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Identification and validation of uterine stimulant methylergometrine as a potential inhibitor of caspase-1 activation

Inflammasomes are intracellular multiprotein complexes of the innate immune system. Upon an inflammatory insult, such as infection or intracellular damage, a nucleotide-binding oligomerization domain-like receptor (NLR) sensor protein and the adaptor protein ASC (apoptosis-associated speck-like protein containing a caspase activation and recruitment domain) are assembled to ...

Team Creative Environment as a Mediator Between CWX and R&D Team Performance and Moderating Boundary Conditions

Purpose The purpose of this study was to investigate how high-quality dyadic co-worker relationships (CWXs) favour or hinder team performance. Specifically, we examine the role played by CWX, team creative environment, job complexity and task interdependence to achieve higher levels of team performance. Design/Methodology/Approach We analyse data from 410 individuals belonging to ...

An optimization design proposal of automated guided vehicles for mixed type transportation in hospital environments

Aim The aim of this paper is to present an optimization proposal in the automated guided vehicles design used in hospital logistics, as well as to analyze the impact of its implementation in a real environment. Method This proposal is based on the design of those elements that would allow the vehicles to deliver an extra cart by the towing method. So, the proposal intention is to ...

Prediction of long-term outcomes of HIV-infected patients developing non-AIDS events using a multistate approach

13 / 16 Author Contributions Conceptualization: Mar MasiaÂ, Sergio Padilla, FeÂlix GutieÂrrez. Data curation: Mar MasiaÂ, Sergio Padilla, Santiago Moreno, Jose A. Iribarren, Jorge del Romero, Juan ... L. GoÂmez-Sirvent, MarÂõa Rivero, Francesc Vidal, Antonio A. Campins. Formal analysis: Mar MasiaÂ, Sergio Padilla, Xavier Barber, FeÂlix GutieÂrrez. Funding acquisition: Mar MasiaÂ, FeÂlix

Environmental factors influencing the spatio-temporal distribution of Carybdea marsupialis (Lineo, 1978, Cubozoa) in South-Western Mediterranean coasts

ValparaÂõso, ValparaÂõso, Chile, 2 Marine Biology and Oceanography Department, Institut de Ciències del Mar, Consejo Superior de Investigaciones CientÂõficas , Barcelona , Spain , 3 Dipartimento di Scienze ... ( 15 mm) individuals. The Spanish Ministry of the Environment (DireccioÂn General de Sostenibilidad de la Costa y el Mar) and the regional environmental authority (DireccioÂn General del Agua) supported

Procalcitonin for selecting the antibiotic regimen in outpatients with low-risk community-acquired pneumonia using a rapid point-of-care testing: A single-arm clinical trial

Objective We aimed to assess the role of procalcitonin (PCT) to guide the initial selection of the antibiotic regimen for low-risk community-acquired pneumonia (CAP). Methods A single-arm clinical trial was conducted including outpatients with CAP and Pneumonia Severity Index risk classes I-II. Antimicrobial selection was based on the results of PCT measured with a rapid ...

Unintentional weight loss: Clinical characteristics and outcomes in a prospective cohort of 2677 patients

Background Whereas there are numerous studies on unintentional weight loss (UWL), these have been limited by small sample sizes, short or variable follow‐up, and focus on older patients. Although some case series have revealed that malignancies escaping early detection and uncovered subsequently are exceptional, reported follow-ups have been too short or unspecified and necropsies ...

Controlled delivery of tauroursodeoxycholic acid from biodegradable microspheres slows retinal degeneration and vision loss in P23H rats

Successful drug therapies for treating ocular diseases require effective concentrations of neuroprotective compounds maintained over time at the site of action. The purpose of this work was to assess the efficacy of intravitreal controlled delivery of tauroursodeoxycholic acid (TUDCA) encapsulated in poly(D,L-lactic-co-glycolic acid) (PLGA) microspheres for the treatment of the ...

Leveraging workflow control patterns in the domain of clinical practice guidelines

Background Clinical practice guidelines (CPGs) include recommendations describing appropriate care for the management of patients with a specific clinical condition. A number of representation languages have been developed to support executable CPGs, with associated authoring/editing tools. Even with tool assistance, authoring of CPG models is a labor-intensive task. We aim at ...

Human metapnuemovirus infections in hospitalized children and comparison with other respiratory viruses. 2005-2014 prospective study

Background Human metapneumovirus (HMPV) has an important etiological role in acute lower respiratory infections in children under five years. Our objectives were to estimate the relative contribution of HMPV to hospitalization in children with acute respiratory infection, to define the clinical and epidemiological features of HMPV single and multiple infections, and to compare HMPV ...

