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Does the rising placebo response impact antihypertensive clinical trial outcomes? An analysis of data from the Food and Drug Administration 1990-2016

. Author Contributions Conceptualization: Arif Khan, Kaysee Fahl Mar, Walter A. Brown. Data curation: Kaysee Fahl Mar. 15 / 17 Formal analysis: Kaysee Fahl Mar. Investigation: Kaysee Fahl Mar ... . Methodology: Arif Khan, Kaysee Fahl Mar, Walter A. Brown. Project administration: Arif Khan. Supervision: Arif Khan, Joshua Schilling, Walter A. Brown. Validation: Arif Khan, Kaysee Fahl Mar, Joshua

Improving stability of prediction models based on correlated omics data by using network approaches

: Renaud Tissier, Mar RodrÂõguez-Girondo. Formal analysis: Renaud Tissier. 20 / 23 Methodology: Renaud Tissier. Software: Renaud Tissier. Supervision: Jeanine Houwing-Duistermaat, Mar RodrÂõguez-Girondo ... . Writing ± original draft: Renaud Tissier, Jeanine Houwing-Duistermaat, Mar RodrÂõguez Girondo. 21 / 23 22 / 23 1. RodrÂõguez-Girondo M. and Salo P. and Burzykowsky T. and Perola M. and Houwing-Duistermaat

Polyphenol estimated intake and dietary sources among older adults from Mallorca Island

polyphenol absorption by the body. Supporting information S1 Table. Food contributors table. (PDF) Author Contributions Conceptualization: Maria del Mar Bibiloni, Josep A. Tur. Data curation: Joanne Karam ... , Maria del Mar Bibiloni. Formal analysis: Joanne Karam, Maria del Mar Bibiloni. Funding acquisition: Josep A. Tur. Investigation: Joanne Karam, Maria del Mar Bibiloni. Project administration: Josep A

The clinical characteristics of adults with rheumatic heart disease in Yangon, Myanmar: An observational study

that surgery is out of the reach of almost every Myanmar citizen (personal communication, Professor Mar Mar Kyi). Although PBMV is less expensive (out-of-pocket expenses: USD1000) a benefit from this ... . Formal analysis: Josh Hanson. Investigation: Nan Phyu Sin Toe Myint, Ne Myo Aung, Myint Soe Win, Thu Ya Htut, Mar Mar Kyi. Methodology: Josh Hanson. Supervision: Ne Myo Aung, Myint Soe Win, David A

Identifying unmet clinical need in hypertrophic cardiomyopathy using national electronic health records

. Supplemental methods. (DOC) Author Contributions Conceptualization: Mar Pujades-Rodriguez, Oliver P. Guttmann, Perry Elliott, Harry Hemingway. Data curation: Mar Pujades-Rodriguez, Arturo Gonzalez-Izquierdo ... , Bram Duyx. Formal analysis: Mar Pujades-Rodriguez. Funding acquisition: Harry Hemingway. Methodology: Mar Pujades-Rodriguez, Oliver P. Guttmann. Project administration: Mar Pujades-Rodriguez

Decisional balance and processes of change in community-recruited with moderate-high versus mild severity of cannabis dependence

Albein-Urios. Formal analysis: Mã del Mar Rueda. The data collection and the field work were performed by the FQM356 research group as part Investigation: Francisca LoÂpez-Torrecillas, Eva MarÂõa LoÂpez

An optimization design proposal of automated guided vehicles for mixed type transportation in hospital environments

Aim The aim of this paper is to present an optimization proposal in the automated guided vehicles design used in hospital logistics, as well as to analyze the impact of its implementation in a real environment. Method This proposal is based on the design of those elements that would allow the vehicles to deliver an extra cart by the towing method. So, the proposal intention is to...

A user-friendly tool to evaluate the effectiveness of no-take marine reserves

Conceptualization: Juan Carlos Villaseñor-Derbez, Caio Faro, Melaina Wright, Jael MartÂõnez, Sean Fitzgerald, Stuart Fulton, Maria del Mar Mancha-Cisneros, Gavin McDonald, Fiorenza Micheli, Alvin SuaÂrez, Jorge Torre ... : Juan Carlos Villaseñor-Derbez, Caio Faro, Melaina Wright, Jael MartÂõnez, Christopher Costello. Methodology: Juan Carlos Villaseñor-Derbez, Caio Faro, Melaina Wright, Jael MartÂõnez, Maria del Mar

Trace element contents in toenails are related to regular physical activity in older adults

Conceptualization: Marcela Gonzalez-Gross, Josep A. Tur. Formal analysis: Maria del Mar Bibiloni. Funding acquisition: Antoni Pons. Investigation: Antoni Sureda, Maria del Mar Bibiloni, Alicia Julibert, Raquel ... Aparicio-Ugar riza, Gonzalo Palacios-Le BleÂ. Supervision: Josep A. Tur. Writing ± original draft: Antoni Sureda, Maria del Mar Bibiloni, Josep A. Tur. Writing ± review & editing: Antoni Sureda, Maria del

Screening for precancerous anal lesions with P16/Ki67 immunostaining in HIV-infected MSM

-Molina. Data curation: Sergio Serrano-Villar, Beatriz HernaÂndez-Novoa, Jorge del Romero, Antonio Ocampo, Jose RamoÂn Blanco, Mar MasiaÂ, Elena Sendagorta, Gonzalo Sanz, Jose A. PeÂrezMolina. Formal

Procalcitonin for selecting the antibiotic regimen in outpatients with low-risk community-acquired pneumonia using a rapid point-of-care testing: A single-arm clinical trial

Objective We aimed to assess the role of procalcitonin (PCT) to guide the initial selection of the antibiotic regimen for low-risk community-acquired pneumonia (CAP). Methods A single-arm clinical trial was conducted including outpatients with CAP and Pneumonia Severity Index risk classes I-II. Antimicrobial selection was based on the results of PCT measured with a rapid point-of...

