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Identification of critical base pairs required for CTCF binding in motif M1 and M2

Natural Science Funds (2015A030308003, 2015A030310041 and 2016A030313168), Guangzhou Science Technology and Innovation Commission, Dr. Zhibin Wang is supported by NIH/NIEHS R01ES025761 and the One Hundred ... , Jiao Li, Zhibin Wang, and Hongjie Yao declare that they have no conflict of interest. This letter does not contain any studies with human or animal subjects performed by the any of the authors. Wufeng

Bacteria endocarditis consolidation with vertebra bone tuberculosis: a case report

Background The clinical features of bacteria endocarditis became atypical when consolidated with other conditions such as tuberculosis (TB). Especially, the symptoms of bacteria endocarditis (BE) which were hidden behind the TB fever often lead to misdiagnosis and missed diagnosis. Case presentation A 56-year-old male with thoracic vertebra bone TB history presented with low-grade ...

Quantitative evaluation of longitudinal strain in layer-specific myocardium during normal pregnancy in China

Background The myocardial wall of the left ventricle is a complex, multilayered structure and is not homogenous. The aim of this study was to determine longitudinal strain (LS) in the three myocardial layers in normal pregnant women according to gestation proceedings. Methods The advanced two-dimensional speckle tracking echocardiography (2D STE) was performed on 62 women during ...

Histone Modification Patterns and Their Responses to Environment

because of space limitations. Compliance with Ethics Guidelines Conflict of Interest Hongzheng Dai1 and Zhibin Wang declare that they have no conflict of interest. Human and Animal Rights and Informed

Erratum to: On secondary new particle formation in China

WANG Zhijun WU Lin WANG Douglas R. WORSNOP Markku Kulmala Tuukka Petäjä Veli-Matti Kerminen Joni Kujansuu Taina Ruuskanen Aijun Ding Wei Nie Min Hu Zhibin Wang Zhijun Wu Lin Wang Douglas R. Worsnop The

An essential role for UTX in resolution and activation of bivalent promoters

Trimethylated histone H3 lysine 27 (H3K27me3) is linked to gene silencing, whereas H3K4me3 is associated with gene activation. These two marks frequently co-occupy gene promoters, forming bivalent domains. Bivalency signifies repressed but activatable states of gene expression and can be resolved to active, H3K4me3-prevalent states during multiple cellular processes, including ...

Distinct roles of DNMT1-dependent and DNMT1-independent methylation patterns in the genome of mouse embryonic stem cells

MR is always 0.67. Extremely high coverage is required to completely remove PCR bias (unpublished data, Dr. Zhibin Wang at Bloomberg School of Public Health, Johns Hopkins University). Usually, about

Biocompatibility of nano-hydroxyapatite/Mg-Zn-Ca alloy composite scaffolds to human umbilical cord mesenchymal stem cells from Wharton’s jelly in vitro

Seeding cells and scaffolds play pivotal roles in bone tissue engineering and regenerative medicine. Wharton’s jelly-derived mesenchymal stem cells (WJCs) from human umbilical cord represent attractive and promising seeding cells in tissue regeneration and engineering for treatment applications. This study was carried out to explore the biocompatibility of scaffolds to seeding ...

Determination of enriched histone modifications in non-genic portions of the human genome

Background Chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) has recently been used to identify the modification patterns for the methylation and acetylation of many different histone tails in genes and enhancers. Results We have extended the analysis of histone modifications to gene deserts, pericentromeres and subtelomeres. Using data from human CD4+ ...