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203 papers found.
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Identifying unmet clinical need in hypertrophic cardiomyopathy using national electronic health records

. Supplemental methods. (DOC) Author Contributions Conceptualization: Mar Pujades-Rodriguez, Oliver P. Guttmann, Perry Elliott, Harry Hemingway. Data curation: Mar Pujades-Rodriguez, Arturo Gonzalez-Izquierdo ... , Bram Duyx. Formal analysis: Mar Pujades-Rodriguez. Funding acquisition: Harry Hemingway. Methodology: Mar Pujades-Rodriguez, Oliver P. Guttmann. Project administration: Mar Pujades-Rodriguez

Decisional balance and processes of change in community-recruited with moderate-high versus mild severity of cannabis dependence

Albein-Urios. Formal analysis: Mã del Mar Rueda. The data collection and the field work were performed by the FQM356 research group as part Investigation: Francisca LoÂpez-Torrecillas, Eva MarÂõa LoÂpez

An optimization design proposal of automated guided vehicles for mixed type transportation in hospital environments

Aim The aim of this paper is to present an optimization proposal in the automated guided vehicles design used in hospital logistics, as well as to analyze the impact of its implementation in a real environment. Method This proposal is based on the design of those elements that would allow the vehicles to deliver an extra cart by the towing method. So, the proposal intention is to ...

Trace element contents in toenails are related to regular physical activity in older adults

Conceptualization: Marcela Gonzalez-Gross, Josep A. Tur. Formal analysis: Maria del Mar Bibiloni. Funding acquisition: Antoni Pons. Investigation: Antoni Sureda, Maria del Mar Bibiloni, Alicia Julibert, Raquel ... Aparicio-Ugar riza, Gonzalo Palacios-Le BleÂ. Supervision: Josep A. Tur. Writing ± original draft: Antoni Sureda, Maria del Mar Bibiloni, Josep A. Tur. Writing ± review & editing: Antoni Sureda, Maria del

Procalcitonin for selecting the antibiotic regimen in outpatients with low-risk community-acquired pneumonia using a rapid point-of-care testing: A single-arm clinical trial

Objective We aimed to assess the role of procalcitonin (PCT) to guide the initial selection of the antibiotic regimen for low-risk community-acquired pneumonia (CAP). Methods A single-arm clinical trial was conducted including outpatients with CAP and Pneumonia Severity Index risk classes I-II. Antimicrobial selection was based on the results of PCT measured with a rapid ...

Ethnicity and the first diagnosis of a wide range of cardiovascular diseases: Associations in a linked electronic health record cohort of 1 million patients

Background While the association of ethnic group with individual cardiovascular diseases has been studied, little is known about ethnic differences in the initial lifetime presentation of clinical cardiovascular disease in contemporary populations. Methods and results We studied 1,068,318 people, aged ≥30 years and free from diagnosed CVD at baseline (90.9% White, 3.6% South Asian ...

Unintentional weight loss: Clinical characteristics and outcomes in a prospective cohort of 2677 patients

Background Whereas there are numerous studies on unintentional weight loss (UWL), these have been limited by small sample sizes, short or variable follow‐up, and focus on older patients. Although some case series have revealed that malignancies escaping early detection and uncovered subsequently are exceptional, reported follow-ups have been too short or unspecified and necropsies ...

Environmental factors influencing the spatio-temporal distribution of Carybdea marsupialis (Lineo, 1978, Cubozoa) in South-Western Mediterranean coasts

ValparaÂõso, ValparaÂõso, Chile, 2 Marine Biology and Oceanography Department, Institut de Ciències del Mar, Consejo Superior de Investigaciones CientÂõficas , Barcelona , Spain , 3 Dipartimento di Scienze ... ( 15 mm) individuals. The Spanish Ministry of the Environment (DireccioÂn General de Sostenibilidad de la Costa y el Mar) and the regional environmental authority (DireccioÂn General del Agua) supported

Prediction of long-term outcomes of HIV-infected patients developing non-AIDS events using a multistate approach

13 / 16 Author Contributions Conceptualization: Mar MasiaÂ, Sergio Padilla, FeÂlix GutieÂrrez. Data curation: Mar MasiaÂ, Sergio Padilla, Santiago Moreno, Jose A. Iribarren, Jorge del Romero, Juan ... L. GoÂmez-Sirvent, MarÂõa Rivero, Francesc Vidal, Antonio A. Campins. Formal analysis: Mar MasiaÂ, Sergio Padilla, Xavier Barber, FeÂlix GutieÂrrez. Funding acquisition: Mar MasiaÂ, FeÂlix

Controlled delivery of tauroursodeoxycholic acid from biodegradable microspheres slows retinal degeneration and vision loss in P23H rats

Successful drug therapies for treating ocular diseases require effective concentrations of neuroprotective compounds maintained over time at the site of action. The purpose of this work was to assess the efficacy of intravitreal controlled delivery of tauroursodeoxycholic acid (TUDCA) encapsulated in poly(D,L-lactic-co-glycolic acid) (PLGA) microspheres for the treatment of the ...

