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Short-term and delayed effects of mother death on calf mortality in Asian elephants

Burma) (Mar et al. 2012; Robinson et al. 2012; Mumby et al. 2013a, 2013b; Hayward et al. 2014; Lahdenperä et al. 2014) . Myanmar has the largest captive Asian elephant population in the world and the ... include natural causes such as starvation, tiger attacks, and a range of recorded diseases, as well as accidents (for death causes of calves see Mar et al. 2012; for seasonal variation in all age groups

Gene Expression Profiling in the Hibernating Primate, Cheirogaleus Medius

D. Yoder 1 0 Evolutionary Genomics Group, Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Research Institute (IMIM), Universitat Pompeu Fabra (UPF) , Barcelona , Spain 1

Key Role of Amino Acid Repeat Expansions in the Functional Diversification of Duplicated Transcription Factors

, Spain 2 Evolutionary Genomics Group, Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Research Institute (IMIM) , Barcelona , Spain 3 Centro de Investigacion Biome`dica en Red en

Quantifying sequence and structural features of protein–RNA interactions

Increasing awareness of the importance of protein–RNA interactions has motivated many approaches to predict residue-level RNA binding sites in proteins based on sequence or structural characteristics. Sequence-based predictors are usually high in sensitivity but low in specificity; conversely structure-based predictors tend to have high specificity, but lower sensitivity. Here we ...

Effects of HIV-1 reverse transcriptase connection subdomain mutations on polypurine tract removal and initiation of (+)-strand DNA synthesis

HIV-1 reverse transcriptase (RT) connection subdomain mutations at positions 348, 369 and 376 have been associated with resistance to non-nucleoside RT inhibitors (NNRTIs). N348I may interfere with the initiation of (+)-strand DNA synthesis by reducing polypurine tract (PPT) removal in the presence of nevirapine. The effect of NNRTIs on the RNase H-mediated cleavage of ...

Conservative site-specific and single-copy transgenesis in human LINE-1 elements

Genome engineering of human cells plays an important role in biotechnology and molecular medicine. In particular, insertions of functional multi-transgene cassettes into suitable endogenous sequences will lead to novel applications. Although several tools have been exploited in this context, safety issues such as cytotoxicity, insertional mutagenesis and off-target cleavage ...

Intensity drift removal in LC/MS metabolomics by common variance compensation

Liquid chromatography coupled to mass spectrometry (LC/MS) has become widely used in Metabolomics. Several artefacts have been identified during the acquisition step in large LC/MS metabolomics experiments, including ion suppression, carryover or changes in the sensitivity and intensity. Several sources have been pointed out as responsible for these effects. In this context, the ...

Glycogen accumulation underlies neurodegeneration and autophagy impairment in Lafora disease

authors thank Mar´ıa Sa´nchez-Enciso, Natalia Plana, Anna Adrover and Emma Veza for their technical assistance, Isabel Saez for critical review and Tanya Yates for correcting the English version of the

Chaetognath assemblages along the Pacific Coast and adjacent inland waters of the Philippines: relative importance of oceanographic and biological factors

Mary Mar P. Noblezada 0 1 Wilfredo L. Campos 0 0 OceanBio Laboratory, Division of Biological Sciences, College of Arts and Sciences, University of the Philippines Visayas , Iloilo, Miagao 5023

Genome-Wide Analysis of Wild-Type Epstein–Barr Virus Genomes Derived from Healthy Individuals of the 1000 Genomes Project

, Hospital del Mar Research Institute (IMIM), Universitat Pompeu Fabra (UPF) , Barcelona, Spain Most people in the world (~90%) are infected by the Epstein-Barr virus (EBV), which establishes itself

Salinity effects on asexual reproduction of Carybdea sp. (Cnidaria: Cubozoa)

near Denia, Spain (south-western Mediterranean) . Mar. Biodivers. Records , 4 , 1 - 6 . Brotz , L. , Cheung , W. W. L. , Kleisner , K. et al. ( 2012 ) Increasing jellyfish populations: trends in large ... ) Development of the cubomedusae , Carybdea marsupialis.Proc. Ass. Is. Mar. Lab. Caribb. , 9 , 1 . Fischer , A. B. and Hofmann , D. K. ( 2004 ) Budding, bud morphogenesis, and regeneration in Carybdea marsupialis

