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Comparative Genomics Reveals Thousands of Novel Chemosensory Genes and Massive Changes in Chemoreceptor Repertories across Chelicerates

Chemoreception is a widespread biological function that is essential for the survival, reproduction, and social communication of animals. Though the molecular mechanisms underlying chemoreception are relatively well known in insects, they are poorly studied in the other major arthropod lineages. Current availability of a number of chelicerate genomes constitutes a great...

Does the rising placebo response impact antihypertensive clinical trial outcomes? An analysis of data from the Food and Drug Administration 1990-2016

. Author Contributions Conceptualization: Arif Khan, Kaysee Fahl Mar, Walter A. Brown. Data curation: Kaysee Fahl Mar. 15 / 17 Formal analysis: Kaysee Fahl Mar. Investigation: Kaysee Fahl Mar ... . Methodology: Arif Khan, Kaysee Fahl Mar, Walter A. Brown. Project administration: Arif Khan. Supervision: Arif Khan, Joshua Schilling, Walter A. Brown. Validation: Arif Khan, Kaysee Fahl Mar, Joshua

A transcription network of interlocking positive feedback loops maintains intracellular iron balance in archaea

Iron is required for key metabolic processes but is toxic in excess. This circumstance forces organisms across the tree of life to tightly regulate iron homeostasis. In hypersaline lakes dominated by archaeal species, iron levels are extremely low and subject to environmental change; however, mechanisms regulating iron homeostasis in archaea remain unclear. In previous work, we...

Weight Management in Patients with Type 1 Diabetes and Obesity

surgeries are valid methods for weight management in patients with T1D. Compliance with Ethical Standards Conflict of Interest Adham Mottalib, Megan Kasetty, Jessica Y. Mar, Taha Elseaidy, and Sahar

A user-friendly tool to evaluate the effectiveness of no-take marine reserves

Conceptualization: Juan Carlos Villaseñor-Derbez, Caio Faro, Melaina Wright, Jael MartÂõnez, Sean Fitzgerald, Stuart Fulton, Maria del Mar Mancha-Cisneros, Gavin McDonald, Fiorenza Micheli, Alvin SuaÂrez, Jorge Torre ... : Juan Carlos Villaseñor-Derbez, Caio Faro, Melaina Wright, Jael MartÂõnez, Christopher Costello. Methodology: Juan Carlos Villaseñor-Derbez, Caio Faro, Melaina Wright, Jael MartÂõnez, Maria del Mar

MAM-E17 rat model impairments on a novel continuous performance task: effects of potential cognitive enhancing drugs

cm) modified to include a touch-sensitive monitor (Elo Touch Solutions, Inc., Milpitas, CA, USA; see Mar et al. 2013; Oomen et al. 2013) controlled through in-house software (Visual Basic 2010 ... antinociceptive agent acting vianeuronal nicotinic acetylcholine receptors: II. In vivo characterization . J Pharmacol Exp Ther 285 : 787 - 794 . doi: 10 .1002/(ISSN) 2052 - 1707 Bari A , Eagle DM , Mar AC et al

Key Knowledge Gaps for Plasmodium vivax Control and Elimination

There is inadequate understanding of the biology, pathology, transmission, and control of Plasmodium vivax, the geographically most widespread cause of human malaria. During the last decades, study of this species was neglected, in part due to the erroneous belief that it is intrinsically benign. In addition, many technical challenges in culturing the parasite also hampered...

High-permeability region size on perfusion CT predicts hemorrhagic transformation after intravenous thrombolysis in stroke

. Liebeskind, GoÈtz Thomalla, Bijoy K. Menon, Andrew Demchuk, Max Wintermark, Salvador Pedraza, Mar Castellanos. Data curation: Pepus Daunis-i-Estadella, Mar Castellanos. Formal analysis: Josep Puig, Gerard ... Blasco, Pepus Daunis-i-Estadella, Mar Castellanos. Funding acquisition: Mar Castellanos. Investigation: Josep Puig, MarÂõa Carrillo-GarcÂõa, Carlos Aboud, MarÂõa HernaÂndez-PeÂrez, JoaquÂõn Serena

Correlates of sex trading among male non-injecting drug users in Myanmar: a cross-sectional study

Background Sex trading is a recognized risk factor for human immune deficiency virus infection and other sexually transmitted infections among non-injecting drug users (NIDUs). However, very little research has addressed the factors associated with sex trading among male NIDUs in Myanmar. Methods A cross-sectional study was conducted from January to February 2010 using the...

