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MAM-E17 rat model impairments on a novel continuous performance task: effects of potential cognitive enhancing drugs

cm) modified to include a touch-sensitive monitor (Elo Touch Solutions, Inc., Milpitas, CA, USA; see Mar et al. 2013; Oomen et al. 2013) controlled through in-house software (Visual Basic 2010 ... antinociceptive agent acting vianeuronal nicotinic acetylcholine receptors: II. In vivo characterization . J Pharmacol Exp Ther 285 : 787 - 794 . doi: 10 .1002/(ISSN) 2052 - 1707 Bari A , Eagle DM , Mar AC et al

Key Knowledge Gaps for Plasmodium vivax Control and Elimination

There is inadequate understanding of the biology, pathology, transmission, and control of Plasmodium vivax, the geographically most widespread cause of human malaria. During the last decades, study of this species was neglected, in part due to the erroneous belief that it is intrinsically benign. In addition, many technical challenges in culturing the parasite also hampered ...

Executive Functioning in Men with Schizophrenia and Substance Use Disorders. Influence of Lifetime Suicide Attempts

Background Lifetime suicide attempts in patients with comorbidity between psychotic disorders and Substance Use Disorder (SUD), known as dual diagnosis, was associated with a worse clinical and cognitive state, poor prognosis and premature death. However, to date no previous study has examined the cognitive performance of these patients considering as independent the presence or ...

Correlates of sex trading among male non-injecting drug users in Myanmar: a cross-sectional study

Background Sex trading is a recognized risk factor for human immune deficiency virus infection and other sexually transmitted infections among non-injecting drug users (NIDUs). However, very little research has addressed the factors associated with sex trading among male NIDUs in Myanmar. Methods A cross-sectional study was conducted from January to February 2010 using the ...

Bleeding Risk with Long-Term Low-Dose Aspirin: A Systematic Review of Observational Studies

Background Low-dose aspirin has proven effectiveness in secondary and primary prevention of cardiovascular events, but is also associated with an increased risk of major bleeding events. For primary prevention, this absolute risk must be carefully weighed against the benefits of aspirin; such assessments are currently limited by a lack of data from general populations. Methods ...

Mixtures of Two Bile Alcohol Sulfates Function as a Proximity Pheromone in Sea Lamprey

Unique mixtures of pheromone components are commonly identified in insects, and have been shown to increase attractiveness towards conspecifics when reconstructed at the natural ratio released by the signaler. In previous field studies of pheromones that attract female sea lamprey (Petromyzon marinus, L.), putative components of the male-released mating pheromone included the newly ...

Muscle cell identity requires Pax7-mediated lineage-specific DNA demethylation

Background Skeletal muscle stem cells enable the formation, growth, maintenance, and regeneration of skeletal muscle throughout life. The regeneration process is compromised in several pathological conditions, and muscle progenitors derived from pluripotent stem cells have been suggested as a potential therapeutic source for tissue replacement. DNA methylation is an important ...

Mechanism of Copper Uptake from Blood Plasma Ceruloplasmin by Mammalian Cells

Ceruloplasmin, the main copper binding protein in blood plasma, has been of particular interest for its role in efflux of iron from cells, but has additional functions. Here we tested the hypothesis that it releases its copper for cell uptake by interacting with a cell surface reductase and transporters, producing apoceruloplasmin. Uptake and transepithelial transport of copper ...

New Roles for Corticosteroid Binding Globulin and Opposite Expression Profiles in Lung and Liver

: 162 - 7 . PMID: 10474016 11. del Mar Grasa M , Cabot C , Adán C , de Matteis R , Esteve M , Cinti S , et al. Corticosteroid-binding globulin synthesis and distribution in rat white adipose tissue . Mol ... pancreatitis is mediated by the liver . Ann Surg . 1999 ; 229 : 230 - 6 . PMID: 10024105 18. del Mar Grasa M , Serrano M , Fernández-López JA , Alemany M. Corticosterone inhibits the lipid-mobilizing effects of

PEGylated IL-10 Activates Kupffer Cells to Control Hypercholesterolemia

. Competing Interests: The authors have the following interests: Ivan H. Chan, Dennis Van Hoof, Marina Abramova, Melissa Bilardello, Elliot Mar, Brett Jorgensen, Scott McCauley, Harminder Bal, Martin Oft, Peter ... . 2006 ; 281 ( 10 ): 6316 - 24 . doi: 10 .1074/jbc. M508608200 PMID: 16352613 . 4. Chan IH , Wu V , Bilardello M , Mar E , Oft M , Van Vlasselaer P , et al. The Potentiation of IFN-gamma and Induction of

