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Identification and validation of uterine stimulant methylergometrine as a potential inhibitor of caspase-1 activation

Inflammasomes are intracellular multiprotein complexes of the innate immune system. Upon an inflammatory insult, such as infection or intracellular damage, a nucleotide-binding oligomerization domain-like receptor (NLR) sensor protein and the adaptor protein ASC (apoptosis-associated speck-like protein containing a caspase activation and recruitment domain) are assembled to ...

Team Creative Environment as a Mediator Between CWX and R&D Team Performance and Moderating Boundary Conditions

Purpose The purpose of this study was to investigate how high-quality dyadic co-worker relationships (CWXs) favour or hinder team performance. Specifically, we examine the role played by CWX, team creative environment, job complexity and task interdependence to achieve higher levels of team performance. Design/Methodology/Approach We analyse data from 410 individuals belonging to ...

Environmental factors influencing the spatio-temporal distribution of Carybdea marsupialis (Lineo, 1978, Cubozoa) in South-Western Mediterranean coasts

ValparaÂõso, ValparaÂõso, Chile, 2 Marine Biology and Oceanography Department, Institut de Ciències del Mar, Consejo Superior de Investigaciones CientÂõficas , Barcelona , Spain , 3 Dipartimento di Scienze ... ( 15 mm) individuals. The Spanish Ministry of the Environment (DireccioÂn General de Sostenibilidad de la Costa y el Mar) and the regional environmental authority (DireccioÂn General del Agua) supported

Leveraging workflow control patterns in the domain of clinical practice guidelines

Background Clinical practice guidelines (CPGs) include recommendations describing appropriate care for the management of patients with a specific clinical condition. A number of representation languages have been developed to support executable CPGs, with associated authoring/editing tools. Even with tool assistance, authoring of CPG models is a labor-intensive task. We aim at ...

Traffic-related air pollution and spectacles use in schoolchildren

, China, 9 IMIM-Parc Salut Mar , Spain - OPEN ACCESS Funding: The research leading to these results has received funding from the European Research Council under the ERC Grant Agreement number 268479 ... and the BREATHE project was approved (No. 2010/41221/I) by the Clinical Research Ethical Committee of the Parc de Salut MAR, Barcelona, Spain. Outcome and covariate data We considered the use of

Body image satisfaction and weight concerns among a Mediterranean adult population

Background People tend to underestimate their current weight and overestimate their height minimizing health risk factors. The aim of this study was to assess body weight satisfaction, acceptance of body image, weight concern and dieting habits among a Mediterranean adult population. Methods Cross-sectional survey was carried out (2009–2010) in the Balearic Islands, Spain. A random ...

Executive Functioning in Men with Schizophrenia and Substance Use Disorders. Influence of Lifetime Suicide Attempts

Background Lifetime suicide attempts in patients with comorbidity between psychotic disorders and Substance Use Disorder (SUD), known as dual diagnosis, was associated with a worse clinical and cognitive state, poor prognosis and premature death. However, to date no previous study has examined the cognitive performance of these patients considering as independent the presence or ...

Aspergillus sydowii and Other Potential Fungal Pathogens in Gorgonian Octocorals of the Ecuadorian Pacific

(Corallium rubrum L.) . Mar Biol . 2006 ; 149 : 1059 ± 1070 . doi: 10 .1007/s00227-006- 0302-8 6. Gates RD , Ainsworth TD . The nature and taxonomic composition of coral symbiomes as drivers of performance ... limits in scleractinian corals . J Exp Mar Bio Ecol . Elsevier B.V. ; 2011 ; 408 : 94 ± 101 . doi: 10 . 1016/j.jembe. 2011 . 07 .029 7. NystroÈm M , Folke C , Moberg F. Coral reef disturbance and

FLIPPED-TIC: Una experiencia de Flipped Classroom con alumnos de Magisterio / FLIPPED-TIC: A Flipped Classroom experience with preservice teachers

Flipped TIC es un proyecto de innovación docente que se desarrolló en la Facultad de Educación de la Universidad de Murcia (España). El principal objetivo de este proyecto ha sido la realización de una experiencia de Flipped Classroom en un aula universitaria. Tradicionalmente los alumnos reciben del docente en el aula una primera aproximación a los contenidos de la asignatura, ...

