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Prelingual Deafness: High Prevalence of a 30delG Mutation in the Connexin 26 Gene

cosegregation between deafness and polymorphic markers of the DFNB1 region, with maximum individual lod scores ranging from 0.6 to 1.2. Ten other families in the original study of Maw et al. (8) had shown no

Linkage of Blepharophimosis Syndrome in a Large Indian Pedigree to Chromosome 7p

Blepharophimosis syndrome (BPES) is an autosomal dominant disorder involving abnormal eyelid development. Cytogenetic and linkage analyses have previously implicated the chromosome 3q23 region in multiple cases of this syndrome. However, in a few cases cytogenetic analyses have implicated other chromosomal regions in this condition. Here we report linkage of BPES in a large...

Solid-Phase Extraction in Amphetamine and Methamphetamine Analysis of Urine

, Taipei , Taiwan(R.O.C.) 1 J&W Scientific , 91 Blue RavineRoad, Folsom, California , USA 2 Maw-Rong Lee 3 , Sheng-Chien Yu, Ching-Lin tin, and Yao-Chia Yeh Department of Chemistry National Chung-Hsing

Successful pregnancy following blastocyst cryopreservation using super-cooling ultra-rapid vitrification

BACKGROUND: Blastocysts were cryopreserved by a new two-step ultra-rapid cooling in super-cooled liquid nitrogen (−205°C). METHODS: There were 308 mouse blastocysts collected from fertile B6CBF1 mice and 249 human blastocysts collected from 51 couples treated with IVF. The blastocysts were super-cooled by a Vit-Master™ and cryoloops after treatment in 50 and 100% vitrification...

Conserved RY-Repeats Mediate Transactivation of Seed-Specific Promoters by the Developmental Regulator PvALF

Andrew J. Bobb 0 Maw-Shenq Chern 0 Mauricio M. Bustos 0 0 Department of Biological Sciences, University of Maryland Baltimore County , 1000 Hilltop Circle, Baltimore, MD 21250, USA Transcription of

Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons

Parkinson's disease (PD) is characterized by the selective and progressive loss of dopaminergic (DA) neurons in the midbrain substantia nigra. Currently, available treatment is unable to alter PD progression. Previously, we demonstrated that valproic acid (VPA), a mood stabilizer, anticonvulsant and histone deacetylase (HDAC) inhibitor, increases the expression of glial cell line...

Low-Power Embedded DSP Core for Communication Systems

and 2003. He joined VIA Technologies, Inc., Taipei, Taiwan, right after his master course. His research interests include high-speed, low-power digital integrated circuits design and DSP system. Maw

Serum anti-müllerian hormone and estradiol levels as predictors of ovarian hyperstimulation syndrome in assisted reproduction technology cycles

BACKGROUND Anti-Müllerian hormone (AMH) is reported to be a reliable marker of the ovarian response to controlled ovarian stimulation (COS). The objective of this study is to determine whether the serum AMH level can predict ovarian hyperstimulation syndrome (OHSS) prior to selection of COS protocols. METHODS A cohort of 262 IVF cycles was investigated prospectively, in order to...

Modulation of energy deficiency in Huntington's disease via activation of the peroxisome proliferator-activated receptor gamma

Huntington's disease (HD) is a neurodegenerative disease caused by the expansion of a CAG trinucleotide repeat in exon 1 of the huntingtin (HTT) gene. Here, we report that the transcript of the peroxisome proliferator-activated receptor-γ (PPARγ), a transcription factor that is critical for energy homeostasis, was markedly downregulated in multiple tissues of a mouse model (R6/2...

Magnetic-activated cell sorting for sperm preparation reduces spermatozoa with apoptotic markers and improves the acrosome reaction in couples with unexplained infertility†

BACKGROUND Couples with unexplained infertility (UI) tend to have low fertilization rates with current IVF procedures. Here, we attempted to identify spermatozoa with apoptotic markers in couples with UI and unsuccessful intrauterine insemination (IUI) and we investigated the efficiency and benefit of magnetic-activated cell sorting (MACS) for sperm preparation in such patients...

Granzyme G is expressed in the two-cell stage mouse embryo and is required for the maternal-zygotic transition

Background Detailed knowledge of the molecular and cellular mechanisms that direct spatial and temporal gene expression in pre-implantation embryos is critical for understanding the control of the maternal-zygotic transition and cell differentiation in early embryonic development. In this study, twenty-three clones, expressed at different stages of early mouse development, were...

Longitudinal Analysis of Serological Responses of Adults to Helicobacter pylori Antigens

Because Helicobacter pylori persist for decades in the human stomach, the aim of this study was to examine the long-term course of H. pylori-specific serum immunoglobulin G (IgG) responses with respect to subclass and antigenic target. We studied paired serum samples obtained in 1973 and in 1994 in Vammala, Finland, from 64 healthy H. pylori-positive adults and from other healthy...

Impact of female age and male infertility on ovarian reserve markers to predict outcome of assisted reproduction technology cycles

Background This study was designed to assess the capability of ovarian reserve markers, including baseline FSH levels, baseline anti-Müllerian hormone (AMH) levels, and antral follicle count (AFC), as predictors of live births during IVF cycles, especially for infertile couples with advanced maternal age and/or male factors. Methods A prospective cohort of 336 first IVF/ICSI...

Mechanisms underlying Actinobacillus pleuropneumoniae exotoxin ApxI induced expression of IL-1β, IL-8 and TNF-α in porcine alveolar macrophages

Actinobacillus pleuropneumoniae (A. pleuropneumoniae) causes fibrino-hemorrhagic necrotizing pleuropneumonia in pigs. Production of proinflammatory mediators in the lungs is an important feature of A. pleuropneumoniae infection. However, bacterial components other than lipopolysaccharide involved in this process remain unidentified. The goals of this study were to determine the...

Long-term survival in a patient with repeated resections for lung metastasis after hepatectomy for ruptured hepatocellular carcinoma: a case report

Introduction Tumor rupture and pulmonary metastasis in patients with hepatocellular carcinoma are both associated with poor prognosis and treatment strategies are controversial. Case presentation Here we report a 50-year-old man with survival of over 90 months after undergoing an extended right lobectomy for a ruptured hepatocellular carcinoma and then repeated resections for...