfusion

Changes of metabolism have been implicated in renal ischemia/reperfusion injury (IRI). However, a global analysis of the metabolic changes in renal IRI is lacking and the association of the changes with ischemic kidney injury and subsequent recovery are unclear. In this study, mice were subjected to 25 minutes of bilateral renal IRI followed by 2 hours to 7 days of reperfusion...

RETRACTED ARTICLE: Establishing an osteosarcoma associated protein-protein interaction network to explore the pathogenesis of osteosarcoma

Bi-Yong Deng 0 Ying-Qi Hua 0 Zheng-Dong Cai 0 0 Department of Orthopedic Surgery, Shanghai Tenth people's Hospital, Tongji University School of Medicine , No.301 Middle Yan-Chang Road, Zha-Bei

Determination of the apoptotic index in osteosarcoma tissue and its relationship with patients prognosis

Background Nowadays it remains a controversial issue whether a correlation exists between the apoptosis rate of tumor tissue and the prognosis of the patients. We aimed to explore the prognostic significance of apoptosis index of human osteosarcoma tissue. Methods The technique of terminal DNA breakpoints in situ 3 - hydroxy end labeling (TUNEL) was used to detect and analysis...

Co-infusion of haplo-identical CD19-chimeric antigen receptor T cells and stem cells achieved full donor engraftment in refractory acute lymphoblastic leukemia

Background Elderly patients with relapsed and refractory acute lymphoblastic leukemia (ALL) have poor prognosis. Autologous CD19 chimeric antigen receptor-modified T (CAR-T) cells have potentials to cure patients with B cell ALL; however, safety and efficacy of allogeneic CD19 CAR-T cells are still undetermined. Case presentation We treated a 71-year-old female with relapsed and...

Regulation of the high-affinity copper transporter (hCtr1) expression by cisplatin and heavy metals

Platinum-based antitumor agents have been the mainstay in cancer chemotherapy for many human malignancies. Drug resistance is an important obstacle to achieving the maximal therapeutic efficacy of these drugs. Understanding how platinum drugs enter cells is of great importance in improving therapeutic efficacy. It has been demonstrated that human high-affinity copper transporter...

Paclitaxel attenuates renal interstitial fibroblast activation and interstitial fibrosis by inhibiting STAT3 signaling

Yang,3 Xudong Xiang,1 Zhibiao He,1 Yu Zhao,4 Zheng Dong,2,5 Dongshan Zhang11Department of Emergency Medicine, 2Department of Nephrology, 3Department of Minimally Invasive Surgery, Second Xiangya Hospital

Gabapentin Effects on PKC-ERK1/2 Signaling in the Spinal Cord of Rats with Formalin-Induced Visceral Inflammatory Pain

Currently, the clinical management of visceral pain remains unsatisfactory for many patients suffering from this disease. While preliminary animal studies have suggested the effectiveness of gabapentin in successfully treating visceral pain, the mechanism underlying its analgesic effect remains unclear. Evidence from other studies has demonstrated the involvement of protein...

Association of VDR and CYP2R1 Polymorphisms with Mite-Sensitized Persistent Allergic Rhinitis in a Chinese Population

As recent studies have described an association between vitamin D and allergic rhinitis, we hypothesized that vitamin D pathway-related genes may be candidate genes for susceptibility to allergic rhinitis. Thus, we sought to evaluate whether polymorphisms in the vitamin D receptor (VDR) and CYP2R1 genes are associated with mite-sensitized persistent allergic rhinitis (PER) in a...