Unintentional weight loss: Clinical characteristics and outcomes in a prospective cohort of 2677 patients

Background Whereas there are numerous studies on unintentional weight loss (UWL), these have been limited by small sample sizes, short or variable follow‐up, and focus on older patients. Although some case series have revealed that malignancies escaping early detection and uncovered subsequently are exceptional, reported follow-ups have been too short or unspecified and...

Ethnicity and the first diagnosis of a wide range of cardiovascular diseases: Associations in a linked electronic health record cohort of 1 million patients

Background While the association of ethnic group with individual cardiovascular diseases has been studied, little is known about ethnic differences in the initial lifetime presentation of clinical cardiovascular disease in contemporary populations. Methods and results We studied 1,068,318 people, aged ≥30 years and free from diagnosed CVD at baseline (90.9% White, 3.6% South...

Environmental factors influencing the spatio-temporal distribution of Carybdea marsupialis (Lineo, 1978, Cubozoa) in South-Western Mediterranean coasts

ValparaÂõso, ValparaÂõso, Chile, 2 Marine Biology and Oceanography Department, Institut de Ciències del Mar, Consejo Superior de Investigaciones CientÂõficas , Barcelona , Spain , 3 Dipartimento di Scienze ... ( 15 mm) individuals. The Spanish Ministry of the Environment (DireccioÂn General de Sostenibilidad de la Costa y el Mar) and the regional environmental authority (DireccioÂn General del Agua) supported

Prediction of long-term outcomes of HIV-infected patients developing non-AIDS events using a multistate approach

13 / 16 Author Contributions Conceptualization: Mar MasiaÂ, Sergio Padilla, FeÂlix GutieÂrrez. Data curation: Mar MasiaÂ, Sergio Padilla, Santiago Moreno, Jose A. Iribarren, Jorge del Romero, Juan ... L. GoÂmez-Sirvent, MarÂõa Rivero, Francesc Vidal, Antonio A. Campins. Formal analysis: Mar MasiaÂ, Sergio Padilla, Xavier Barber, FeÂlix GutieÂrrez. Funding acquisition: Mar MasiaÂ, FeÂlix

Human metapnuemovirus infections in hospitalized children and comparison with other respiratory viruses. 2005-2014 prospective study

Background Human metapneumovirus (HMPV) has an important etiological role in acute lower respiratory infections in children under five years. Our objectives were to estimate the relative contribution of HMPV to hospitalization in children with acute respiratory infection, to define the clinical and epidemiological features of HMPV single and multiple infections, and to compare...

High-permeability region size on perfusion CT predicts hemorrhagic transformation after intravenous thrombolysis in stroke

. Liebeskind, GoÈtz Thomalla, Bijoy K. Menon, Andrew Demchuk, Max Wintermark, Salvador Pedraza, Mar Castellanos. Data curation: Pepus Daunis-i-Estadella, Mar Castellanos. Formal analysis: Josep Puig, Gerard ... Blasco, Pepus Daunis-i-Estadella, Mar Castellanos. Funding acquisition: Mar Castellanos. Investigation: Josep Puig, MarÂõa Carrillo-GarcÂõa, Carlos Aboud, MarÂõa HernaÂndez-PeÂrez, JoaquÂõn Serena

Aspergillus sydowii and Other Potential Fungal Pathogens in Gorgonian Octocorals of the Ecuadorian Pacific

(Corallium rubrum L.) . Mar Biol . 2006 ; 149 : 1059 ± 1070 . doi: 10 .1007/s00227-006- 0302-8 6. Gates RD , Ainsworth TD . The nature and taxonomic composition of coral symbiomes as drivers of performance ... limits in scleractinian corals . J Exp Mar Bio Ecol . Elsevier B.V. ; 2011 ; 408 : 94 ± 101 . doi: 10 . 1016/j.jembe. 2011 . 07 .029 7. NystroÈm M , Folke C , Moberg F. Coral reef disturbance and

Controlled delivery of tauroursodeoxycholic acid from biodegradable microspheres slows retinal degeneration and vision loss in P23H rats

Successful drug therapies for treating ocular diseases require effective concentrations of neuroprotective compounds maintained over time at the site of action. The purpose of this work was to assess the efficacy of intravitreal controlled delivery of tauroursodeoxycholic acid (TUDCA) encapsulated in poly(D,L-lactic-co-glycolic acid) (PLGA) microspheres for the treatment of the...

Preclinical Immunomodulation by the Probiotic Bifidobacterium breve M-16V in Early Life

This study aimed to investigate the effect of supplementation with the probiotic Bifidobacterium breve M-16V on the maturation of the intestinal and circulating immune system during suckling. In order to achieve this purpose, neonatal Lewis rats were supplemented with the probiotic strain from the 6th to the 18th day of life. The animals were weighed during the study, and faecal...