Body image satisfaction and weight concerns among a Mediterranean adult population

Background People tend to underestimate their current weight and overestimate their height minimizing health risk factors. The aim of this study was to assess body weight satisfaction, acceptance of body image, weight concern and dieting habits among a Mediterranean adult population. Methods Cross-sectional survey was carried out (2009–2010) in the Balearic Islands, Spain. A random ...

Traffic-related air pollution and spectacles use in schoolchildren

, China, 9 IMIM-Parc Salut Mar , Spain - OPEN ACCESS Funding: The research leading to these results has received funding from the European Research Council under the ERC Grant Agreement number 268479 ... and the BREATHE project was approved (No. 2010/41221/I) by the Clinical Research Ethical Committee of the Parc de Salut MAR, Barcelona, Spain. Outcome and covariate data We considered the use of

Aspergillus sydowii and Other Potential Fungal Pathogens in Gorgonian Octocorals of the Ecuadorian Pacific

(Corallium rubrum L.) . Mar Biol . 2006 ; 149 : 1059 ± 1070 . doi: 10 .1007/s00227-006- 0302-8 6. Gates RD , Ainsworth TD . The nature and taxonomic composition of coral symbiomes as drivers of performance ... limits in scleractinian corals . J Exp Mar Bio Ecol . Elsevier B.V. ; 2011 ; 408 : 94 ± 101 . doi: 10 . 1016/j.jembe. 2011 . 07 .029 7. NystroÈm M , Folke C , Moberg F. Coral reef disturbance and

FLIPPED-TIC: Una experiencia de Flipped Classroom con alumnos de Magisterio / FLIPPED-TIC: A Flipped Classroom experience with preservice teachers

Flipped TIC es un proyecto de innovación docente que se desarrolló en la Facultad de Educación de la Universidad de Murcia (España). El principal objetivo de este proyecto ha sido la realización de una experiencia de Flipped Classroom en un aula universitaria. Tradicionalmente los alumnos reciben del docente en el aula una primera aproximación a los contenidos de la asignatura, ...

Executive Functioning in Men with Schizophrenia and Substance Use Disorders. Influence of Lifetime Suicide Attempts

Background Lifetime suicide attempts in patients with comorbidity between psychotic disorders and Substance Use Disorder (SUD), known as dual diagnosis, was associated with a worse clinical and cognitive state, poor prognosis and premature death. However, to date no previous study has examined the cognitive performance of these patients considering as independent the presence or ...

Optical system for measuring the spectral retardance function in an extended range

Background Optical retarders are key elements for the control of the state of polarization of light, and their wavelength dependance is of great importance in a number of applications. Methods We apply a well-known technique for determinig the spectral retardance by measuring the transmission spectra between crossed or parallel polarizers. But we we develop an optical system to ...

Preclinical Immunomodulation by the Probiotic Bifidobacterium breve M-16V in Early Life

This study aimed to investigate the effect of supplementation with the probiotic Bifidobacterium breve M-16V on the maturation of the intestinal and circulating immune system during suckling. In order to achieve this purpose, neonatal Lewis rats were supplemented with the probiotic strain from the 6th to the 18th day of life. The animals were weighed during the study, and faecal ...

Preventing the Complications Associated with the Use of Dermal Fillers in Facial Aesthetic Procedures: An Expert Group Consensus Report

Background The use of dermal fillers in minimally invasive facial aesthetic procedures has become increasingly popular of late, yet as the indications and the number of procedures performed increase, the number of complications is also likely to increase. Paying special attention to specific patient characteristics and to the technique used can do much to avoid these complications. ...

Differences in gut microbiota profile between women with active lifestyle and sedentary women

Physical exercise is a tool to prevent and treat some of the chronic diseases affecting the world’s population. A mechanism through which exercise could exert beneficial effects in the body is by provoking alterations to the gut microbiota, an environmental factor that in recent years has been associated with numerous chronic diseases. Here we show that physical exercise performed ...

Dietary patterns are associated with lung function among Spanish smokers without respiratory disease

Background Diet can help preserve lung function in smokers, in addition to avoidance of smoking. The study aimed to evaluate associations between dietary patterns and lung function in smokers without respiratory disease. Methods This cross-sectional study analysed baseline data from randomised representative smokers without respiratory disease (n = 207, aged 35–70 years), selected ...