Human metapnuemovirus infections in hospitalized children and comparison with other respiratory viruses. 2005-2014 prospective study

Background Human metapneumovirus (HMPV) has an important etiological role in acute lower respiratory infections in children under five years. Our objectives were to estimate the relative contribution of HMPV to hospitalization in children with acute respiratory infection, to define the clinical and epidemiological features of HMPV single and multiple infections, and to compare HMPV ...

KRAS and BRAF somatic mutations in colonic polyps and the risk of metachronous neoplasia

conflict of interest). Carla Guarinos and Mar Giner Calabuig received a predoctoral grant from Conselleria d'Educacio de la Generalitat Valenciana (VALi+d. EXP ACIF/2010/ 018, ACIF/2016/002) and Eva ... , Araceli GarcÂõa-MartÂõnez, Cristina Alenda, Mar Giner-Calabuig, Oscar Murcia, Carolina Mangas, Artemio PayaÂ, Jose R. Aparicio, Francisco A. Ruiz, Juan MartÂõnez, Juan A. Casellas, Jose L. Soto, Pedro

Aspergillus sydowii and Other Potential Fungal Pathogens in Gorgonian Octocorals of the Ecuadorian Pacific

(Corallium rubrum L.) . Mar Biol . 2006 ; 149 : 1059 ± 1070 . doi: 10 .1007/s00227-006- 0302-8 6. Gates RD , Ainsworth TD . The nature and taxonomic composition of coral symbiomes as drivers of performance ... limits in scleractinian corals . J Exp Mar Bio Ecol . Elsevier B.V. ; 2011 ; 408 : 94 ± 101 . doi: 10 . 1016/j.jembe. 2011 . 07 .029 7. NystroÈm M , Folke C , Moberg F. Coral reef disturbance and

Preclinical Immunomodulation by the Probiotic Bifidobacterium breve M-16V in Early Life

This study aimed to investigate the effect of supplementation with the probiotic Bifidobacterium breve M-16V on the maturation of the intestinal and circulating immune system during suckling. In order to achieve this purpose, neonatal Lewis rats were supplemented with the probiotic strain from the 6th to the 18th day of life. The animals were weighed during the study, and faecal ...

Executive Functioning in Men with Schizophrenia and Substance Use Disorders. Influence of Lifetime Suicide Attempts

Background Lifetime suicide attempts in patients with comorbidity between psychotic disorders and Substance Use Disorder (SUD), known as dual diagnosis, was associated with a worse clinical and cognitive state, poor prognosis and premature death. However, to date no previous study has examined the cognitive performance of these patients considering as independent the presence or ...

Traffic-related air pollution and spectacles use in schoolchildren

, China, 9 IMIM-Parc Salut Mar , Spain - OPEN ACCESS Funding: The research leading to these results has received funding from the European Research Council under the ERC Grant Agreement number 268479 ... and the BREATHE project was approved (No. 2010/41221/I) by the Clinical Research Ethical Committee of the Parc de Salut MAR, Barcelona, Spain. Outcome and covariate data We considered the use of

Differences in gut microbiota profile between women with active lifestyle and sedentary women

Physical exercise is a tool to prevent and treat some of the chronic diseases affecting the world’s population. A mechanism through which exercise could exert beneficial effects in the body is by provoking alterations to the gut microbiota, an environmental factor that in recent years has been associated with numerous chronic diseases. Here we show that physical exercise performed ...

Mixtures of Two Bile Alcohol Sulfates Function as a Proximity Pheromone in Sea Lamprey

Unique mixtures of pheromone components are commonly identified in insects, and have been shown to increase attractiveness towards conspecifics when reconstructed at the natural ratio released by the signaler. In previous field studies of pheromones that attract female sea lamprey (Petromyzon marinus, L.), putative components of the male-released mating pheromone included the newly ...

Bleeding Risk with Long-Term Low-Dose Aspirin: A Systematic Review of Observational Studies

Background Low-dose aspirin has proven effectiveness in secondary and primary prevention of cardiovascular events, but is also associated with an increased risk of major bleeding events. For primary prevention, this absolute risk must be carefully weighed against the benefits of aspirin; such assessments are currently limited by a lack of data from general populations. Methods ...

New Design for Rapid Prototyping of Digital Master Casts for Multiple Dental Implant Restorations

Aim This study proposes the replacement of all the physical devices used in the manufacturing of conventional prostheses through the use of digital tools, such as 3D scanners, CAD design software, 3D implants files, rapid prototyping machines or reverse engineering software, in order to develop laboratory work models from which to finish coatings for dental prostheses. Different ...