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MAM-E17 rat model impairments on a novel continuous performance task: effects of potential cognitive enhancing drugs

cm) modified to include a touch-sensitive monitor (Elo Touch Solutions, Inc., Milpitas, CA, USA; see Mar et al. 2013; Oomen et al. 2013) controlled through in-house software (Visual Basic 2010 ... antinociceptive agent acting vianeuronal nicotinic acetylcholine receptors: II. In vivo characterization . J Pharmacol Exp Ther 285 : 787 - 794 . doi: 10 .1002/(ISSN) 2052 - 1707 Bari A , Eagle DM , Mar AC et al

Ethnicity and the first diagnosis of a wide range of cardiovascular diseases: Associations in a linked electronic health record cohort of 1 million patients

Background While the association of ethnic group with individual cardiovascular diseases has been studied, little is known about ethnic differences in the initial lifetime presentation of clinical cardiovascular disease in contemporary populations. Methods and results We studied 1,068,318 people, aged ≥30 years and free from diagnosed CVD at baseline (90.9% White, 3.6% South Asian ...

PREditOR: a synthetic biology approach to removing heterochromatin from cells

It is widely accepted that heterochromatin is necessary to maintain genomic stability. However, direct experimental evidence supporting this is slim. Previous studies using either enzyme inhibitors, gene knockout or knockdown studies all are subject to the caveat that drugs may have off-target effects and enzymes that modify chromatin proteins to support heterochromatin formation ...

PREditOR: a synthetic biology approach to removing heterochromatin from cells

It is widely accepted that heterochromatin is necessary to maintain genomic stability. However, direct experimental evidence supporting this is slim. Previous studies using either enzyme inhibitors, gene knockout or knockdown studies all are subject to the caveat that drugs may have off-target effects and enzymes that modify chromatin proteins to support heterochromatin formation ...

Impact of hyperkalaemia definition on incidence assessment: implications for epidemiological research based on a large cohort study in newly diagnosed heart failure patients in primary care

failure patients in primary care Mar Martín-Pérez Ana Ruigómez Alexander Michel Luis A. García Rodríguez Background: Various definitions of hyperkalaemia have been used in clinical research, and data

Bleeding Risk with Long-Term Low-Dose Aspirin: A Systematic Review of Observational Studies

Background Low-dose aspirin has proven effectiveness in secondary and primary prevention of cardiovascular events, but is also associated with an increased risk of major bleeding events. For primary prevention, this absolute risk must be carefully weighed against the benefits of aspirin; such assessments are currently limited by a lack of data from general populations. Methods ...

Educational interventions to improve people’s understanding of key concepts in assessing the effects of health interventions: a systematic review protocol

study . Integr Cancer Ther . 2007 ; 6 : 345 - 53 . doi: 10 .1177/1534735407309482. 17. Hoffmann TC , Del Mar C. Patients' expectations of the benefits and harms of treatments, screening, and tests . JAMA

The geographical distribution and prevalence of Echinococcus multilocularis in animals in the European Union and adjacent countries: a systematic review and meta-analysis

Background This study aimed to provide a systematic review on the geographical distribution of Echinococcus multilocularis in definitive and intermediate hosts in the European Union (EU) and adjacent countries (AC). The relative importance of the different host species in the life-cycle of this parasite was highlighted and gaps in our knowledge regarding these hosts were ...

Rheumatoid Arthritis and Incidence of Twelve Initial Presentations of Cardiovascular Disease: A Population Record-Linkage Cohort Study in England

Introduction While rheumatoid arthritis is an established risk factor for cardiovascular disease (CVD), our knowledge of how the pattern of risk varies for different cardiovascular phenotypes is incomplete. The association between rheumatoid arthritis and the initial presentation of 12 types of CVDs were examined in a contemporary population of men and women of a wide age range. ...

