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Architecture of SWI/SNF chromatin remodeling complex

Zhang. Na Yang and Rui-min Xu provided the nucleosome core particles (NCP). Zhihui Zhang reconstructed the 3D structures under stain of SWI/SNF-NCP assembly and the SWI/SNF deletion mutants. Xuejuan Wang ... reconstructed the 3D structure of SWI/SNF complex and analyzed data with Gang Cai and Zhihui Zhang. Jiyu Xin constructed the subunit deletion mutants and purified the mutant SWI/SNF complexes with Zhihui Zhang

Nrf2 antioxidant pathway suppresses Numb-mediated epithelial–mesenchymal transition during pulmonary fibrosis

Nrf2 knockout mice for our experiments. This work was supported by the National Natural Science Foundation of China (No. 81274172, 81473267 and 81503330). Author information Author notes Zhihui Zhang ...  & Panpan ZhangSchool of Pharmacy, Anhui Medical University, Hefei, Anhui, 230032, ChinaWencheng Zhou, Wenhui Cui & Xiaoting Mo AuthorsSearch for Zhihui Zhang in:Nature Research journals • PubMed • Google

lincRNA-Cox2 regulates NLRP3 inflammasome and autophagy mediated neuroinflammation

Immunology, Tianjin Medical University, Tianjin, 300070, ChinaZhenyi Xue, Zimu Zhang, Hongkun Liu, Wen Li, Xiangdong Guo, Zhihui Zhang, Ying Liu, Long Jia, Yan Li, Yinghui Ren, Lijuan Zhang, Qi Zhang, Yurong ... • Google Scholar Search for Xiangdong Guo in:Nature Research journals • PubMed • Google Scholar Search for Zhihui Zhang in:Nature Research journals • PubMed • Google Scholar Search for Ying Liu in:Nature

Effects of Mesenchymal Stem Cell-Derived Exosomes on Experimental Autoimmune Uveitis

, New York. Author information AffiliationsTianjin Medical University Eye Hospital, Eye Institute &School of Optometry and Ophthalmology, Tianjin, 300384, P.R. ChinaLingling Bai, Zhihui Zhang, Chang Su ... journals • PubMed • Google Scholar Search for Hongxing Wang in:Nature Research journals • PubMed • Google Scholar Search for Zhihui Zhang in:Nature Research journals • PubMed • Google Scholar Search for

Nrf2 inhibits epithelial-mesenchymal transition by suppressing snail expression during pulmonary fibrosis

ScholarSearch for Zhihui Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Delin Li in:Nature Research journals • PubMed • Google ScholarSearch for Liucheng Li in:Nature Research journals

TCGA Expedition: A Data Acquisition and Management System for TCGA Data

Background The Cancer Genome Atlas Project (TCGA) is a National Cancer Institute effort to profile at least 500 cases of 20 different tumor types using genomic platforms and to make these data, both raw and processed, available to all researchers. TCGA data are currently over 1.2 Petabyte in size and include whole genome sequence (WGS), whole exome sequence, methylation, RNA...

Hepatitis C Virus Genotype Diversity among Intravenous Drug Users in Yunnan Province, Southwestern China

Background Recently, high proportions (15.6%–98.7%) of intravenous drug users (IDUs) in China were found to be positive for hepatitis C virus (HCV). Yunnan Province is located in southwestern China and borders one of the world's most important opium-producing regions, thus it is an important drug trafficking route to other regions of China. Methodology/Principal Findings Here, we...

An intensity ratio of interlocking loops determines circadian period length

Circadian clocks allow organisms to orchestrate the daily rhythms in physiology and behaviors, and disruption of circadian rhythmicity can profoundly affect fitness. The mammalian circadian oscillator consists of a negative primary feedback loop and is associated with some ‘auxiliary’ loops. This raises the questions of how these interlocking loops coordinate to regulate the...

Duck Enteritis Virus Glycoprotein D and B DNA Vaccines Induce Immune Responses and Immunoprotection in Pekin Ducks

DNA vaccine is a promising strategy for protection against virus infection. However, little is known on the efficacy of vaccination with two plasmids for expressing the glycoprotein D (gD) and glycoprotein B (gB) of duck enteritis virus (DEV) in inducing immune response and immunoprotection against virulent virus infection in Pekin ducks. In this study, two eukaryotic expressing...

BMP9 Inhibits Proliferation and Metastasis of HER2-Positive SK-BR-3 Breast Cancer Cells through ERK1/2 and PI3K/AKT Pathways

Bone morphogenetic protein 9 (BMP9), a member of TGF-β superfamily, is reported to inhibit the growth and migration of prostate cancer, osteosarcoma and triple-negative MDA-MB-231 breast cancer cells. However, little is known about the effect of on the biological behaviors of HER2-positive SK-BR-3 breast cancer cells and the underlying mechanisms. This study aimed to investigate...

The influence of oxygen and nitrogen contamination on the densification behavior of cryomilled copper powders during spark plasma sintering

It has been found difficult to fully densify some mechanically milled pure metal powders by spark plasma sintering (SPS). In this study, the densification behavior of cryomilled, nanostructured (NS) Cu powders during SPS was related to changes to the chemistry of the powders. The results showed that the presence of very small amounts of O and N in the powders, which were...

Association of Human Papillomavirus Infection and Abnormal Anal Cytology among HIV-Infected MSM in Beijing, China

cytologist from Hospital of Cancer, Chinese Academy of Medical Sciences and Peking Union Medical College (Dr. Zhihui Zhang). Using the Bethesda system criteria for evaluation of cervical cytological results

Degassing Behavior of Nanostructured Al and Its Composites

The synthesis of bulk ultrafine-grained (UFG) and nanostructured Al via cryomilling can frequently require a degassing step prior to consolidation, partly due to the large surface area of the as-milled powders. The objective of this study is to investigate the effects associated with cryomilling with stearic acid additions (as a process-control agent) on the degassing behavior of...