Improving Genome-Wide Scans of Positive Selection by Using Protein Isoforms of Similar Length

Biomedical Informatics (GRIB), Hospital del Mar Research Institute (IMIM), Universitat Pompeu Fabra (UPF) , Barcelona, Spain Large-scale evolutionary studies often require the automated construction of

Imagine All the People: How the Brain Creates and Uses Personality Models to Predict Behavior

(Mar 2011) as well as when spontaneous and intentional trait inferences are being made (Ma et al. 2011). During these moments, a subprocess may be linking inferred mental states to broader personality ... temporal poles. These regions are reliably observed during studies of mental inference (Mar 2011) and are consistent with the observed overlap between autobiographical memory and mentalizing (Spreng et al

Deep-sea sponge grounds enhance diversity and abundance of epibenthic megafauna in the Northwest Atlantic

Beazley, L. I., Kenchington E. L., Murillo, F. J., and Sacau, M. 2013. Deep-sea sponge grounds enhance diversity and abundance of epibenthic megafauna in the Northwest Atlantic. – ICES Journal of Marine Science, 70: . The influence of structure-forming deep-water sponge grounds on the composition, diversity, and abundance of the local epibenthic megafaunal community of the Flemish ...

Stress and body condition are associated with climate and demography in Asian elephants

maintaining the world’s largest remaining semicaptive population of almost 5000 elephants (Mar et al., 2012) and the second largest overall population after India with an additional 5000 or fewer wild elephants ... (Sukumar, 2006). Over half of this semi-captive population is owned by the Myanmar Government and employed in the timber industry (Mar, 2007). In common with most other Asian elephant populations worldwide

Heterogeneous Patterns of Gene-Expression Diversification in Mammalian Gene Duplicates

Gene duplication is a major mechanism for molecular evolutionary innovation. Young gene duplicates typically exhibit elevated rates of protein evolution and, according to a number of recent studies, increased expression divergence. However, the nature of these changes is still poorly understood. To gain novel insights into the functional consequences of gene duplication, we have ...

Comparative analysis of human and mouse expression data illuminates tissue-specific evolutionary patterns of miRNAs

MicroRNAs (miRNAs) constitute an important class of gene regulators. While models have been proposed to explain their appearance and expansion, the validation of these models has been difficult due to the lack of comparative studies. Here, we analyze miRNA evolutionary patterns in two mammals, human and mouse, in relation to the age of miRNA families. In this comparative framework, ...

BioBloom tools: fast, accurate and memory-efficient host species sequence screening using bloom filters

Large datasets can be screened for sequences from a specific organism, quickly and with low memory requirements, by a data structure that supports time- and memory-efficient set membership queries. Bloom filters offer such queries but require that false positives be controlled. We present BioBloom Tools, a Bloom filter-based sequence-screening tool that is faster than BWA, Bowtie 2 ...

Stark parameter measurement of Ar ii UV spectral lines

. A. , Mar S. , 1997 , J. Phys. B: At. Mol. Opt. Phys. , 30 , 3141 Aparicio J. A. , Gigosos M. A. , Gonzalez V. R. , Perez C. , de la Rosa M. I. , Mar S. , 1998a , J. Phys. B: At. Mol. Opt. Phys. , 31 ... , 1029 Aparicio J. A. , Perez C. , del Val J. A., Gigosos M. A. , de la Rosa M. I. , Mar S. , 1998b , J. Phys. B: At. Mol. Opt. Phys. , 31 , 4909 Asplund M. , Grevesse N. , Sauval A. J. , Scott P. , 2009

Altered error specificity of RNase H-deficient HIV-1 reverse transcriptases during DNA-dependent DNA synthesis

Asp443 and Glu478 are essential active site residues in the RNase H domain of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT). We have investigated the effects of substituting Asn for Asp443 or Gln for Glu478 on the fidelity of DNA-dependent DNA synthesis of phylogenetically diverse HIV-1 RTs. In M13mp2 lacZα-based forward mutation assays, HIV-1 group M ...