Difference in Restricted Mean Survival Time for Cost-Effectiveness Analysis Using Individual Patient Data Meta-Analysis: Evidence from a Case Study

Hills, Cardiff University , UNITED KINGDOM - OPEN ACCESS Data Availability Statement: Data were used with permission obtained from the MAR-LC Collaborative Group investigators, who agreed to share ... patient-level data from the Meta-Analysis of Radiotherapy in Lung Cancer (MAR-LC) collaborative group [ 19 ] which was previously used in a Dutch economic evaluation [ 20 ]. The MAR-LC comprised 2,000

Reproductive cessation and post-reproductive lifespan in Asian elephants and pre-industrial humans

, Mason G : A review of the welfare of zoo elephants in Europe . Horsham, UK: RSPCA; 2002 : 203 - 205 . 27. Clubb R , Rowcliffe M , Lee P , Mar KU , Moss C , Mason GJ : Compromised survivorship in zoo ... . Hayward AD , Mar KU , Lahdenper M , Lummaa V : Early reproductive investment, senescence and lifetime reproductive success in female Asian elephants . J Evol Biol 2014 , 27 ( 4 ): 772 - 783 . 39. Mar KU

Microenvironmental Heterogeneity Parallels Breast Cancer Progression: A Histology–Genomic Integration Analysis

Background The intra-tumor diversity of cancer cells is under intense investigation; however, little is known about the heterogeneity of the tumor microenvironment that is key to cancer progression and evolution. We aimed to assess the degree of microenvironmental heterogeneity in breast cancer and correlate this with genomic and clinical parameters. Methods and Findings We ...

Depression as a Risk Factor for the Initial Presentation of Twelve Cardiac, Cerebrovascular, and Peripheral Arterial Diseases: Data Linkage Study of 1.9 Million Women and Men

Background Depression is associated with coronary heart disease and stroke, but associations with a range of pathologically diverse cardiovascular diseases are not well understood. We examine the risk of 12 cardiovascular diseases according to depression status (history or new onset). Methods Cohort study of 1,937,360 adult men and women, free from cardiovascular disease at ...

The effects of an Audio Visual Assisted Therapy Aid for Refractory auditory hallucinations (AVATAR therapy): study protocol for a randomised controlled trial

Background Psychological interventions which adopt an explicitly interpersonal approach are a recent development in the treatment of distressing voices. AVATAR therapy is one such approach which creates a direct dialogue between a voice-hearer and a computerised representation of their persecutory voice (the avatar) through which the person may be supported to gain a sense of ...

Co-Transcriptomes of Initial Interactions In Vitro between Streptococcus Pneumoniae and Human Pleural Mesothelial Cells

Streptococcus pneumoniae (Spn) is a major causative organism of empyema, an inflammatory condition occurring in the pleural sac. In this study, we used human and Spn cDNA microarrays to characterize the transcriptional responses occurring during initial contact between Spn and a human pleural mesothelial cell line (PMC) in vitro. Using stringent filtering criteria, 42 and 23 Spn ...

How Big Is It Really? Assessing the Efficacy of Indirect Estimates of Body Size in Asian Elephants

/j.biocon. 2008 . 05 .007 10. Jaquet N. A simple photogrammetric technique to measure sperm whales at sea . Mar Mammal Sci . 2006 ; 22 : 862 - 879 . doi: 10 .1111/j.1748- 7692 . 2006 . 00060 .x 11. Lindstedt ... technique for measuring Hector's dolphins (Cephalorhynchus hectori) in the field . Mar Mammal Sci . 2010 ; 26 : 296 - 308 . doi: 10 .1111/j. 1748- 7692 . 2009 . 00326 .x 21. Jeffreys GL , Rowat D , Marshall H

Distinguishing between determinate and indeterminate growth in a long-lived mammal

ghorensis can inform their conservation management . Aquat Conserv Mar Freshw Ecosyst . 2015 ; 25 : 61 - 70 . 26. Arlinghaus R , Matsumura S , Dieckmann U. The conservation and fishery benefits of protecting ... a monogamous and monomorphic mammal: The case of Alpine marmots . Oecologia . 2013 ; 172 : 427 - 36 . 36. Hayward AD , Mar KU , Lahdenperä M , Lummaa V. Early reproductive investment, senescence and

Regulation of constitutive and alternative mRNA splicing across the human transcriptome by PRPF8 is determined by 5′ splice site strength

Research Council Cancer Unit, University of Cambridge , Cambridge Biomedical Campus, Box 197, Cambridge CB2 0XZ , UK 1 Vihandha O. Wickramasinghe and Mar Gonzàlez-Porta are joint first authors. John C

Epigenetics override pro-inflammatory PTGS transcriptomic signature towards selective hyperactivation of PGE2 in colorectal cancer

Background Misregulation of the PTGS (prostaglandin endoperoxide synthase, also known as cyclooxygenase or COX) pathway may lead to the accumulation of pro-inflammatory signals, which constitutes a hallmark of cancer. To get insight into the role of this signaling pathway in colorectal cancer (CRC), we have characterized the transcriptional and epigenetic landscapes of the PTGS ...