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Clarifying the biological and statistical assumptions of cross-sectional biological age predictors: an elaborate illustration using synthetic and real data

There is divergence in the rate at which people age. The concept of biological age is postulated to capture this variability, and hence to better represent an individual’s true global physiological state than chronological age. Biological age predictors are often generated based on cross-sectional data, using biochemical or molecular markers as predictor variables. It is assumed...

Increasing number of long-lived ancestors marks a decade of healthspan extension and healthier metabolomics profiles

Beekman 4 , Mar Rodríguez-Girondo Check for updates Niels van den Berg Globally, the lifespan of populations increases but the healthspan is lagging behind. Previous research showed that survival into

The socio-ecological resilience and sustainability implications of seafood supply chain disruption

adaptations in Asia and Africa's aquatic food value chains . Mar Policy 129 : 104523 . https://doi.org/10.1016/j.marpol. 2021 .104523 Bennett NJ , Finkbeiner EM , Ban NC , Belhabib D , Jupiter SD , Kittinger JN ... , Buchary EA , Allison EH ( 2016 ) Towards a typology of interactions between small-scale fisheries and global seafood trade . Mar Policy 65 : 1 - 10 . https://doi.org/10.1016/j.marpol. 2015 . 11 . 016 Davis

Tacrolimus versus mycophenolate for AutoImmune hepatitis patients with incompLete response On first-line therapy (TAILOR study): a study protocol for a phase III, open-label, multicentre, randomised controlled trial

Autoimmune hepatitis (AIH) is a rare, chronic inflammatory disease of the liver. The treatment goal is reaching complete biochemical response (CR), defined as the normalisation of aspartate and alanine aminotransferases and immunoglobulin gamma. Ongoing AIH activity can lead to fibrosis and (decompensated) cirrhosis. Incomplete biochemical response is the most important risk...

Stigma Associated with Alcohol and Other Drug Use Among People from Migrant and Ethnic Minority Groups: Results from a Systematic Review of Qualitative Studies

Stigma reduces access to alcohol and other drug (AOD) support. This systematic review explored perceptions and experiences of stigma associated with AOD use among migrant and ethnic minority groups. Qualitative studies published in English were identified using six databases. Two reviewers screened and critically appraised articles using the Joanna Briggs Institute Critical...

The impact of gender and the social determinants of health on the clinical course of people living with HIV in Myanmar: an observational study

There is a growing recognition of the impact of gender and the social determinants of health on the clinical course of people living with HIV (PLHIV). However, the relative contribution of these factors to clinical outcomes of PLHIV is incompletely defined in many countries. This study was performed to gain a greater understanding of the non-clinical determinants of prognosis of...

Deconstructing heterogeneity of replicative senescence in human mesenchymal stem cells at single cell resolution

. Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics . BMC Genomics . 2018 ; 19 ( 1 ): 477 . 39. Dharmaratne M , A.S.K.A.T.F.J.C. Mar. scShapes: a statistical framework for

Investigating transcriptome-wide sex dimorphism by multi-level analysis of single-cell RNA sequencing data in ten mouse cell types

. Mar 0 0 Australian Institute for Bioengineering and Nanotechnology, The University of Queensland , Brisbane, QLD 4072 , Australia 1 Quantitative Life Sciences Program, McGill University , Montreal, QC ... . 2014 ; 32 ( 4 ): 381 - 6 . 11. Mar JC. The rise of the distributions: why non-normality is important for understanding the transcriptome and beyond . Biophys Rev . 2019 ; 11 ( 1 ): 89 - 94 . 12. Kim J

‘What happens if I do nothing?’ A Systematic Review of the Inclusion and Quantitative Description of a ‘No Active Intervention’ Option in Patient Decision Aids

decision-making. Tammy Hoffmann, PhD 1 Julia Beckhaus, BA 1 Chris Del Mar, MD 1 Conflict of Interest: None of the authors have any relevant conflicts of interest to declare. Open Access This article is ... . Hoffmann T , Del Mar C. Patients' expectations of the benefits and harms of treatments, screening, and tests: a systematic review . JAMA Intern Med . 2015 ; 175 : 274 - 86 . 2. Hoffmann T , Del Mar C

Study protocol for a randomised controlled trial to evaluate the use of melanoma surveillance photography to the Improve early detection of MelanomA in ultra-hiGh and high-risk patiEnts (the IMAGE trial)

proportion of missing data and likely mechanism of missingness (missing not at random (MNAR), missing at random (MAR)) [ 17 ]. Multiple imputation methods may be used if healthcare use data or AQOL-8D data ... are MAR, using a method considered most appropriate at time of analysis. Potential sources of bias We anticipate that participants in the control arm, who are not coming back to sites for imaging and

