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MAM-E17 rat model impairments on a novel continuous performance task: effects of potential cognitive enhancing drugs

cm) modified to include a touch-sensitive monitor (Elo Touch Solutions, Inc., Milpitas, CA, USA; see Mar et al. 2013; Oomen et al. 2013) controlled through in-house software (Visual Basic 2010 ... antinociceptive agent acting vianeuronal nicotinic acetylcholine receptors: II. In vivo characterization . J Pharmacol Exp Ther 285 : 787 - 794 . doi: 10 .1002/(ISSN) 2052 - 1707 Bari A , Eagle DM , Mar AC et al

Co-Transcriptomes of Initial Interactions In Vitro between Streptococcus Pneumoniae and Human Pleural Mesothelial Cells

Streptococcus pneumoniae (Spn) is a major causative organism of empyema, an inflammatory condition occurring in the pleural sac. In this study, we used human and Spn cDNA microarrays to characterize the transcriptional responses occurring during initial contact between Spn and a human pleural mesothelial cell line (PMC) in vitro. Using stringent filtering criteria, 42 and 23 Spn ...

Trial-unique, delayed nonmatching-to-location (TUNL) touchscreen testing for mice: sensitivity to dorsal hippocampal dysfunction

(Bussey et al. 2011; Horner et al. 2013; Mar et al. 2013; Oomen et al. 2013). Advantages of the operant testing system include less aversive task procedures, minimal experimenter contact due to automation

Kernel Density Surface Modelling as a Means to Identify Significant Concentrations of Vulnerable Marine Ecosystem Indicators

and species composition . Mar Biol Res 8 : 842 - 854 . 7. Murillo FJ , Kenchington E , Gonzalez C , Sacau M ( 2010 ) The use of density analyses to delineate significant concentrations of Pennatulaceans ... ) Distribution of deepwater corals of the Flemish Cap, Flemish Pass, and the Grand Banks of Newfoundland (Northwest Atlantic Ocean): interaction with fishing activities . ICES J mar Sci 68 : 319 - 332 . 10

Factors associated with healthcare avoidance among transgender women in Argentina

Introduction Transgender (TG) women in many settings continue to contend with barriers to healthcare, including experiences of stigma and discrimination. Argentina has a universal health care system and laws designed to promote healthcare access among TG women. However, little is known about barriers to healthcare access among TG women in this setting. The aim of this study was to ...

Deep-sea sponge grounds enhance diversity and abundance of epibenthic megafauna in the Northwest Atlantic

Beazley, L. I., Kenchington E. L., Murillo, F. J., and Sacau, M. 2013. Deep-sea sponge grounds enhance diversity and abundance of epibenthic megafauna in the Northwest Atlantic. – ICES Journal of Marine Science, 70: . The influence of structure-forming deep-water sponge grounds on the composition, diversity, and abundance of the local epibenthic megafaunal community of the Flemish ...

BioBloom tools: fast, accurate and memory-efficient host species sequence screening using bloom filters

Large datasets can be screened for sequences from a specific organism, quickly and with low memory requirements, by a data structure that supports time- and memory-efficient set membership queries. Bloom filters offer such queries but require that false positives be controlled. We present BioBloom Tools, a Bloom filter-based sequence-screening tool that is faster than BWA, Bowtie 2 ...

Succinate-CoA ligase deficiency due to mutations in SUCLA2 and SUCLG1: phenotype and genotype correlations in 71 patients

Background The encephalomyopathic mtDNA depletion syndrome with methylmalonic aciduria is associated with deficiency of succinate-CoA ligase, caused by mutations in SUCLA2 or SUCLG1. We report here 25 new patients with succinate-CoA ligase deficiency, and review the clinical and molecular findings in these and 46 previously reported patients. Patients and results Of the 71 ...

Neuronal deletion of GSK3β increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2

Background In the adult central nervous system, axonal regeneration is abortive. Regulators of microtubule dynamics have emerged as attractive targets to promote axonal growth following injury as microtubule organization is pivotal for growth cone formation. In this study, we used conditioned neurons with high regenerative capacity to further dissect cytoskeletal mechanisms that ...

Multi-species, multi-transcription factor binding highlights conserved control of tissue-specific biological pathways

, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H

A quality assessment of genetic association studies supporting susceptibility and outcome in acute lung injury

Introduction Clinical observations and animal models provide evidence that the development of acute lung injury (ALI), a phenomenon of acute diffuse lung inflammation in critically ill patients, is influenced by genetic factors. Association studies are the main tool for exploring common genetic variations underlying ALI susceptibility and/or outcome. We aimed to assess the quality ...

Transposable elements in phytopathogenic Verticillium spp.: insights into genome evolution and inter- and intra-specific diversification

Background Verticillium dahliae (Vd) and Verticillium albo-atrum (Va) are cosmopolitan soil fungi causing very disruptive vascular diseases on a wide range of crop plants. To date, no sexual stage has been identified in either microorganism suggesting that somatic mutation is a major force in generating genetic diversity. Whole genome comparative analysis of the recently sequenced ...

The Chromosomal Passenger Complex Activates Polo Kinase at Centromeres

INCENP acts as a protein scaffold that integrates the functions of two crucial mitotic kinases, Aurora B and Polo, at centromeres of mitotic chromosomes.

Floating Ice-Algal Aggregates below Melting Arctic Sea Ice

. Mar Ecol Prog Ser 310 : 33 - 46 . doi:10.3354/meps310033. 14. Tamelander T , Reigstad M , Hop H , Ratkova T ( 2009 ) Ice algal assemblages and vertical export of organic matter from sea ice in the ... in benthic community oxygen demand: A response to an ice algal bloom in the Beaufort Sea , Canadian Arctic ? J Mar Syst 67 : 1 - 12 . doi:10.1016/j.jmarsys. 2006 .07.006. 16. Wassmann P , Reigstad M

Menopausal symptoms in women undergoing chemotherapy-induced and natural menopause: a prospective controlled study

Background: Women with breast cancer frequently undergo menopause following adjuvant chemotherapy. Here, we investigated whether they have more severe symptoms than women undergoing natural menopause. Patients and methods: Forty-one women who had undergone menopause as a result of chemotherapy and 57 healthy women who had undergone recent natural menopause were evaluated on two ...

Bayesian and maximum likelihood phylogenetic analyses of protein sequence data under relative branch-length differences and model violation

was responsible for high-performance computing, and generated the figures. MAR initiated and supervised the project, and wrote the manuscript. Additional material Additional File 1 Description of 21

The interval between Ins2 and Ascl2 is dispensable for imprinting centre function in the murine Beckwith–Wiedemann region

Imprinted genes are commonly clustered in domains across the mammalian genome, suggesting a degree of coregulation via long-range coordination of their monoallelic transcription. The distal end of mouse chromosome 7 (Chr 7) contains two clusters of imprinted genes within a ∼1 Mb domain. This region is conserved on human 11p15.5 where it is implicated in the Beckwith–Wiedemann ...

Transparent Development of the WHO Rapid Advice Guidelines

the Health Services , Oslo , Norway. Richard Bellamy is with the Department of Infection and Travel Medicine, James Cook University Hospital , Middlesbrough , United Kingdom. Chris Del Mar is on the

DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers


The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data

& Dara S. Manoach & Jean-Luc Martinot & Mar Matarin & Karen A. Mather & Manuel Mattheisen & Morten Mattingsdal & Andreas Meyer-Lindenberg & Colm McDonald & Andrew M. McIntosh & Francis J. McMahon & Katie L