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SlowMo, a digital therapy targeting reasoning in paranoia, versus treatment as usual in the treatment of people who fear harm from others: study protocol for a randomised controlled trial

Paranoia is one of the most common symptoms of schizophrenia-spectrum disorders, and is associated with significant distress and disruption to the person’s life. Developing more effective and accessible psychological interventions for paranoia is a clinical priority. Our research team has approached this challenge in two main ways: firstly, by adopting an interventionist causal...

Leveraging workflow control patterns in the domain of clinical practice guidelines

Background Clinical practice guidelines (CPGs) include recommendations describing appropriate care for the management of patients with a specific clinical condition. A number of representation languages have been developed to support executable CPGs, with associated authoring/editing tools. Even with tool assistance, authoring of CPG models is a labor-intensive task. We aim at...

Guidelines for Biomarker of Food Intake Reviews (BFIRev): how to conduct an extensive literature search for biomarker of food intake discovery

Identification of new biomarkers of food and nutrient intake has developed fast over the past two decades and could potentially provide important new tools for compliance monitoring and dietary intake assessment in nutrition and health science. In recent years, metabolomics has played an important role in identifying a large number of putative biomarkers of food intake (BFIs...

A scheme for a flexible classification of dietary and health biomarkers

Manach 5 Lorraine Brennan 4 Lydia A. Afman 9 David S. Wishart 8 Cristina Andres-Lacueva 3 11 Mar Garcia-Aloy 3 11 Hans Verhagen 10 12 Edith J. M. Feskens 9 Lars O. Dragsted 0 0 Department of Nutrition

A guide to performing a peer review of randomised controlled trials

that only emerges after a detailed read or © 2015 Del Mar and Hoffmann. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http

Body image satisfaction and weight concerns among a Mediterranean adult population

Background People tend to underestimate their current weight and overestimate their height minimizing health risk factors. The aim of this study was to assess body weight satisfaction, acceptance of body image, weight concern and dieting habits among a Mediterranean adult population. Methods Cross-sectional survey was carried out (2009–2010) in the Balearic Islands, Spain. A...

Impact of hyperkalaemia definition on incidence assessment: implications for epidemiological research based on a large cohort study in newly diagnosed heart failure patients in primary care

failure patients in primary care Mar Martín-Pérez Ana Ruigómez Alexander Michel Luis A. García Rodríguez Background: Various definitions of hyperkalaemia have been used in clinical research, and data

Dietary patterns are associated with lung function among Spanish smokers without respiratory disease

Background Diet can help preserve lung function in smokers, in addition to avoidance of smoking. The study aimed to evaluate associations between dietary patterns and lung function in smokers without respiratory disease. Methods This cross-sectional study analysed baseline data from randomised representative smokers without respiratory disease (n = 207, aged 35–70 years...

Malaria incidence in Myanmar 2005–2014: steady but fragile progress towards elimination

Myat Phone Kyaw 4 Chit Soe 3 Mar Mar Kyi 6 Josh Hanson 5 6 7 0 Myanmar Medical Association , Yangon , Myanmar 1 Department of Medical Care, Ministry of Health , Nay Pyi Taw , Myanmar 2 Department of

Adiposity markers and lung function in smokers: a cross-sectional study in a Mediterranean population

Background The aim of this study was to assess the association of key adiposity markers with lung function in smokers without respiratory disease in a Mediterranean population. Methods We performed a cross-sectional study with baseline data from a representative sample of the ESPITAP study in Spain. Participants were 738 smokers (52.3% men) without respiratory disease, aged 35 to...

Muscle cell identity requires Pax7-mediated lineage-specific DNA demethylation

Background Skeletal muscle stem cells enable the formation, growth, maintenance, and regeneration of skeletal muscle throughout life. The regeneration process is compromised in several pathological conditions, and muscle progenitors derived from pluripotent stem cells have been suggested as a potential therapeutic source for tissue replacement. DNA methylation is an important...

Parents’ beliefs and knowledge about the management of acute otitis media: a qualitative study

provided by the Australian Government Department of Health. Tammy C Hoffmann and Chris Del Mar are chief investigators at the Centre for Research Excellence in Minimising Antibiotic Resistance from Acute ... Respiratory Infections (NHMRC grant 1044904). 1. Venekamp RP , Sanders S , Glasziou PP , Del Mar CB , Rovers MM . Antibiotics for acute otitis media in children . Cochrane Database Syst Rev . 2013 ; 1

A literature review and case report of hand, foot and mouth disease in an immunocompetent adult

Background To report an uncommon case of hand, foot and mouth disease, (HFMD) in an immunocompetent adult; a highly infectious disease, characterized by the appearance of vesicles on the mouth, hands and feet, associated with coxsackieviruses and enteroviruses; including a literature review. Case report A 23 year Caucasian male with no medical or surgical history, no allergies...

The geographical distribution and prevalence of Echinococcus multilocularis in animals in the European Union and adjacent countries: a systematic review and meta-analysis

Background This study aimed to provide a systematic review on the geographical distribution of Echinococcus multilocularis in definitive and intermediate hosts in the European Union (EU) and adjacent countries (AC). The relative importance of the different host species in the life-cycle of this parasite was highlighted and gaps in our knowledge regarding these hosts were...

Natural history of cerebrotendinous xanthomatosis: a paediatric disease diagnosed in adulthood

Cerebrotendinous xanthomatosis (CTX) is among the few inherited neurometabolic disorders amenable to specific treatment. It is easily diagnosed using plasma cholestanol. We wished to delineate the natural history of the most common neurological and non-neurological symptoms in thirteen patients with CTX. Diarrhea almost always developed within the first year of life. Cataract and...

Thermal reference points as an index for monitoring body temperature in marine mammals

. Mar Melero is the recipient of a predoctoral fellowship from the PhD student grant program of Complutense University of Madrid and Víc‑ tor Rodríguez‑Prieto is the recipient of an FPU grant from the ... ‑ Vizcaíno JM . Identification of the pattern of appearance and development of thermal windows in the skin of juvenile Pacific walruses (Odobenus rosmarus divergens) in a controlled environment . Mar Mamm Sci

First molecular determination of herpesvirus from two mysticete species stranded in the Mediterranean Sea

las Ciencias of Valencia; and the VISAVET Center of Complutense University of Madrid. Mar Melero is the recipient of a PhD student grant from Complutense University of Madrid, and Consuelo Rubio-Guerri ... , Pastoret PP. Herpes-like virus in dusky dolphins, Lagenorhynchus obscurus, from coastal Peru . Mar Mamm Sci . 1994 ; 10 : 354 - 9 . 7. Smolarek Benson KA , Manire CA , Ewing RY , Saliki JT , Townsend FI

Evaluation of health benefits and harms of the breast cancer screening programme in the Basque Country using discrete event simulation

, Hospital del Mar - IMIM (Hospital del Mar Medical Research Institute) , Passeig Maritim 25-29, 08003 Barcelona , Spain 6 Department of Public Health, Erasmus University Medical Center Rotterdam , Dr ... Screening Trial. Cancer . 2003 ; 97 : 2387 - 96 . 5. Arrospide A , Forne C , Rue M , Tora N , Mar J , Bare M. An assessment of existing models for individualized breast cancer risk estimation in a screening