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(Kein) Namenswechsel

hat aber irgendwann tatsächlich seinen Nachnamen ändern lassen. Der Name des jungen Zahnarztes ließ wohl nur wenige Patienten schmunzeln: Er hieß „Kummer“. mar

A Comparison of RNA-Seq Results from Paired Formalin-Fixed Paraffin-Embedded and Fresh-Frozen Glioblastoma Tissue Samples

Sant Pau , Barcelona , Spain , 12 Pathology Department (Neuropathology), Hospital Clinic , Barcelona , Spain , 13 Pathology Department, Hospital del Mar , Barcelona , Spain , 14 Glioma and Neural Stem ... of participating institutions: Fundacio Institut Mar d'Investigacions Mèdiques, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Institut d'Investigacio en Ciències de la Salut

A Genetic Algorithm for the Bi-Level Topological Design of Local Area Networks

Local access networks (LAN) are commonly used as communication infrastructures which meet the demand of a set of users in the local environment. Usually these networks consist of several LAN segments connected by bridges. The topological LAN design bi-level problem consists on assigning users to clusters and the union of clusters by bridges in order to obtain a minimum response ...

A Glycolipid Adjuvant, 7DW8-5, Enhances CD8+ T Cell Responses Induced by an Adenovirus-Vectored Malaria Vaccine in Non-Human Primates

A key strategy to a successful vaccine against malaria is to identify and develop new adjuvants that can enhance T-cell responses and improve protective immunity. Upon co-administration with a rodent malaria vaccine in mice, 7DW8-5, a recently identified novel analog of α-galactosylceramide (α-GalCer), enhances the level of malaria-specific protective immune responses more strongly ...

A Large Multicenter Study of Methicillin–Susceptible and Methicillin–Resistant Staphylococcus aureus Prosthetic Joint Infections Managed With Implant Retention

, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona , Barcelona 15 Department of Internal Medicine and Infectious Diseases, Hospital del Mar 16 Department of Infectious Diseases, Hospital ... Mar, Barcelona, Spain); Mara Franco, Marcos Jordn and Pere Coll (Hospital de la Santa Creu i Sant Pau, Barcelona, Spain); Juan Amador-Mellado, Carlos Fuster-Foz, Luis Garca-Pano (Hospital El Bierzo

A Method for the Generation of Ectromelia Virus (ECTV) Recombinants: In Vivo Analysis of ECTV vCD30 Deletion Mutants

Background Ectromelia virus (ECTV) is the causative agent of mousepox, a lethal disease of mice with similarities to human smallpox. Mousepox progression involves replication at the initial site of infection, usually the skin, followed by a rapid spread to the secondary replicative organs, spleen and liver, and finally a dissemination to the skin, where the typical rash associated ...

A Nanoconjugate Apaf-1 Inhibitor Protects Mesothelial Cells from Cytokine-Induced Injury

Background Inflammation may lead to tissue injury. We have studied the modulation of inflammatory milieu-induced tissue injury, as exemplified by the mesothelium. Peritoneal dialysis is complicated by peritonitis episodes that cause loss of mesothelium. Proinflammatory cytokines are increased in the peritoneal cavity during peritonitis episodes. However there is scarce information ...

A Novel Model of Human Skin Pressure Ulcers in Mice

Introduction Pressure ulcers are a prevalent health problem in today's society. The shortage of suitable animal models limits our understanding and our ability to develop new therapies. This study aims to report on the development of a novel and reproducible human skin pressure ulcer model in mice. Material and Methods Male non-obese, diabetic, severe combined immunodeficiency mice ...

A Parzen window-based approach for the detection of locally enriched transcription factor binding sites

Background Identification of cis- and trans-acting factors regulating gene expression remains an important problem in biology. Bioinformatics analyses of regulatory regions are hampered by several difficulties. One is that binding sites for regulatory proteins are often not significantly over-represented in the set of DNA sequences of interest, because of high levels of false ...

