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Increasing prevalence, molecular characterization and antifungal drug susceptibility of serial Candida auris isolates in Kuwait

Omar Al-Musallam for technical assistance. Author Contributions Conceptualization: Ziauddin Khan, Suhail Ahmad, Noura Al-Sweih. Data curation: Suhail Ahmad, Leena Joseph, Wadha Alfouzan, Mohammad ... Asadzadeh. Formal analysis: Ziauddin Khan, Suhail Ahmad, Leena Joseph, Mohammad Asadzadeh. Funding acquisition: Ziauddin Khan. Investigation: Suhail Ahmad, Leena Joseph. Project administration: Ziauddin

Population structure and molecular genetic characterization of clinical Candida tropicalis isolates from a tertiary-care hospital in Kuwait reveal infections with unique strains

Conceptualization: Suhail Ahmad, Ziauddin Khan. Data curation: Khaled Al-Obaid, Mohammad Asadzadeh, Ziauddin Khan. 12 / 16 Formal analysis: Khaled Al-Obaid, Mohammad Asadzadeh, Suhail Ahmad, Ziauddin Khan. Funding ... acquisition: Suhail Ahmad, Ziauddin Khan. Investigation: Khaled Al-Obaid, Mohammad Asadzadeh. Methodology: Khaled Al-Obaid, Mohammad Asadzadeh. Project administration: Suhail Ahmad, Ziauddin Khan. Resources

Population structure and molecular genetic characterization of 5-flucytosine-susceptible and -resistant clinical Candida dubliniensis isolates from Kuwait

in S1 Table. Funding: This study was funded by the College of Graduate Studies and Research Sector, Kuwait University with grant award numbers YM10/11, GM01/05 and SRUL02/13 to Ziauddin Khan. The

Simple, Low-Cost Detection of Candida parapsilosis Complex Isolates and Molecular Fingerprinting of Candida orthopsilosis Strains in Kuwait by ITS Region Sequencing and Amplified Fragment Length Polymorphism Analysis

Candida parapsilosis has now emerged as the second or third most important cause of healthcare-associated Candida infections. Molecular studies have shown that phenotypically identified C. parapsilosis isolates represent a complex of three species, namely, C. parapsilosis, C. orthopsilosis and C. metapsilosis. Lodderomyces elongisporus is another species phenotypically closely...

Development of a Novel Inhalational Model of Invasive Pulmonary Aspergillosis in Rats and Comparative Evaluation of Three Biomarkers for Its Diagnosis

-Shaikh 0 Ziauddin Khan 0 Scott G. Filler, David Geffen School of Medicine at University of California Los Angeles, United States of America 0 Department of Microbiology, Faculty of Medicine, Kuwait

Isolation of cholesterol-dependent, multidrug-resistant Candida glabrata strains from blood cultures of a candidemia patient in Kuwait

Background Candida glabrata has emerged as an important human pathogen associated with systemic and mucosal infections. Here, we describe isolation of two cholesterol-dependent Candida glabrata strains from a candidemia patient which failed to grow on the media devoid of a cholesterol source. Methods Both the isolates were recovered from BACTEC Plus Aerobic/F blood culture...

Molecular identification and antifungal susceptibility profile of Aspergillus flavus isolates recovered from clinical specimens in Kuwait

1 Ziauddin Khan 0 1 0 Aspergillus species is being increasingly recognized [2-4]. Aspergillus flavus is the second most important species causing localized as well as systemic

Performance comparison of phenotypic and molecular methods for detection and differentiation of Candida albicans and Candida dubliniensis

Background Candida albicans is the most pathogenic Candida species but shares many phenotypic features with Candida dubliniensis and may, therefore, be misidentified in clinical microbiology laboratories. Candidemia cases due to C. dubliniensis are increasingly being reported in recent years. Accurate identification is warranted since mortality rates are highest for C. albicans...

Candida dubliniensis: An Appraisal of Its Clinical Significance as a Bloodstream Pathogen

A nine-year prospective study (2002–2010) on the prevalence of Candida dubliniensis among Candida bloodstream isolates is presented. The germ tube positive isolates were provisionally identified as C. dubliniensis by presence of fringed and rough colonies on sunflower seed agar. Subsequently, their identity was confirmed by Vitek2 Yeast identification system and/or by...

Chaetomium-like fungi causing opportunistic infections in humans: a possible role for extremotolerance

Members of the family Chaetomiaceae are ubiquitous ascosporulating fungi commonly, which reside in soil enriched with manure or cellulosic materials. Their role as human pathogens is largely ignored. However, the ability of some species to grow at high temperature enables them to play an important role as opportunistic pathogens. The family contains several genera and species...

Geographically Structured Populations of Cryptococcus neoformans Variety grubii in Asia Correlate with HIV Status and Show a Clonal Population Structure

Ferry Hagen Weihua Pan Sitali Simwami Matthew C. Fisher Retno Wahyuningsih Arunaloke Chakrabarti Anuradha Chowdhary Reiko Ikeda Saad J. Taj-Aldeen Ziauddin Khan Margaret Ip Darma Imran Ridhawati Sjam

Resistance of Asian Cryptococcus neoformans Serotype A Is Confined to Few Microsatellite Genotypes

-Aldeen Ziauddin Khan Darma Imran Ridhawati Sjam Pojana Sriburee Wanqing Liao Kunyaluk Chaicumpar Natnicha Ingviya Johan W. Mouton Ilse Curfs-Breuker Teun Boekhout Jacques F. Meis Corne H. W. Klaassen