any of the authors. Correspondence and requests for materials should be addressed to Zheng-Dong Li. Reprints and permission information is available at http://www.nature.com/reprints Publisher’s note
and requests for materials should be addressed to Zheng-Dong Luo, Xuetao Gan or Yan Liu. Peer review information Nature Communications thanks Woo Jong Yu, and the other, anonymous, reviewers for their
Acute lung injury and its severe form acute respiratory distress syndrome are lethal lung diseases. So far, effective therapy for the diseases is deficient and the prognosis is poor. Recently, it was found activating nuclear factor erythroid 2-related factor 2 could attenuate the injury including inflammation, oxidative stress, and apoptosis in those diseases. To discover novel...
The semitauonic $$ {B}_c^{-}\to J/\psi {\tau}^{-}{\overline{\nu}}_{\tau } $$ decay provides an ideal and clean mode to scrutinize possible new physics effects in $$ b\to c{\tau}^{-}{\overline{\nu}}_{\tau } $$ transitions as indicated by the current data on R(D(*)) anomalies. In this work, we use the spin density matrix method to obtain the maximum information on the underlying...
In the era of big data, an ocean of data generated by Internet of Things (IoT) devices will be analyzed and processed by cloud computing. However, outsourcing of data can lead to leakage of user privacy to those unreliable service providers. In this paper, we propose a novel privacy-preserving scheme for IoT device by employing privacy set intersection (PSI) and blockchain...
- Zheng-Dong Zhao, Li Zhang, and Xinkuan Xiang contributed equally to this review. sensory processing, sensorimotor transformation, motivation, and sequential encoding of hunting actions. We also discuss
Ventilator-induced lung injury (VILI) is caused by overdistension of the alveoli by the repetitive recruitment and derecruitment of alveolar units. This study aims to investigate the potential role and mechanism of fibroblast growth factor 21 (FGF21), a metabolic regulator secreted by the liver, in VILI development. Serum FGF21 concentrations were determined in patients...
Alzheimer’s disease (AD) is the most common age-related neurodegenerative disorder. Emerging evidence suggests that synaptic dysfunction is associated with the onset and progression of AD. Interestingly, Ginkgo biloba extract (EGb) is one of the most frequently investigated herbal medicines for enhancing cognition and alleviating neurodegenerative dementia. This study aimed to...
To explore the role of calpain and its signaling pathway in lipopolysaccharide (LPS)-induced acute kidney injury (AKI), animal models of endotoxemia were established by administration of LPS to mice with endothelial-specific Capn4 knockout (TEK/Capn4−/−), mice with calpastatin (an endogenous calpain inhibitor) overexpression (Tg-CAST) and mice with myeloid-specific Capn4 knockout...
kidney injury: a cohort study Yi‑Yi Shi1†, Rui Zheng2†, Jie‑Jie Cai2, Zheng‑Dong Fang3, Wen‑Jing Chen3, Jing‑Ye Pan2,4* and Song‑Zan Qian2,4* Abstract Background: The relationship between fibrosis-4 (FIB
Sequential encoding of motor programs is essential for behavior generation. However, whether it is critical for instinctive behavior is still largely unknown. Mouse hunting behavior typically contains a sequential motor program, including the prey search, chase, attack, and consumption. Here, we reveal that the neuronal activity in the lateral periaqueductal gray (LPAG) follows a...
Clinically, it is difficult to endow implants with excellent osteogenic ability and antibacterial activity simultaneously. Herein, the self-activating implants modified with hydroxyapatite (HA)/MoS2 coating are designed to prevent Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) infections and accelerate bone regeneration simultaneously. The electron transfer...
Inflammation is one of the main pathological features leading to skin fibrosis and a key factor leading to the progression of skin fibrosis. Acidosis caused by a decrease in extracellular pH is a sign of the inflammatory process. Acid-sensing ion channels (ASICs) are ligand-gated ion channels on the cell membrane that sense the drop in extracellular pH. The molecular mechanisms...
Nonmagnetic Rashba systems with broken inversion symmetry are expected to exhibit nonreciprocal charge transport, a new paradigm of unidirectional magnetoresistance in the absence of ferromagnetic layer. So far, most work on nonreciprocal transport has been solely limited to cryogenic temperatures, which is a major obstacle for exploiting the room-temperature two-terminal devices...
Autophagy is an intracellular lysosomal degradative pathway important for tumor surveillance. Autophagy deficiency can lead to tumorigenesis. Autophagy is also known to be important for the aggressive growth of tumors, yet the mechanism that sustains the growth of autophagy-deficient tumors is not unclear. We previously reported that progression of hepatic tumors developed in...
Pathological cardiac hypertrophy eventually leads to heart failure without adequate treatment. REGγ is emerging as 11S proteasome activator of 20S proteasome to promote the degradation of cellular proteins in a ubiquitin- and ATP-independent manner. Here, we found that REGγ was significantly upregulated in the transverse aortic constriction (TAC)-induced hypertrophic hearts and...
Cadmium (Cd) accumulation in rice is a serious threat to food safety and human health. Breeding rice varieties with low Cd accumulation is one of the most effective approaches to reducing health risks from Cd-polluted rice. However, the genetic basis of Cd accumulation in grains, especially in indica rice varieties, has not been fully elucidated. The evaluation of Cd-accumulation...
Gaetano Romano Yong-jun Guan,1 Shi-ying Fang,2 Lin-lin Chen,3 Zheng-dong Li2,3 1Department of General Surgery, Yan Da International Hospital, Langfang, Hebei 065000, China; 2Department of
the emergency PCI operation Ping Li1 na1, Jiang-Wen Ruan1 na1, Ming Liu1 na2, Si-Yao Li1 na2, Zheng-Dong Wang1 na2 & Wen-Chao Xie1 na2 Journal of Cardiothoracic Surgery volume 14, Article number: 172 ... Ruan Ruan contribute euqually, both as the first authors. Ming Liu, Zheng-Dong Wang, Wen-Chao Xie and Si-Yao Li contribute equally, all as the second auhtors. AffiliationsDepartment of Cardiology, Yulin
Magneto-electric (ME) dipole antennas, with the function of changing the antenna characteristics, such as frequency, polarization, or radiation patterns, are reviewed in this paper. The reconfigurability is achieved by electrically altering the states of diodes or varactors to change the surface currents distributions or reflector size of the antenna. The purpose of the designs...