Bone mineral density among virologically suppressed Asians older than 50 years old living with and without HIV: A cross-sectional study

Sunthornyothin, Hay Mar Su Lwin, Sivaporn Gatechompol, Win Min Han, Thanathip Wichiansan, Tawatchai Chaiwatanarat, Anchalee Avihingsanon. Methodology: Lalita Wattanachanya, Anchalee Avihingsanon. Validation ... : Lalita Wattanachanya, Anchalee Avihingsanon. Writing – original draft: Lalita Wattanachanya. Writing – review & editing: Lalita Wattanachanya, Sarat Sunthornyothin, Hay Mar Su Lwin, Sivaporn Gatechompol

An alternative approach to estimate any subdaily extreme of rainfall and wind from usually available records

A wide variety of engineering applications requires the use of maximum values of rainfall intensity and wind speed related to short recording intervals, which can often only be estimated from available less exhaustive records. Given that many locations lack exhaustive climatic records that would allow accurate empirical correlations between different recording intervals to be...

Impact of 2018 EU Risk Minimisation Measures and Revised Pregnancy Prevention Programme on Utilisation and Prescribing Trends of Medicinal Products Containing Valproate: An Interrupted Time Series Study

Due to established teratogenicity of valproates, the EU risk minimisation measures (RMMs) with a pregnancy prevention programme (PPP) for valproate were updated in March 2018. To investigate the effectiveness of the 2018 EU RMMs on valproate utilisation in five European countries/regions. A multi-database, times series study of females of childbearing potential (12–55 years) was...

The impact of monosomies, trisomies and segmental aneuploidies on chromosomal stability

: Marie Curie Initial Training Network Project PLOIDYNET: Mar Soto, Rene H. Medema FP7-PEOPLE-2013; KWF Kankerbestrijding (DCS): Jonne A. Raaijmakers KWF- Young Investigator Grant- 12233. The funders had no ... acquisition, and analysis of CNV and RNA sequencing experiments. Data curation: Dorine C. Hintzen, Mar Soto, Michael Schubert, Bjorn Bakker. Formal analysis: Dorine C. Hintzen, Bjorn Bakker, Karoly Szuhai

The rise of the distributions: why non-normality is important for understanding the transcriptome and beyond

. Mar Open Access Review First Online: 07 January 2019 20 Shares 585 Downloads Abstract The application of statistics has been instrumental in clarifying our understanding of the genome ... defined combination of unimodal distributions, and therefore, has been a popular modeling option for retaining normal distributions while investigating the presence of clustering in the data (Mar and

Integrating Value Considerations in the Decision Making for the Design of Biorefineries

Biobased production has been promoted as a sustainable alternative to fossil resources. However, controversies over its impact on sustainability highlight societal concerns, value tensions and uncertainties that have not been taken into account during its development. In this work, the consideration of stakeholders’ values in a biorefinery design project is investigated. Value...

Ribosome profiling at isoform level reveals evolutionary conserved impacts of differential splicing on the proteome

2601 , Australia 2 Max Delbrück Center for Molecular Medicine in the Helmholtz Association , Berlin 13125 , Germany 3 IMIM - Hospital del Mar Medical Research Institute , E08003 Barcelona , Spain 4

Introduction

Languages Dorien Nieuwenhuijsen 0 Mar Garachana Camarero 0 0 Faculty of Humanities, Department of Languages, Literature and Communication, Utrecht Institute of Linguistics OTS, Utrecht University

Improved selection of participants in genetic longevity studies: family scores revisited

Not applicable. Funding Mar Rodríguez-Girondo has received financial support from MTM2017–89422-P (MINECO/AEI/FEDER,UE) project. The funders had no role in study design, data collection and analysis ... 2, 2333, ZA, Leiden, the Netherlands Mar Rodríguez-Girondo Department of Biomedical Data Sciences, Section of Molecular Epidemiology, Leiden University Medical Center, Albinusdreef 2, 2333, ZA

Viraemic-time predicts mortality among people living with HIV on second-line antiretroviral treatment in Myanmar: A retrospective cohort study

curation: Htay Thet Mar, Moe Pyae Thandar. 12 / 16 Formal analysis: Anita Mesic, Tom Decroo, Bart K. M. Jacobs. Investigation: Anita Mesic, Htay Thet Mar, Moe Pyae Thandar, Thin Thin Thwe, Aung Aung Kyaw ... , Lutgarde Lynen. Visualization: Anita Mesic. Writing – original draft: Anita Mesic. Writing – review & editing: Anita Mesic, Tom Decroo, Htay Thet Mar, Bart K. M. Jacobs, Moe Pyae Thandar, Thin Thin Thwe