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The autophagic degradation of Cav-1 contributes to PA-induced apoptosis and inflammation of astrocytes

Clinical Medicine, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, ChinaSheng-Dan Nie, Ling-Ran Ma & Xin Li AuthorsSearch for Zi Chen in:Nature

Correction: Comprehensive target capture/next-generation sequencing as a second-tier diagnostic approach for congenital muscular dystrophy in Taiwan

Xia Tian Chung-Yee Yuo Wan-Zi Chen Tsu-Min Kan Yi-Ning Su Ichizo Nishino Lee-Jun C. Wong Yuh-Jyh Jong In Table 1, the COL6A2 mutation in Patient 14 is listed incorrectly. The mutation should be: c

Problem/case-based learning with competition introduced in severe infection education: an exploratory study

Background Problem/case-based learning (PCBL) is one of the most commonly used educational methods in medical schools. Aim To further improve PCBL in clinical course of severe infection by introducing competition mode. Methods Two classes of medical students were divided into two groups by class-based simple randomization and were taught the course of severe infection by PCBL. A...

Multisymplectic method for the Camassa-Holm equation

The Camassa-Holm equation, a completely integrable evolution equation, contains rich geometric structures. For the existence of the bi-Hamiltonian structure and the so-called peaked wave solutions, considerable interest has been aroused in the last several decades. Focusing on local geometric properties of the peaked wave solutions for the Camassa-Holm equation, we propose the...

Comprehensive target capture/next-generation sequencing as a second-tier diagnostic approach for congenital muscular dystrophy in Taiwan

Purpose Congenital muscular dystrophy (CMD) is a heterogeneous disease entity. The detailed clinical manifestation and causative gene for each subgroup of CMD are quite variable. This study aims to analyze the phenotypes and genotypes of Taiwanese patients with CMD as the epidemiology of CMD varies among populations and has been scantly described in Asia. Methods A total of 48...

Carbon nanotube-based substrates promote cardiogenesis in brown adipose-derived stem cells via β1-integrin-dependent TGF-β1 signaling pathway

Carbon nanotube-based substrates promote cardiogenesis in brown adipose-derived stem cells via β1-integrin-dependent TGF-β1 signaling pathway Hongyu Sun,1,* Yongchao Mou,2,* Yi Li,3,* Xia Li,4,* Zi ... the statistical analysis. Fuzhou Tian, Hongyu Sun, Zi Chen, and Yongchao Mou cowrote the manuscript draft. All authors contributed toward data analysis, drafting and critically revising the paper and

The Prevalence of Drug-Resistant Tuberculosis in Mainland China: An Updated Systematic Review and Meta-Analysis

Background In recent years, drug resistant tuberculosis (DR-TB) particularly the emergence of multi-drug-resistant tuberculosis (MDR-TB) has become a major public health issue. The most recent study regarding the prevalence of drug-resistant tuberculosis in mainland China was a meta-analysis published in 2011, and the subjects from the included studies were mostly enrolled before...

A Riccati-Bernoulli sub-ODE method for nonlinear partial differential equations and its application

The Riccati-Bernoulli sub-ODE method is firstly proposed to construct exact traveling wave solutions, solitary wave solutions, and peaked wave solutions for nonlinear partial differential equations. A Bäcklund transformation of the Riccati-Bernoulli equation is given. By using a traveling wave transformation and the Riccati-Bernoulli equation, nonlinear partial differential...

Elevated MTSS1 expression associated with metastasis and poor prognosis of residual hepatitis B-related hepatocellular carcinoma

Background Hepatectomy generally offers the best chance of long-term survival for patients with hepatocellular carcinoma (HCC). Many studies have shown that hepatectomy accelerates tumor metastasis, but the mechanism remains unclear. Methods An orthotopic nude mice model with palliative HCC hepatectomy was performed in this study. Metastasis-related genes in tumor following...

Exact solutions and multi-symplectic structure of the generalized KdV-type equation

The homogeneous balance of undetermined coefficients method is proposed to obtain not only exact solutions but also multi-symplectic structure of some nonlinear partial differential equations. Bilinear equation, N-soliton solutions, traveling wave solutions and multi-symplectic structure are obtained by applying the proposed method to the KdV equation. Accordingly, the definition...

