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Comparative Genomics Reveals Thousands of Novel Chemosensory Genes and Massive Changes in Chemoreceptor Repertories across Chelicerates

Chemoreception is a widespread biological function that is essential for the survival, reproduction, and social communication of animals. Though the molecular mechanisms underlying chemoreception are relatively well known in insects, they are poorly studied in the other major arthropod lineages. Current availability of a number of chelicerate genomes constitutes a great...

A transcription network of interlocking positive feedback loops maintains intracellular iron balance in archaea

Iron is required for key metabolic processes but is toxic in excess. This circumstance forces organisms across the tree of life to tightly regulate iron homeostasis. In hypersaline lakes dominated by archaeal species, iron levels are extremely low and subject to environmental change; however, mechanisms regulating iron homeostasis in archaea remain unclear. In previous work, we...

The structure of transcription termination factor Nrd1 reveals an original mode for GUAA recognition

Transcription termination of non-coding RNAs is regulated in yeast by a complex of three RNA binding proteins: Nrd1, Nab3 and Sen1. Nrd1 is central in this process by interacting with Rbp1 of RNA polymerase II, Trf4 of TRAMP and GUAA/G terminator sequences. We lack structural data for the last of these binding events. We determined the structures of Nrd1 RNA binding domain and...

New Genes and Functional Innovation in Mammals

Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF) , Barcelona , Spain 1 Evolutionary Genomics Group, Research Programme in Biomedical Informatics, Hospital del Mar Research

Short-term and delayed effects of mother death on calf mortality in Asian elephants

Burma) (Mar et al. 2012; Robinson et al. 2012; Mumby et al. 2013a, 2013b; Hayward et al. 2014; Lahdenperä et al. 2014) . Myanmar has the largest captive Asian elephant population in the world and the ... include natural causes such as starvation, tiger attacks, and a range of recorded diseases, as well as accidents (for death causes of calves see Mar et al. 2012; for seasonal variation in all age groups

Short-term and delayed effects of mother death on calf mortality in Asian elephants

Burma) (Mar et al. 2012; Robinson et al. 2012; Mumby et al. 2013a, 2013b; Hayward et al. 2014; Lahdenperä et al. 2014) . Myanmar has the largest captive Asian elephant population in the world and the ... include natural causes such as starvation, tiger attacks, and a range of recorded diseases, as well as accidents (for death causes of calves see Mar et al. 2012; for seasonal variation in all age groups

Gene Expression Profiling in the Hibernating Primate, Cheirogaleus Medius

D. Yoder 1 0 Evolutionary Genomics Group, Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Research Institute (IMIM), Universitat Pompeu Fabra (UPF) , Barcelona , Spain 1

Not in my backyard: a systematic review of clinicians

general practices. BMJ Open 2014; 4: e006245. 16 Spurling G, Doust J, Del Mar C et al. Antibiotics for bronchiolitis in children. Cochrane Database Syst Rev 2011; issue 6: CD005189. 17 Venekamp R, Sanders S ... , Glasziou P et al. Antibiotics for acute otitis media in children. Cochrane Database Syst Rev 2013; issue 1: CD000219. 18 Spinks A, Glasziou P, Del Mar C. Antibiotics for sore throat (Review). Cochrane

Key Role of Amino Acid Repeat Expansions in the Functional Diversification of Duplicated Transcription Factors

, Spain 2 Evolutionary Genomics Group, Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Research Institute (IMIM) , Barcelona , Spain 3 Centro de Investigacion Biome`dica en Red en

Quantifying sequence and structural features of protein–RNA interactions

Increasing awareness of the importance of protein–RNA interactions has motivated many approaches to predict residue-level RNA binding sites in proteins based on sequence or structural characteristics. Sequence-based predictors are usually high in sensitivity but low in specificity; conversely structure-based predictors tend to have high specificity, but lower sensitivity. Here we...

Addressing resistance to antibiotics in systematic reviews of antibiotic interventions | Journal of Antimicrobial Chemotherapy | Oxford Academic

Cullum 5 Hywel C. Williams 4 Alan Smyth 9 Nicole Skoetz 8 Chris Del Mar 2 Anne G. M. Schilder 10 Dafna Yahav 3 David Tovey 11 0 Cochrane Infectious Diseases Group, Liverpool School of Tropical Medicine

Effects of HIV-1 reverse transcriptase connection subdomain mutations on polypurine tract removal and initiation of (+)-strand DNA synthesis

HIV-1 reverse transcriptase (RT) connection subdomain mutations at positions 348, 369 and 376 have been associated with resistance to non-nucleoside RT inhibitors (NNRTIs). N348I may interfere with the initiation of (+)-strand DNA synthesis by reducing polypurine tract (PPT) removal in the presence of nevirapine. The effect of NNRTIs on the RNase H-mediated cleavage of PPT...

Intensity drift removal in LC/MS metabolomics by common variance compensation

Liquid chromatography coupled to mass spectrometry (LC/MS) has become widely used in Metabolomics. Several artefacts have been identified during the acquisition step in large LC/MS metabolomics experiments, including ion suppression, carryover or changes in the sensitivity and intensity. Several sources have been pointed out as responsible for these effects. In this context, the...

Conservative site-specific and single-copy transgenesis in human LINE-1 elements

Genome engineering of human cells plays an important role in biotechnology and molecular medicine. In particular, insertions of functional multi-transgene cassettes into suitable endogenous sequences will lead to novel applications. Although several tools have been exploited in this context, safety issues such as cytotoxicity, insertional mutagenesis and off-target cleavage...

Chaetognath assemblages along the Pacific Coast and adjacent inland waters of the Philippines: relative importance of oceanographic and biological factors

Mary Mar P. Noblezada 0 1 Wilfredo L. Campos 0 0 OceanBio Laboratory, Division of Biological Sciences, College of Arts and Sciences, University of the Philippines Visayas , Iloilo, Miagao 5023