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Economic evaluation of the breast cancer screening programme in the Basque Country: retrospective cost-effectiveness and budget impact analysis

Government , Alameda Rekalde 39, 48008 Bilbao, Bizkaia , Spain 5 Evaluation and Epidemiology Department, Hospital del Mar - IMIM (Hospital del Mar Medical Research Institute) , Passeig Maritim 25-29, 08003 ... . Arrospide A , Rue M , van Ravesteyn NT , Comas M , Larrañaga N , Sarriugarte G , Mar J . Evaluation of health benefits and harms of the breast cancer screening programme in the Basque Country . BMC Cancer

Evaluation of health benefits and harms of the breast cancer screening programme in the Basque Country using discrete event simulation

. The Gothenburg Breast Screening Trial. Cancer . 2003 ; 97 : 2387 - 96 . 5. Arrospide A , Forne C , Rue M , Tora N , Mar J , Bare M. An assessment of existing models for individualized breast cancer risk ... Protection (ed). Luxembourg: Office for Official Publications of the European Communities; 2006 . 14. Comas M , Arrospide A , Mar J , Sala M , Vilaprinyo E , Hernandez C , et al. Budget impact analysis of

Prognostic value of inhibitors of apoptosis proteins (IAPs) and caspases in prostate cancer: caspase-3 forms and XIAP predict biochemical progression after radical prostatectomy

Mar Royuela 0 3 0 Department of Biomedicine and Biotechnology, University of Alcalá, 28871 Alcalá de Henares , Madrid , Spain 1 Department of Urology, Príncipe de Asturias Hospital , 28805 Alcalá

Role of the microtubule-targeting drug vinflunine on cell-cell adhesions in bladder epithelial tumour cells

Background Vinflunine (VFL) is a microtubule-targeting drug that suppresses microtubule dynamics, showing anti-metastatic properties both in vitro and in living cancer cells. An increasing body of evidence underlines the influence of the microtubules dynamics on the cadherin-dependent cell-cell adhesions. E-cadherin is a marker of epithelial-to-mesenchymal transition (EMT) and a ...

Circulating miR-200c and miR-141 and outcomes in patients with breast cancer

Background The deregulation of microRNAs in both tumours and blood has led to the search for microRNAs to indicate the presence of cancer and predict prognosis. We hypothesize the deregulation of miR-200c/miR-141 in the whole blood can identify breast cancer (BC), and could be developed into a prognostic signature. Methods The expression of miR-200c and miR-141 were examined in ...

An assessment of existing models for individualized breast cancer risk estimation in a screening program in Spain

Background The aim of this study was to evaluate the calibration and discriminatory power of three predictive models of breast cancer risk. Methods We included 13,760 women who were first-time participants in the Sabadell-Cerdanyola Breast Cancer Screening Program, in Catalonia, Spain. Projections of risk were obtained at three and five years for invasive cancer using the Gail, ...

Human hematopoietic signal peptide-containing secreted 1 (hHSS1) modulates genes and pathways in glioma: implications for the regulation of tumorigenicity and angiogenesis

-Gill Chris E Lawrence Christopher J Wheeler Ryan Cordner Tristan G Gill Vernon Mar Liron Shiri Lena A Basile Background: Human Hematopoietic Signal peptide-containing Secreted 1 (hHSS1) is a truly

Preoperative chemoradiotherapy in rectal cancer induces changes in the expression of nuclear β-catenin: prognostic significance

Background Preoperative chemoradiotherapy (CRT) is the cornerstone of treatment for locally advanced rectal cancer (LARC). Although high local control is achieved, overall rates of distant control remain suboptimal. Colorectal carcinogenesis is associated with critical alterations of the Wnt/β-catenin pathway involved in proliferation and survival. The aim of this study was to ...

Hakai reduces cell-substratum adhesion and increases epithelial cell invasion

Background The dynamic regulation of cell-cell adhesions is crucial for developmental processes, including tissue formation, differentiation and motility. Adherens junctions are important components of the junctional complex between cells and are necessary for maintaining cell homeostasis and normal tissue architecture. E-cadherin is the prototype and best-characterized protein ...

Influence of IFN-gamma and its receptors in human breast cancer

' contributions IG and MaR designed the study, carried out the immunohistochemistry studies, the Quantitative analysis and participated in discussion. MoR and RP participated in western blot analysis, result ... interpretation and discussion. AR prepared and provided the tumor biological samples and participated in the immunohistochemistry studies. BF performed the statistical analysis and participated discussion. MaR

Role of IAPs in prostate cancer progression: immunohistochemical study in normal and pathological (benign hyperplastic, prostatic intraepithelial neoplasia and cancer) human prostate

Background In this study was investigate IAPs in normal human prostate (NP), benign prostatic hyperplasia (BPH), prostatic intraepithelial neoplasia (PIN) and prostatic carcinoma (PC), and their involvement in apoptosis/proliferation via NF-kB (TNF-α, IL-1) stimulation. Methods Immunohistochemical and Western blot analyses were performed in 10 samples of normal prostates, 35 ...

Serum paraoxonase and arylesterase activities in patients with lung cancer in a Turkish population

Background Lung cancer (LC) is the leading cause of cancer-related deaths. Oxidative DNA damage may contribute to the cancer risk. The antioxidant paraoxonase (PON1) is an endogenous free radical scavenger in the human body. The aim of this study was to determine serum PON1 and arylesterase (ARE) activities in patients with newly diagnosed LC. Methods This case control study ...