A Polymeric Nanomedicine Diminishes Inflammatory Events in Renal Tubular Cells

The polyglutamic acid/peptoid 1 (QM56) nanoconjugate inhibits apoptosis by interfering with Apaf-1 binding to procaspase-9. We now describe anti-inflammatory properties of QM56 in mouse kidney and renal cell models. In cultured murine tubular cells, QM56 inhibited the inflammatory response to Tweak, a non-apoptotic stimulus. Tweak induced MCP-1 and Rantes synthesis through JAK2 ...

A Prospective Evaluation of Missed Injuries in Trauma Patients, Before and After Formalising the Trauma Tertiary Survey

Objective This study prospectively evaluated in-hospital and postdischarge missed injury rates in admitted trauma patients, before and after the formalisation of a trauma tertiary survey (TTS) procedure. Methods Prospective before-and-after cohort study. TTS were formalised in a single regional level II trauma hospital in November 2009. All multitrauma patients admitted between ...

A Rosemary Extract Rich in Carnosic Acid Selectively Modulates Caecum Microbiota and Inhibits β-Glucosidase Activity, Altering Fiber and Short Chain Fatty Acids Fecal Excretion in Lean and Obese Female Rats

Background Carnosic acid (CA) and rosemary extracts (RE) show body-weight, energy metabolism and inflammation regulatory properties in animal models but the mechanisms are not yet understood. Gut microbiota plays an important role in the host metabolism and inflammatory status and is modulated by the diet. The aim of this research was to investigate whether a RE enriched in CA ...

A census of yeast protein-protein interactions

Genome-wide yeast two-hybrid screening has provided a census of protein-protein interactions in Saccharomyces cerevisiae.

A conserved role of the RSC chromatin remodeler in the establishment of nucleosome-depleted regions

The occupancy of nucleosomes governs access to the eukaryotic genomes and results from a combination of biophysical features and the effect of ATP-dependent remodelling complexes. Most promoter regions show a conserved pattern characterized by a nucleosome-depleted region (NDR) flanked by nucleosomal arrays. The conserved RSC remodeler was reported to be critical to establish NDR ...

A fatal case of Nocardia otitidiscaviarum pulmonary infection and brain abscess: taxonomic characterization by molecular techniques

We report on a rare case of pulmonary Nocardiosis and brain abscess caused by Nocardia otitidiscaviarum in an elderly woman with chronic obstructive pulmonary disease. Taxonomic identification involved phenotypic testing, restriction fragment length polymorphism (RFLP), and complete 16S rRNA gene sequencing.

A guide to performing a peer review of randomised controlled trials

that only emerges after a detailed read or © 2015 Del Mar and Hoffmann. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http

A literature review and case report of hand, foot and mouth disease in an immunocompetent adult

Background To report an uncommon case of hand, foot and mouth disease, (HFMD) in an immunocompetent adult; a highly infectious disease, characterized by the appearance of vesicles on the mouth, hands and feet, associated with coxsackieviruses and enteroviruses; including a literature review. Case report A 23 year Caucasian male with no medical or surgical history, no allergies, was ...

A one step real-time RT-PCR assay for the quantitation of Wheat yellow mosaic virus (WYMV)

-time PCR . J Virol Methods 2010 , 169 : 416 - 419 . 24. Zhang P , Mar T , Liu W , Li L , Wang X : Simultaneous detection and differentiation of Rice black streaked dwarf virus (RBSDV) and Southern rice

A quality assessment of genetic association studies supporting susceptibility and outcome in acute lung injury

Introduction Clinical observations and animal models provide evidence that the development of acute lung injury (ALI), a phenomenon of acute diffuse lung inflammation in critically ill patients, is influenced by genetic factors. Association studies are the main tool for exploring common genetic variations underlying ALI susceptibility and/or outcome. We aimed to assess the quality ...