A novel method for fast identification of a machine tool selected point temperature rise based on an adaptive unscented Kalman filter

A novel method is presented for fast identification of a machine tool selected point temperature rise, based on an adaptive unscented Kalman filter. The major advantage of the method is its ability to predict the selected point temperature rise in a short period of measuring time, like 30 min, instead of 3 to 6 h in conventional temperature rise tests. A fast identification...

Diagnostic Value of Mutation-Specific Antibodies for Immunohistochemical Detection of Epidermal Growth Factor Receptor Mutations in Non-Small Cell Lung Cancer: A Meta-Analysis

arrived at consensus (Zi Chen and Hong-bing Liu). Inclusion criteria for the primary studies were as follows: (1) all samples were NSCLC, confirmed either histologically or cytologically; (2) must have used ... the best-quality one. Data extraction and quality assessment Two investigators (Zi Chen and Hong-bing Liu) extracted the following data from independently the selected studies: (1) year of publication

The Frequency and Clinical Implication of ROS1 and RET Rearrangements in Resected Stage IIIA-N2 Non-Small Cell Lung Cancer Patients

To evaluate the frequency and clinicopathological features of ROS1 and RET rearrangements in N2 node positive stage IIIA (IIIA-N2) non-small cell lung cancer (NSCLC) patients, we retrospectively screened 204 cases with a tissue microarray (TMA) panel by fluorescent in situ hybridization (FISH), and confirmed by direct sequencing and immunohistochemistry (IHC). The relationship...

P68 RNA helicase as a molecular target for cancer therapy

The DEAD-box family of RNA helicase is known to be required in virtually all cellular processes involving RNA, and p68 is a prototypic one of the family. Reports have indicated that in addition to ATPase and RNA helicase ability, p68 can also function as a co-activator for transcription factors such as estrogen receptor alpha, tumor suppressor p53 and beta-catenin. More than that...

SUMOhydro: A Novel Method for the Prediction of Sumoylation Sites Based on Hydrophobic Properties

Sumoylation is one of the most essential mechanisms of reversible protein post-translational modifications and is a crucial biochemical process in the regulation of a variety of important biological functions. Sumoylation is also closely involved in various human diseases. The accurate computational identification of sumoylation sites in protein sequences aids in experimental...

Knockdown of miR-214 Promotes Apoptosis and Inhibits Cell Proliferation in Nasopharyngeal Carcinoma

MicroRNA-214 (MiR-214) is aberrantly expressed in several human tumors such as ovarian cancer and breast cancer. However, the role of miR-214 in nasopharyngeal carcinoma (NPC) is still unknown. In this study, we report that miR-214 was overexpressed in NPC cell lines and tissues. Silencing of miR-214 by LNA-antimiR-214 in NPC cells resulted in promoting apoptosis and suppressing...

Effects of Temperament and Character Profiles on State and Trait Depression and Anxiety: A Prospective Study of a Japanese Youth Population

Japanese Youth Population Xi Lu,1,2 Zi Chen,3 Xiaoyi Cui,2 Masayo Uji,1 Wataru Miyazaki,2 Masako Oda,2 Toshiaki Nagata,4 Toshinori Kitamura,5,6 and Takahiko Katoh2 1Department of Clinical Behavioural

Prediction of Ubiquitination Sites by Using the Composition of k-Spaced Amino Acid Pairs

As one of the most important reversible protein post-translation modifications, ubiquitination has been reported to be involved in lots of biological processes and closely implicated with various diseases. To fully decipher the molecular mechanisms of ubiquitination-related biological processes, an initial but crucial step is the recognition of ubiquitylated substrates and the...

Orphan receptor TR3 participates in cisplatin-induced apoptosis via Chk2 phosphorylation to repress intestinal tumorigenesis

Cisplatin is a widely used antitumor agent that induces aggressive cancer cell death via triggering cellular proteins involved in apoptosis. Here, we demonstrate that cisplatin effectively induces orphan nuclear receptor TR3 phosphorylation by activating Chk2 kinase activity and promoting cross talk between these two proteins, thereby contributing to the repression of intestinal...