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33 papers found.
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Recombinant Zika virus envelope protein elicited protective immunity against Zika virus in immunocompetent mice

Jin. Formal analysis: Huabin Liang. Funding acquisition: Xia Jin. Investigation: Huabin Liang, Ruoheng Yang, Zhihua Liu. Methodology: Huabin Liang, Haitao Liu. Project administration: Huabin Liang ... , Xia Jin. Resources: Xia Jin. Supervision: Xia Jin. Writing ± original draft: Huabin Liang, Ruoheng Yang, Zhihua Liu, Min Li. Writing ± review & editing: Huabin Liang, Min Li, Xia Jin. 15 / 18 16 / 18

LRRK2 enhances Nod1/2-mediated inflammatory cytokine production by promoting Rip2 phosphorylation

Zhihua Liu declare that they have no conflict of interest. All institutional and national guidelines for the ethical care and use of laboratory animals were strictly followed. Measurement of cytokines in

Alleviation of the effects of saline-alkaline stress on maize seedlings by regulation of active oxygen metabolism by Trichoderma asperellum

This study investigated the influence of Trichoderma asperellum on active oxygen production in maize seedlings under saline–alkaline stress conditions. Two maize cultivars were tested: ‘Jiangyu 417’ (‘JY417’), which can tolerate saline–alkaline stress; and, ‘Xianyu 335’ (‘XY335’), which is sensitive to saline–alkaline stress. The seedlings were grown on natural saline–alkaline...

Paneth cells: the hub for sensing and regulating intestinal flora

The complex interplay between symbiotic bacteria and host immunity plays a key role in shaping intestinal homeostasis and maintaining host health. Paneth cells, as one of the major producers of antimicrobial peptides in the intestine under steady-state conditions, play a vital role in regulating intestinal flora. Many studies on inflammatory bowel disease (IBD)-associated genes...

Bogdanov–Takens bifurcation in a predator–prey model

October Zhihua Liu Pierre Magal Dongmei Xiao In this paper, we investigate a class of predator-prey model with age structure and discuss whether the model can undergo Bogdanov-Takens bifurcation ... )x1x2 + O(|(x1, x2)|3). · x2 = μ1 + μ2x2 + x21 − x1x2 + O(|(x1, x2)|3), 6. Conclusion Acknowledgments Zhihua Liu School of Mathematical Sciences Beijing Normal University Beijing 100875, People’s

Climatic and Landscape Influences on Fire Regimes from 1984 to 2010 in the Western United States

An improved understanding of the relative influences of climatic and landscape controls on multiple fire regime components is needed to enhance our understanding of modern fire regimes and how they will respond to future environmental change. To address this need, we analyzed the spatio-temporal patterns of fire occurrence, size, and severity of large fires (> 405 ha) in the...

Prognosis and postoperative genital function of function-preservative surgery of pelvic autonomic nerve preservation for male rectal cancer patients

Background To retrospectively evaluate postoperative genital function, local recurrence rate and survival rate after total mesorectal excision (TME) combined with or without pelvic autonomic nerve preservation (PANP) in male patients with rectal cancer. Methods A total of 953 male patients with rectal cancer after TME (518 patients received TME combined with PANP [PANP group] and...

Awareness and knowledge about human papillomavirus vaccination and its acceptance in China: a meta-analysis of 58 observational studies

Background The human papillomavirus (HPV) vaccines have been widely introduced in immunization programs worldwide, however, it is not accepted in mainland China. We aimed to investigate the awareness and knowledge about HPV vaccines and explore the acceptability of vaccination among the Chinese population. Methods A meta-analysis was conducted across two English (PubMed, EMBASE...

NetCAD: a network analysis tool for coronary artery disease-associated PPI network

Summary: The systematic and unbiased charting of protein–protein interaction (PPI) networks relevant to health or diseases has become an important and burgeoning challenge in systems biology. Further, current reports have supported that good correlation exists between the topological properties and biological function of protein nodes in networks. Coronary artery disease (CAD...

MiR-214 increases the sensitivity of breast cancer cells to tamoxifen and fulvestrant through inhibition of autophagy

’and 5’-gcTCTAGAatggatgacaagtgggctagg-3’. PCR was performed with genomic DNA and digested by both Sac I and Xba I and cloned into a modified pGL3-control vector pISO provided by Dr. Zhihua Liu [ 26 ... genuine thankfulness to Dr. Robert Clarke (Georgetown University) for gift of MCF7/LCC9 cells and Dr. Zhihua Liu (Chinese Academy of Medical Sciences) for providing pISO vector. Submit your next manuscript

AGP: A Multimethods Web Server for Alignment-Free Genome Phylogeny

Phylogenetic analysis based on alignment method meets huge challenges when dealing with whole-genome sequences, for example, recombination, shuffling, and rearrangement of sequences. Thus, various alignment-free methods for phylogeny construction have been proposed. However, most of these methods have not been implemented as tools or web servers. Researchers cannot use these...

Identifying the Threshold of Dominant Controls on Fire Spread in a Boreal Forest Landscape of Northeast China

The relative importance of fuel, topography, and weather on fire spread varies at different spatial scales, but how the relative importance of these controls respond to changing spatial scales is poorly understood. We designed a “moving window” resampling technique that allowed us to quantify the relative importance of controls on fire spread at continuous spatial scales using...

Transcriptional Suppression of CYP2A13 Expression by Lipopolysaccharide in Cultured Human Lung Cells and the Lungs of a CYP2A13-Humanized Mouse Model

CYP2A13, a human P450 enzyme preferentially expressed in the respiratory tract, is highly efficient in the metabolic activation of tobacco-specific nitrosamines. The aim of this study was to test the hypothesis that inflammation suppresses CYP2A13 expression in the lung, thus explaining the large interindividual differences in CYP2A13 levels previously found in human lung biopsy...

Ischemia/Reperfusion-Induced MKP-3 Impairs Endothelial NO Formation via Inactivation of ERK1/2 Pathway

Board of New York (A2009001) granted to Zhihua Liu. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript 1 Institute of Medicinal

Effects of Common Polymorphism rs11614913 in Hsa-miR-196a2 on Lung Cancer Risk

to Zhihua Liu. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: The authors have declared that no

CGAP: a new comprehensive platform for the comparative analysis of chloroplast genomes

), China Medical Board of New York (A2009001), Program for New Century Excellent Talents in University (NCET-12-0074) granted to Zhihua Liu. 1. Margulis L : Symbiotic theory of the origin of eukaryotic

Differentiation-Associated Genes Regulated by c-Jun and Decreased in the Progression of Esophageal Squamous Cell Carcinoma

Zhihua Liu 0 Nikki Pui-yue Lee, The University of Hong Kong, Hong Kong 0 1 State Key Lab of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences , Beijing , China , 2

Knockout of MIMP protein in lactobacillus plantarum lost its regulation of intestinal permeability on NCM460 epithelial cells through the zonulin pathway

Background Previous studies indicated that the micro integral membrane protein located within the media place of the integral membrane protein of Lactobacillus plantarum CGMCC 1258 had protective effects against the intestinal epithelial injury. In our study, we mean to establish micro integral membrane protein -knockout Lactobacillus plantarum (LPKM) to investigate the change of...