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Preventing the Complications Associated with the Use of Dermal Fillers in Facial Aesthetic Procedures: An Expert Group Consensus Report

Background The use of dermal fillers in minimally invasive facial aesthetic procedures has become increasingly popular of late, yet as the indications and the number of procedures performed increase, the number of complications is also likely to increase. Paying special attention to specific patient characteristics and to the technique used can do much to avoid these complications. ...

Fitting the epidemiology and neuropathology of the early stages of Alzheimer’s disease to prevent dementia

. Clinicoecon Outcomes Res . 2011 ; 3 : 189 - 95 . 14. Mar J , Arrospide A , Comas M. Budget impact analysis of thrombolysis for stroke in Spain: a discrete event simulation model . Value Health . 2010 ; 13 : 69 ... population-based cohorts: Neurologic Diseases in the Elderly Research group . Neurology . 2000 ; 54 : S4 - 9 . 17. Karnon J , Stahl J , Brennan A , Caro JJ , Mar J , Möller J , et al. Modeling using discrete

Association between cell-bound blood amyloid-β(1 - 40) levels and hippocampus volume

Introduction The identification of early, preferably presymptomatic, biomarkers and true etiologic factors for Alzheimer’s disease (AD) is the first step toward establishing effective primary and secondary prevention programs. Consequently, the search for a relatively inexpensive and harmless biomarker for AD continues. Despite intensive research worldwide, to date there is no ...

Maternal Smoking During Pregnancy and Fetal Biometry: The INMA Mother and Child Cohort Study

J. Aurrekoetxea); Centre for Research of Environmental Epidemiology (CREAL), Barcelona, Spain (Martine Vrijheid, Mar lvarez-Pedrerol); and Municipal Institute of Medical Research (IMIM-Hospital del ... Mar), Barcelona, Spain (Martine Vrijheid, Mar lvarez-Pedrerol). This work was supported by grants from Instituto de Salud Carlos III (Red INMA G03/176, CB06/02/0041, FIS-FEDER 03/1615, 04/1509, 04/1112

Iodine Supplementation During Pregnancy and Infant Neuropsychological Development: INMA Mother and Child Cohort Study

, Spain (Mar lvarez-Pedrerol, Joan Forns, Jordi Julvez); Hospital del Mar Research Institute (IMIM), Barcelona, Spain (Mar lvarez-Pedrerol, Joan Forns, Jordi Julvez); Clinical Chemistry Unit, Public Health

Use of Epidemiology in Clinical Medical Publications, 1983–1999: A Citation Analysis

, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention , Atlanta, GA 2 Reprint requests to Dr. La Mar Hasbrouck, CDC-NCIPC , 4770 Buford Highway, NE, Mailstop K-60

Leprosy ulcers in a rural hospital of Ethiopia: pattern of aerobic bacterial isolates and drug sensitivities

Background Plantar ulcers, which commonly occur in leprosy patients, tend to recur increasing physical disability. The aim of this study is to identify both the bacteriological profile of these ulcers and the antibiotic susceptibility of the isolated bacteria. Materials and methods 68 leprosy patients with chronic ulcers attending the in-patient department of Gambo General ...

A fatal case of Nocardia otitidiscaviarum pulmonary infection and brain abscess: taxonomic characterization by molecular techniques

We report on a rare case of pulmonary Nocardiosis and brain abscess caused by Nocardia otitidiscaviarum in an elderly woman with chronic obstructive pulmonary disease. Taxonomic identification involved phenotypic testing, restriction fragment length polymorphism (RFLP), and complete 16S rRNA gene sequencing.

Menopausal symptoms in women undergoing chemotherapy-induced and natural menopause: a prospective controlled study

Background: Women with breast cancer frequently undergo menopause following adjuvant chemotherapy. Here, we investigated whether they have more severe symptoms than women undergoing natural menopause. Patients and methods: Forty-one women who had undergone menopause as a result of chemotherapy and 57 healthy women who had undergone recent natural menopause were evaluated on two ...

Identification and validation of uterine stimulant methylergometrine as a potential inhibitor of caspase-1 activation

Inflammasomes are intracellular multiprotein complexes of the innate immune system. Upon an inflammatory insult, such as infection or intracellular damage, a nucleotide-binding oligomerization domain-like receptor (NLR) sensor protein and the adaptor protein ASC (apoptosis-associated speck-like protein containing a caspase activation and recruitment domain) are assembled to ...

Comparison of the glidescope®, flexible fibreoptic intubating bronchoscope, iPhone modified bronchoscope, and the Macintosh laryngoscope in normal and difficult airways: a manikin study

manikin study Adrian Langley 0 Gabriel Mar Fan 0 0 Equal contributors Department of Anaesthesia and Pain Management, QE II Jubilee Hospital , Metro South HHN, Coopers Plain, QLD 4108 , Australia

NMR characterisation of the minimal interacting regions of centrosomal proteins 4.1R and NuMA1: effect of phosphorylation

Background Some functions of 4.1R in non-erythroid cells are directly related with its distinct sub-cellular localisation during cell cycle phases. During mitosis, 4.1R is implicated in cell cycle progression and spindle pole formation, and co-localizes with NuMA1. However, during interphase 4.1R is located in the nucleus and only partially co-localizes with NuMA1. Results We have ...

A Parzen window-based approach for the detection of locally enriched transcription factor binding sites

Background Identification of cis- and trans-acting factors regulating gene expression remains an important problem in biology. Bioinformatics analyses of regulatory regions are hampered by several difficulties. One is that binding sites for regulatory proteins are often not significantly over-represented in the set of DNA sequences of interest, because of high levels of false ...

Analysis of DNA strand-specific differential expression with high density tiling microarrays

Luis Quintales Mar Snchez 0 Francisco Antequera 0 0 Instituto de Microbiologia Bioquimica, Consejo Superior de Investigaciones Cientificas (CSIC)/Universidad de Salamanca , Edificio Departamental

KA-SB: from data integration to large scale reasoning

Background The analysis of information in the biological domain is usually focused on the analysis of data from single on-line data sources. Unfortunately, studying a biological process requires having access to disperse, heterogeneous, autonomous data sources. In this context, an analysis of the information is not possible without the integration of such data. Methods KA-SB is a ...

Data-driven normalization strategies for high-throughput quantitative RT-PCR

Background High-throughput real-time quantitative reverse transcriptase polymerase chain reaction (qPCR) is a widely used technique in experiments where expression patterns of genes are to be profiled. Current stage technology allows the acquisition of profiles for a moderate number of genes (50 to a few thousand), and this number continues to grow. The use of appropriate ...

Muscle cell identity requires Pax7-mediated lineage-specific DNA demethylation

Background Skeletal muscle stem cells enable the formation, growth, maintenance, and regeneration of skeletal muscle throughout life. The regeneration process is compromised in several pathological conditions, and muscle progenitors derived from pluripotent stem cells have been suggested as a potential therapeutic source for tissue replacement. DNA methylation is an important ...

Neuronal deletion of GSK3β increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2

Background In the adult central nervous system, axonal regeneration is abortive. Regulators of microtubule dynamics have emerged as attractive targets to promote axonal growth following injury as microtubule organization is pivotal for growth cone formation. In this study, we used conditioned neurons with high regenerative capacity to further dissect cytoskeletal mechanisms that ...