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Preliminary fast diagnosis of severe fever with thrombocytopenia syndrome with clinical and epidemiological parameters

Objectives To identify specific clinical and epidemiological parameters for clinical diagnosis of SFTSV infection with relatively higher accuracy. Methods 231 suspected cases of SFTS were reported by various medical institutions from 2011 to 2013 in Jiangsu Province, China. They were followed with SFTSV diagnosis tests and interview-administered questionnaires about demographic...

PD-1 Antibody Monotherapy for Malignant Melanoma: A Systematic Review and Meta-Analysis

Antibodies targeting programmed death 1 (PD-1) help prevent tumor cells from escaping immune-mediated destruction. We conducted this systematic review and meta-analysis to gain insight into the efficacy of PD-1 antibodies for the treatment of melanoma. Five trials involving 2,828 adult patients were included in this meta-analysis. In patients with previously untreated or...

Theoretical study of the effects of different substituents of tetrathiafulvalene derivatives on charge transport

Density functional theory calculations were carried out to investigate the charge transfer of four tetrathiafulvalene derivatives. Perfluorination of dibenzo-tetrathiafulvalene (DB-TTF) increased the reorganization energy and was considered disadvantageous for the charge-transport process. Fluorination lowered the frontier orbitals of the compound, favoring electron—rather than...

Theoretical characterization of single-electron iodine-bond weak interactions in CH3…I-Y(Y = BH2, H, CH3, C2H3, C2H, CN, NC) systems

Iodine-involved single-electron halogen bonds (SEXBs) weak interactions in the systems of CH3…I-Y(Y = BH2, H, CH3, CH=CH2, C≡CH, CN, NC) were investigated for the first time using B3LYP/6-311++G(d,p) and MP2/aug-cc-pVTZ computational levels (the relativistic effective core potential basis set of Lanl2dz was used on iodine atom). The interaction energies between two moieties with...

MPprimer: a program for reliable multiplex PCR primer design

Background Multiplex PCR, defined as the simultaneous amplification of multiple regions of a DNA template or multiple DNA templates using more than one primer set (comprising a forward primer and a reverse primer) in one tube, has been widely used in diagnostic applications of clinical and environmental microbiology studies. However, primer design for multiplex PCR is still a...

Sepsis 2016 Agra, India

immune system Zhifeng Li, Dennis Grech, Patrick Morcillo, Alex Bekker, Luis Ulloa P7 Pathway-level meta-analysis reveals transcriptional signature of septic shock Samanwoy Mukhopadhyay, Abhay D Pandey ... , Kalyani, 741251 , India National Institute of Biomedical Genomics , Kalyani, 741251 , India Critical Care 2016, 20(Suppl 1):P7 6 P6 Translational neuromodulation of the immune system Zhifeng Li, Dennis

Transcription and splicing regulation in human umbilical vein endothelial cells under hypoxic stress conditions by exon array

Background The balance between endothelial cell survival and apoptosis during stress is an important cellular process for vessel integrity and vascular homeostasis, and it is also pivotal in angiogenesis during the development of many vascular diseases. However, the underlying molecular mechanisms remain largely unknown. Although both transcription and alternative splicing are...