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Routine Computer Tomography Imaging for the Detection of Recurrences in High-Risk Melanoma Patients

Background The use of routine CT imaging for surveillance in asymptomatic patients with cutaneous melanoma is controversial. We report our experience using a surveillance strategy that included CT imaging for a cohort of patients with high-risk melanoma. Methods A total of 466 patients with high-risk cutaneous melanoma enrolled in adjuvant immunotherapy trials were followed for ...

Postmastectomy Radiotherapy: An American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology Focused Guideline Update

Purpose A joint American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology panel convened to develop a focused update of the American Society of Clinical Oncology guideline concerning use of postmastectomy radiotherapy (PMRT). Methods A recent systematic literature review by Cancer Care Ontario provided the primary evidentiary ...

Surgical Downstaging in an Open-Label Phase II Trial of Denosumab in Patients with Giant Cell Tumor of Bone

Background Surgical resection with curative intent for giant cell tumor of bone (GCTB) may be associated with severe morbidity. This interim analysis evaluated reduction in surgical invasiveness after denosumab treatment in patients with resectable GCTB. Methods Patients with primary or recurrent GCTB, for whom the initially planned surgery was associated with functional compromise ...

Embedded Cervical Esophagogastrostomy: A Simple and Convenient Method Using a Circular Stapler After Esophagectomy for Esophageal Carcinomas

Background Cervical esophagogastrostomy is currently the most common method for esophageal reconstruction after esophagectomy. The advantages and disadvantages of hand-sewn, linear-stapled, or circular-stapled anastomoses have been subject to debate in recent years. We explored a new method of end-to-side anastomosis using a circular stapler that embeds the anastomosis and the ...

Re: Axillary Staging in the Neoadjuvant Setting

TO THE EDITORS: 0 0 Oded Olsha, MB , BS, and Moshe Carmon, MD Department of Surgery, Shaare Zedek Medical Center , Jerusalem, Israel - We commend Chung and Giuliano for their attempt to bring some

Commentary to “Chromogranin A: Biological Function and Clinical Utility in Neuroendocrine Tumor Disease”

To the Editors:We read with interest the study by Modlin et al., published online on March 9, 2010, and although overall we found it to be valid,1 we found an error. We refer to this assertion in the abstract: “Serum and plasma measurements are concordant.” This is not true because they differ markedly. Chromogranin A (CgA) measured in plasma appears to be far higher than in serum. ...

Fresh Surgical Specimens Yield Breast Stem/Progenitor Cells and Reveal Their Oncogenic Abnormalities

Background The process by which breast cancer stem cells arise is unknown. It may be that the benign stem cells in breast tissue are transformed into malignant stem cells through the acquisition of genetic abnormalities. In this study, we collected and compared benign and malignant breast stem/progenitor cells to determine whether specific genetic abnormalities occur in breast ...

Body Surface Area Predicts Plasma Oxaliplatin and Pharmacokinetic Advantage in Hyperthermic Intraoperative Intraperitoneal Chemotherapy

Background Hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) is used to treat peritoneal surface-spreading malignancies to maximize local drug concentrations while minimizing systemic effects. The pharmacokinetic advantage of HIPEC is defined as the intraperitoneal to intravascular ratio of drug concentrations. We hypothesized that body surface area (BSA) would ...

Intramammary Sentinel Lymph Nodes: What is the Clinical Significance?

Sentinel lymph node biopsy (SLNB) has been widely accepted and used to determine axillary lymph node status for the past decade.1,2 Consequently, SLNB has been a valuable method for determining patients’ treatment options, such as whether or not a complete axillary lymph node dissection (CALND) would be necessary for local control and correct staging of the breast cancer patient. ...