Mesopelagic N2 Fixation Related to Organic Matter Composition in the Solomon and Bismarck Seas (Southwest Pacific)

Dinitrogen (N2) fixation was investigated together with organic matter composition in the mesopelagic zone of the Bismarck (Transect 1) and Solomon (Transect 2) Seas (Southwest Pacific). Transparent exopolymer particles (TEP) and the presence of compounds sharing molecular formulae with saturated fatty acids and sugars, as well as dissolved organic matter (DOM) compounds containing ...

Glycerol Production from Glucose and Fructose by 3T3-L1 Cells: A Mechanism of Adipocyte Defense from Excess Substrate

Cultured adipocytes (3T3-L1) produce large amounts of 3C fragments; largely lactate, depending on medium glucose levels. Increased glycolysis has been observed also in vivo in different sites of rat white adipose tissue. We investigated whether fructose can substitute glucose as source of lactate, and, especially whether the glycerol released to the medium was of lipolytic or ...

Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development

; 15 ( 10 ): 1388 - 92 . doi: 10.1101/gr.3820805 PMID: 16204192; PubMed Central PMCID: PMC1240081. 4. Mar JC , Rubio R , Quackenbush J. Inferring steady state single-cell gene expression distributions ... the United States of America . 1997 ; 94 ( 3 ): 814 - 9 . PMID: 9023339 ; PubMed Central PMCID : PMC19596 . 13. Mar JC , Matigian NA , Mackay-Sim A , Mellick GD , Sue CM , Silburn PA , et al. Variance

Selective Pressures Explain Differences in Flower Color among Gentiana lutea Populations

Flower color variation among plant populations might reflect adaptation to local conditions such as the interacting animal community. In the northwest Iberian Peninsula, flower color of Gentiana lutea varies longitudinally among populations, ranging from orange to yellow. We explored whether flower color is locally adapted and the role of pollinators and seed predators as agents of ...

RNA-Seq reveals a xenobiotic stress response in the soybean aphid, Aphis glycines, when fed aphid-resistant soybean

Background While much recent research has expanded our understanding of the molecular interactions between aphids and their host plants, it is lacking for the soybean aphid, Aphis glycines. Since its North American invasion, A. glycines has become one of the most damaging insect pests on this important crop. Five soybean genes for host plant resistance to A. glycines have been ...

Gut Microbiota Dynamics during Dietary Shift in Eastern African Cichlid Fishes

, 4 Evolutionary Genomics Group, Institut Hospital del Mar d'Investigacions Mediques (IMIM) , Barcelona , Spain , 5 University Pompeu Fabra (UPF) , Barcelona , Spain , 6 Catalan Institution for Research

Development and Characterization of an Effective Food Allergy Model in Brown Norway Rats

Background Food allergy (FA) is an adverse health effect produced by the exposure to a given food. Currently, there is no optimal animal model of FA for the screening of immunotherapies or for testing the allergenicity of new foods. Objective The aim of the present study was to develop an effective and rapid model of FA in Brown Norway rats. In order to establish biomarkers of FA ...

Factors Controlling Vegetation Fires in Protected and Non-Protected Areas of Myanmar

): 5403 - 5408 . PMID: 16554375 30. Lambin EF , Meyfroidt P. Global land use change, economic globalization, and the looming land scarcity . Proc Natl Acad Sci U S A. 2011 Mar 1 ; 108 ( 9 ): 3465 - 3472 ... areas in the Brazilian Amazon . Proc Natl Acad Sci U S A. 2013 Mar 26 ; 110 ( 13 ): 4956 - 4961 . doi: 10.1073/pnas.1214786110 PMID: 23479648 36. Nolte C , Agrawal A. Linking management effectiveness

Chemokine Receptor Ccr6 Deficiency Alters Hepatic Inflammatory Cell Recruitment and Promotes Liver Inflammation and Fibrosis

Chronic liver diseases are characterized by a sustained inflammatory response in which chemokines and chemokine-receptors orchestrate inflammatory cell recruitment. In this study we investigated the role of the chemokine receptor CCR6 in acute and chronic liver injury. In the absence of liver injury Ccr6-/- mice presented a higher number of hepatic macrophages and increased ...