Preventing the Complications Associated with the Use of Dermal Fillers in Facial Aesthetic Procedures: An Expert Group Consensus Report

Background The use of dermal fillers in minimally invasive facial aesthetic procedures has become increasingly popular of late, yet as the indications and the number of procedures performed increase, the number of complications is also likely to increase. Paying special attention to specific patient characteristics and to the technique used can do much to avoid these complications. ...

Optical system for measuring the spectral retardance function in an extended range

Background Optical retarders are key elements for the control of the state of polarization of light, and their wavelength dependance is of great importance in a number of applications. Methods We apply a well-known technique for determinig the spectral retardance by measuring the transmission spectra between crossed or parallel polarizers. But we we develop an optical system to ...

Differences in gut microbiota profile between women with active lifestyle and sedentary women

Physical exercise is a tool to prevent and treat some of the chronic diseases affecting the world’s population. A mechanism through which exercise could exert beneficial effects in the body is by provoking alterations to the gut microbiota, an environmental factor that in recent years has been associated with numerous chronic diseases. Here we show that physical exercise performed ...

Dietary patterns are associated with lung function among Spanish smokers without respiratory disease

Background Diet can help preserve lung function in smokers, in addition to avoidance of smoking. The study aimed to evaluate associations between dietary patterns and lung function in smokers without respiratory disease. Methods This cross-sectional study analysed baseline data from randomised representative smokers without respiratory disease (n = 207, aged 35–70 years), selected ...

Impact of hyperkalaemia definition on incidence assessment: implications for epidemiological research based on a large cohort study in newly diagnosed heart failure patients in primary care

failure patients in primary care Mar Martín-Pérez Ana Ruigómez Alexander Michel Luis A. García Rodríguez Background: Various definitions of hyperkalaemia have been used in clinical research, and data

A conserved role of the RSC chromatin remodeler in the establishment of nucleosome-depleted regions

The occupancy of nucleosomes governs access to the eukaryotic genomes and results from a combination of biophysical features and the effect of ATP-dependent remodelling complexes. Most promoter regions show a conserved pattern characterized by a nucleosome-depleted region (NDR) flanked by nucleosomal arrays. The conserved RSC remodeler was reported to be critical to establish NDR ...

Diagnostic Accuracy of the Enhanced Liver Fibrosis (ELF®) Score Using HCV-Infected Serum Samples Cryopreserved for up to 25 Years

, Spain, 3 Laboratori de Referència de Catalunya, Barcelona , Spain , 4 Pathology Department, Hospital del Mar , Barcelona , Spain 2 Editor: Pavel Strnad , Medizinische Fakultat der RWTH Aachen , GERMANY

Adiposity markers and lung function in smokers: a cross-sectional study in a Mediterranean population

Background The aim of this study was to assess the association of key adiposity markers with lung function in smokers without respiratory disease in a Mediterranean population. Methods We performed a cross-sectional study with baseline data from a representative sample of the ESPITAP study in Spain. Participants were 738 smokers (52.3% men) without respiratory disease, aged 35 to ...

Bleeding Risk with Long-Term Low-Dose Aspirin: A Systematic Review of Observational Studies

Background Low-dose aspirin has proven effectiveness in secondary and primary prevention of cardiovascular events, but is also associated with an increased risk of major bleeding events. For primary prevention, this absolute risk must be carefully weighed against the benefits of aspirin; such assessments are currently limited by a lack of data from general populations. Methods ...

Impact of diabetes on the predictive value of heart failure biomarkers

Background Patients with diabetes mellitus (DM) have an increased risk of developing heart failure (HF). Further, DM is associated with poor prognosis in patients with HF. Our aim was to determine whether DM has any impact on the predictive value of a multi-biomarker panel in patients with HF. Methods We included 1069 consecutive ambulatory HF patients in the study: age 66.2 ± 12.8 ...

The Protein Kinase CK2 Mediates Cross-Talk between Auxin- and Salicylic Acid-Signaling Pathways in the Regulation of PINOID Transcription

. 2011 ; 356 : 233 - 40 . doi: 10 .1007/s11010- 011 -0970-7 PMID: 21739152 41. Moreno-Romero J , Armengot L , Mar Marquès-Bueno M , Britt A , Carmen Martínez M. CK2 -defective Arabidopsis plants exhibit