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Comparison of two cannulation methods for assessment of intracavernosal pressure in a rat model

. Software: Lianmin Luo. Supervision: ShawPong Wan. Validation: Jiamin Wang. Visualization: Ermao Li. Writing ± original draft: Shankun Zhao. Writing ± review & editing: Zhigang Zhao. 11 / 13 12 / 13 1

Identification of two immortalized cell lines, ECV304 and bEnd3, for in vitro permeability studies of blood-brain barrier

to mimic in vivo BBB tight barrier need to be carried out. Author Contributions Conceptualization: Shu Yang, Zhigang Zhao. Data curation: Shu Yang, Yue Tian, Jiping Huo. Investigation: Shu Yang ... , Bin Zhu. Methodology: Shu Yang, Shenghui Mei. Supervision: Anchen Guo, Zhigang Zhao. Writing ± original draft: Shu Yang, Hong Jin. Writing ± review & editing: Xu Cui, Anchen Guo. 8 / 10 10

Operative versus non-operative treatment in complex proximal humeral fractures: a meta-analysis of randomized controlled trials

Whether operative treatment for complex proximal humeral fractures (CPHFs) has a greater benefit over non-operative treatment remains controversial. There is no consensus on the optimal treatment in elderly patients with CPHFs. This updated meta-analysis of randomized controlled trials (RCTs) aims to investigate whether operative treatment is superior to non-operative treatment...

Aspirin promotes bone marrow mesenchymal stem cell-based calvarial bone regeneration in mini swine

Zhao 2 Songlin Wang 4 Yi Liu 1 0 Equal contributors 1 Laboratory of Tissue Regeneration and Immunology and Department of Periodontics, Beijing Key Laboratory of Tooth Regeneration and Function

Knockdown of PSCA induces EMT and decreases metastatic potentials of the human prostate cancer DU145 cells

. Acknowledgements This work was supported by the grants from National Natural Science Foundation of China (No. 81072112, No. 81372774, No. 81572537 for Zhigang Zhao), The Key Program of Natural Science Foundation of ... Guangdong Province (No. 2015A030311007 for Zhigang Zhao), and Yangcheng Scholar Project of Guangzhou Education Bureau (No. 12A014G for Zhigang Zhao). Competing interests The authors declare that they have no

Genetic dissection on rice grain shape by the two-dimensional image analysis in one japonica × indica population consisting of recombinant inbred lines

Key message This article used seven characters from the 2D image analysis to dissect the genetic architecture underlying rice grain shape in one japonica × indica population consisting of 215 recombinant inbred lines. Abstract Two-dimensional (2D) digital image analysis is efficient for investigating the rice grain shape characters in large genetic and breeding populations. In...

Comorbidity as an independent prognostic factor in elderly patients with peripheral T-cell lymphoma

Comorbidity as an independent prognostic factor in elderly patients with peripheral T-cell lymphoma Haifeng Zhao,1,* Tengteng Wang,1,* Yafei Wang,1 Yong Yu,1 Xiaofan Wang,1 Zhigang Zhao,1 Hongliang

Clinical Utility of the UPOINT Phenotype System in Chinese Males with Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS): A Prospective Study

Background Recent data showed that a six-domain UPOINT is a flexible and responsive new classification system that has the clinical applicability in CP/CPPS. However, the utility of UPOINT algorithm in men in China with CP/CPPS has not been comprehensively studied. For international validation and adoption, we evaluated this clinical phenotype system for a large cohort of Chinese...

The role of OsMSH4 in male and female gamete development in rice meiosis

Meiosis is essential for gametogenesis in sexual reproduction in rice (Oryza sativa L.). We identified a MutS-homolog (MSH) family gene OsMSH4 in a trisomic plant. Cytological analysis showed that developments of both pollen and embryo sacs in an Osmsh4 mutant were blocked due to defective chromosome pairing. Compared with the wild type, the Osmsh4 mutant displayed a significant...

