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22 papers found.
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BMP type II receptor as a therapeutic target in pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is a chronic disease characterized by a progressive elevation in mean pulmonary arterial pressure. This occurs due to abnormal remodeling of small peripheral lung vasculature resulting in progressive occlusion of the artery lumen that eventually causes right heart failure and death. The most common cause of PAH is inactivating mutations in the ...

Economic evaluation of the breast cancer screening programme in the Basque Country: retrospective cost-effectiveness and budget impact analysis

Government , Alameda Rekalde 39, 48008 Bilbao, Bizkaia , Spain 5 Evaluation and Epidemiology Department, Hospital del Mar - IMIM (Hospital del Mar Medical Research Institute) , Passeig Maritim 25-29, 08003 ... . Arrospide A , Rue M , van Ravesteyn NT , Comas M , Larrañaga N , Sarriugarte G , Mar J . Evaluation of health benefits and harms of the breast cancer screening programme in the Basque Country . BMC Cancer

The geographical distribution and prevalence of Echinococcus multilocularis in animals in the European Union and adjacent countries: a systematic review and meta-analysis

Background This study aimed to provide a systematic review on the geographical distribution of Echinococcus multilocularis in definitive and intermediate hosts in the European Union (EU) and adjacent countries (AC). The relative importance of the different host species in the life-cycle of this parasite was highlighted and gaps in our knowledge regarding these hosts were ...

Evaluation of health benefits and harms of the breast cancer screening programme in the Basque Country using discrete event simulation

. The Gothenburg Breast Screening Trial. Cancer . 2003 ; 97 : 2387 - 96 . 5. Arrospide A , Forne C , Rue M , Tora N , Mar J , Bare M. An assessment of existing models for individualized breast cancer risk ... Protection (ed). Luxembourg: Office for Official Publications of the European Communities; 2006 . 14. Comas M , Arrospide A , Mar J , Sala M , Vilaprinyo E , Hernandez C , et al. Budget impact analysis of

What is the effect of a formalised trauma tertiary survey procedure on missed injury rates in multi-trauma patients? Study protocol for a randomised controlled trial

; 39 : 107 - 14 . 2. Keijzers GB , Giannakopolous GF , Del Mar C , Bakker FC , Geeraedts Jr LM . The effect of tertiary surveys on missed injuries in trauma: a systematic review . Scand J Trauma Resusc

Trial-unique, delayed nonmatching-to-location (TUNL) touchscreen testing for mice: sensitivity to dorsal hippocampal dysfunction

(Bussey et al. 2011; Horner et al. 2013; Mar et al. 2013; Oomen et al. 2013). Advantages of the operant testing system include less aversive task procedures, minimal experimenter contact due to automation

The Small GTPase RhoB Regulates TNFα Signaling in Endothelial Cells

. Elias 0 Mar Fernandez-Borja 0 Venuprasad K. Poojary, Baylor Institute for Immunology Research, United States of America 0 Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory

Succinate-CoA ligase deficiency due to mutations in SUCLA2 and SUCLG1: phenotype and genotype correlations in 71 patients

Background The encephalomyopathic mtDNA depletion syndrome with methylmalonic aciduria is associated with deficiency of succinate-CoA ligase, caused by mutations in SUCLA2 or SUCLG1. We report here 25 new patients with succinate-CoA ligase deficiency, and review the clinical and molecular findings in these and 46 previously reported patients. Patients and results Of the 71 ...

The effect of tertiary surveys on missed injuries in trauma: a systematic review

Background Trauma tertiary surveys (TTS) are advocated to reduce the rate of missed injuries in hospitalized trauma patients. Moreover, the missed injury rate can be a quality indicator of trauma care performance. Current variation of the definition of missed injury restricts interpretation of the effect of the TTS and limits the use of missed injury for benchmarking. Only a few ...

A Prospective Evaluation of Missed Injuries in Trauma Patients, Before and After Formalising the Trauma Tertiary Survey

Objective This study prospectively evaluated in-hospital and postdischarge missed injury rates in admitted trauma patients, before and after the formalisation of a trauma tertiary survey (TTS) procedure. Methods Prospective before-and-after cohort study. TTS were formalised in a single regional level II trauma hospital in November 2009. All multitrauma patients admitted between ...

The Human Minor Histocompatibility Antigen1 Is a RhoGAP

Tol Mar Fernandez-Borja Dirk Geerts Jos Pool Lothar Hambach Els Goulmy Peter L. Hordijk Steen Henning Hansen, Children's Hospital Boston, United States of America The human minor Histocompatibility

Sphingosine-1-Phosphate Receptor 3 Mediates Sphingosine-1-Phosphate Induced Release of Weibel-Palade Bodies from Endothelial Cells

Sphingosine-1-phosphate (S1P) is an agonist for five distinct G-protein coupled receptors, that is released by platelets, mast cells, erythrocytes and endothelial cells. S1P promotes endothelial cell barrier function and induces release of endothelial cell-specific storage-organelles designated Weibel-Palade bodies (WPBs). S1P-mediated enhancement of endothelial cell barrier ...

The Shear Stress-Induced Transcription Factor KLF2 Affects Dynamics and Angiopoietin-2 Content of Weibel-Palade Bodies

Background The shear-stress induced transcription factor KLF2 has been shown to induce an atheroprotective phenotype in endothelial cells (EC) that are exposed to prolonged laminar shear. In this study we characterized the effect of the shear stress-induced transcription factor KLF2 on regulation and composition of Weibel-Palade bodies (WPBs) using peripheral blood derived ECs. ...

Combined impact of healthy lifestyle factors on colorectal cancer: a large European cohort study

Background Excess body weight, physical activity, smoking, alcohol consumption and certain dietary factors are individually related to colorectal cancer (CRC) risk; however, little is known about their joint effects. The aim of this study was to develop a healthy lifestyle index (HLI) composed of five potentially modifiable lifestyle factors � healthy weight, physical activity, ...

DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

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