Preclinical Immunomodulation by the Probiotic Bifidobacterium breve M-16V in Early Life

This study aimed to investigate the effect of supplementation with the probiotic Bifidobacterium breve M-16V on the maturation of the intestinal and circulating immune system during suckling. In order to achieve this purpose, neonatal Lewis rats were supplemented with the probiotic strain from the 6th to the 18th day of life. The animals were weighed during the study, and faecal...

Executive Functioning in Men with Schizophrenia and Substance Use Disorders. Influence of Lifetime Suicide Attempts

Background Lifetime suicide attempts in patients with comorbidity between psychotic disorders and Substance Use Disorder (SUD), known as dual diagnosis, was associated with a worse clinical and cognitive state, poor prognosis and premature death. However, to date no previous study has examined the cognitive performance of these patients considering as independent the presence or...

Mixtures of Two Bile Alcohol Sulfates Function as a Proximity Pheromone in Sea Lamprey

Unique mixtures of pheromone components are commonly identified in insects, and have been shown to increase attractiveness towards conspecifics when reconstructed at the natural ratio released by the signaler. In previous field studies of pheromones that attract female sea lamprey (Petromyzon marinus, L.), putative components of the male-released mating pheromone included the...

Bleeding Risk with Long-Term Low-Dose Aspirin: A Systematic Review of Observational Studies

Background Low-dose aspirin has proven effectiveness in secondary and primary prevention of cardiovascular events, but is also associated with an increased risk of major bleeding events. For primary prevention, this absolute risk must be carefully weighed against the benefits of aspirin; such assessments are currently limited by a lack of data from general populations. Methods...

Muscle cell identity requires Pax7-mediated lineage-specific DNA demethylation

Background Skeletal muscle stem cells enable the formation, growth, maintenance, and regeneration of skeletal muscle throughout life. The regeneration process is compromised in several pathological conditions, and muscle progenitors derived from pluripotent stem cells have been suggested as a potential therapeutic source for tissue replacement. DNA methylation is an important...

Mechanism of Copper Uptake from Blood Plasma Ceruloplasmin by Mammalian Cells

Ceruloplasmin, the main copper binding protein in blood plasma, has been of particular interest for its role in efflux of iron from cells, but has additional functions. Here we tested the hypothesis that it releases its copper for cell uptake by interacting with a cell surface reductase and transporters, producing apoceruloplasmin. Uptake and transepithelial transport of copper...

New Roles for Corticosteroid Binding Globulin and Opposite Expression Profiles in Lung and Liver

: 162 - 7 . PMID: 10474016 11. del Mar Grasa M , Cabot C , Adán C , de Matteis R , Esteve M , Cinti S , et al. Corticosteroid-binding globulin synthesis and distribution in rat white adipose tissue . Mol ... pancreatitis is mediated by the liver . Ann Surg . 1999 ; 229 : 230 - 6 . PMID: 10024105 18. del Mar Grasa M , Serrano M , Fernández-López JA , Alemany M. Corticosterone inhibits the lipid-mobilizing effects of

Mesopelagic N2 Fixation Related to Organic Matter Composition in the Solomon and Bismarck Seas (Southwest Pacific)

Dinitrogen (N2) fixation was investigated together with organic matter composition in the mesopelagic zone of the Bismarck (Transect 1) and Solomon (Transect 2) Seas (Southwest Pacific). Transparent exopolymer particles (TEP) and the presence of compounds sharing molecular formulae with saturated fatty acids and sugars, as well as dissolved organic matter (DOM) compounds...

Glycerol Production from Glucose and Fructose by 3T3-L1 Cells: A Mechanism of Adipocyte Defense from Excess Substrate

Cultured adipocytes (3T3-L1) produce large amounts of 3C fragments; largely lactate, depending on medium glucose levels. Increased glycolysis has been observed also in vivo in different sites of rat white adipose tissue. We investigated whether fructose can substitute glucose as source of lactate, and, especially whether the glycerol released to the medium was of lipolytic or...

RNA-Seq reveals a xenobiotic stress response in the soybean aphid, Aphis glycines, when fed aphid-resistant soybean

Background While much recent research has expanded our understanding of the molecular interactions between aphids and their host plants, it is lacking for the soybean aphid, Aphis glycines. Since its North American invasion, A. glycines has become one of the most damaging insect pests on this important crop. Five soybean genes for host plant resistance to A. glycines have been...