Mitochondrial respiratory dysfunctions of blood mononuclear cells link with cardiac disturbance in patients with early-stage heart failure

, Chongqing Institute of Hypertension, Chongqing 400042, ChinaPeng Li, Bin Wang, Fang Sun, Yingsha Li, Qiang Li, Hongmei Lang, Zhigang Zhao, Peng Gao, Daoyan Liu & Zhiming ZhuDepartment of Cardiology, Institute ... ScholarSearch for Zhigang Zhao in:Nature Research journals • PubMed • Google ScholarSearch for Peng Gao in:Nature Research journals • PubMed • Google ScholarSearch for Yu Zhao in:Nature Research journals • PubMed

Cigarette Smoking Is Associated with a Lower Prevalence of Newly Diagnosed Diabetes Screened by OGTT than Non-Smoking in Chinese Men with Normal Weight

Different studies have produced conflicting results regarding the association between smoking and diabetes mellitus, and detailed analysis of this issue in Chinese males based on nationwide samples is lacking. We explored the association between cigarette smoking and newly-diagnosed diabetes mellitus (NDM) in Chinese males using a population-based case-control analysis; 16,286...

The Different Immunoregulatory Functions of Mesenchymal Stem Cells in Patients with Low-Risk or High-Risk Myelodysplastic Syndromes

Myelodysplastic syndrome (MDS) are a group of progressive, clonal, neoplastic bone marrow disorders characterized by hematopoietic stem cell dysregulation and abnormalities in the immune system. Mesenchymal stem cells (MSC) have gained further interests after the demonstration of an immunoregulatory role. Nevertheless, the immunoregulatory function of MDS bone marrow derived MSC...

Activation of TRPV1 channel by dietary capsaicin improves visceral fat remodeling through connexin43-mediated Ca2+ Influx

Liang Qianqian Sun Hao Yu Jian Zhong Yinxing Ni Jing Chen Zhigang Zhao Peng Gao Bin Wang Daoyan Liu Zhiming Zhu Zhencheng Yan 0 Equal contributors Center for Hypertension and Metabolic Diseases

The Different Immunoregulatory Functions on Dendritic Cells between Mesenchymal Stem Cells Derived from Bone Marrow of Patients with Low-Risk or High-Risk Myelodysplastic Syndromes

Myelodysplastic syndrome (MDS) is a group of progressive,clonal, neoplastic bone marrow disorders characterized by hematopoietic stem cell dysregulation and abnormalities in the immune system. Mesenchymal stem cells (MSC) appear to modulate the immune system at the very first step of the immune response through the inhibition of dendritic cells (DCs) differentiation and...

Transient Receptor Potential Vanilloid 1 Activation Enhances Gut Glucagon-Like Peptide-1 Secretion and Improves Glucose Homeostasis

Peijian Wang Zhencheng Yan Jian Zhong Jing Chen Yinxing Ni Li Li Liqun Ma Zhigang Zhao Daoyan Liu Zhiming Zhu Type 2 diabetes mellitus (T2DM) is rapidly prevailing as a serious global health problem

Serum Early Prostate Cancer Antigen (EPCA) Level and Its Association with Disease Progression in Prostate Cancer in a Chinese Population

Background Early prostate cancer antigen (EPCA) has been shown a prostate cancer (PCa)-associated nuclear matrix protein, however, its serum status and prognostic power in PCa are unknown. The goals of this study are to measure serum EPCA levels in a cohort of patients with PCa prior to the treatment, and to evaluate the clinical value of serum EPCA. Methods Pretreatment serum...

Association between Family History Risk Categories and Prevalence of Diabetes in Chinese Population

Aim To investigate the association between different family history risk categories and prevalence of diabetes in the Chinese population. Methods The family history of diabetes was obtained from each subject, and an oral glucose tolerance test was performed for measuring the fasting and postload glucose and insulin levels based on a national representative cross-sectional survey...

TRPV1 activation prevents nonalcoholic fatty liver through UCP2 upregulation in mice

Nonalcoholic fatty liver is characterized by the fatty deformation and lipid deposition of hepatic parenchymal cells that are associated with cardiometabolic diseases. In this study, we report the effect of capsaicin on its receptor, transient receptor potential vanilloid 1 (TRPV1) cation channel, in preventing fatty liver formation. Functional TRPV1 has been detected in...

Obesity-Related Genomic Loci Are Associated with Type 2 Diabetes in a Han Chinese Population

Background and Aims Obesity is a well-known risk factor for type 2 diabetes. Genome-wide association studies have identified a number of genetic loci associated with obesity. The aim of this study is to examine the contribution of obesity-related genomic loci to type 2 diabetes in a Chinese population. Methods We successfully genotyped 18 obesity-related single nucleotide...