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Non-invasive measures of coronary microcirculation: Taking the long road to the clinic

Although coronary microvascular disease is now a well-recognized entity that is associated with significant morbidity and mortality, current non-invasive strategies cannot differentiate between coronary microvascular disease (CMD) and obstructive epicardial stenosis. While the evaluation of intramyocardial blood volume as a surrogate measure for microvascular health may have...

Safety and tolerability of intravenous regadenoson in healthy subjects: A randomized, repeat-dose, placebo-controlled study

Background Regadenoson is a selective A2A adenosine receptor agonist indicated for radionuclide myocardial perfusion imaging in patients unable to undergo adequate exercise stress. However, the safety, tolerability, and plasma concentrations associated with repeated doses have not previously been assessed. Method and Results Healthy males and females were randomized to receive...

Impact of time-of-flight on qualitative and quantitative analyses of myocardial perfusion PET studies using 13N-ammonia

Background The impact of time-of-flight (TOF) in myocardial perfusion 13N-ammonia positron emission tomography (PET) is unclear. Methods and Results Twenty consecutive subjects underwent rest and adenosine stress 13N-ammonia myocardial perfusion PET. Two sets of images were reconstructed using TOF-ordered subset expectation maximization (TOF-OSEM) and 3-dimensional row-action...

Regadenoson-induced bradycardia and hypotension: Possible mechanism and antidote

0 S. R. Underwood, DM, FRCP, FRCR, FESC, FACC, FASNC K. A. Latus, MSc E. Reyes, MD , PhD K. Standbridge, RN, MSc S. Walker, RN K. Wechalekar, MB , BS, DRM, DNB (Nuclear Medicine) Imperial College

A randomized, double-blind, placebo-controlled study assessing the safety and tolerability of regadenoson in subjects with asthma or chronic obstructive pulmonary disease

Bruce M. Prenner Stan Bukofzer MBBCh MMed (Int) Sarah Behm BS Kathleen Feaheny MS Bruce E. McNutt MD Background. Adenosine receptor stress agents for myocardial perfusion imaging (MPI) may cause

Development and evaluation of a new fully automatic motion detection and correction technique in cardiac SPECT imaging

Chuanyong Bai Jamshid Maddahi Joel Kindem Richard Conwell BS Michael Gurley BS Rex Old CNMT Background. In cardiac SPECT perfusion imaging, motion correction of the data is critical to the

Phantom evaluation of a cardiac SPECT/VCT system that uses a common set of solid-state detectors for both emission and transmission scans

Background We developed a cardiac SPECT system (X-ACT) with low dose volume CT transmission-based attenuation correction (AC). Three solid-state detectors are configured to form a triple-head system for emission scans and reconfigured to form a 69-cm field-of-view detector arc for transmission scans. A near mono-energetic transmission line source is produced from the collimated...

The relationship of myocardial contraction and electrical excitation—the correlation between scintigraphic phase image analysis and electrophysiologic mapping

Background Phase imaging derived from equilibrium radionuclide angiography presents the ventricular contraction sequence. It has been widely but only indirectly correlated with the sequence of electrical myocardial activation. Objectives We sought to determine the specific relationship between the sequence of phase progression and the sequence of myocardial activation...

Prospective multicenter evaluation of rapid, gated SPECT myocardial perfusion upright imaging

Jamshid Maddahi jmaddahi@mednet FACC Ricardo Mendez John J. Mahmarian Gregory Thomas Hetal Babla MS Chuanyong Bai Samia Arram BS Peter Maffetone CNMT Richard Conwell BS Background. A novel three