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Inhibitory effects of HNF4α on migration/maltransformation of hepatic progenitors: HNF4α-overexpressing hepatic progenitors for liver repopulation

Background Although they are expandable in vitro, hepatic progenitors are immature cells and share many immunomarkers with hepatocellular carcinoma, raising potential concerns regarding maltransformation after transplantation. This study investigated the effects of hepatic nuclear factor (HNF) 4α on the proliferation, migration, and maltransformation of hepatic progenitors and ...

The neglected burden of snakebites in Cameroon: a review of the epidemiology, management and public health challenges

Objectives Snakebite is an underestimated medical and surgical emergency in developing countries responsible for a high disease burden. Optimal management of snake envenomation in these resource-limited settings is precluded by several public health challenges. In this review, we discuss the disease burden of snakebites in Cameroon and the public health challenges of its management ...

A New Smart Surface-Enhanced Raman Scattering Sensor Based on pH-Responsive Polyacryloyl Hydrazine Capped Ag Nanoparticles

A novel pH-responsive Ag@polyacryloyl hydrazide (Ag@PAH) nanoparticle for the first time as a surface-enhanced Raman scattering (SERS) substrate was prepared without reducing agent and end-capping reagent. Ag@PAH nanoparticles exhibited an excellent tunable detecting performance in the range from pH = 4 to pH = 9. This is explained that the swelling-shrinking behavior of responsive ...

Light Chain (AL) Amyloidosis: The Journey to Diagnosis

Background Light chain (AL) amyloidosis is a rare, complex disease associated with significant morbidity and mortality. Delays in diagnosis are common and may have detrimental consequences on patients’ prognosis. Too little is known regarding the patient journey to diagnosis. Objective The objective of this study was to describe the patient-reported journey to a correct diagnosis ...

Th17 cells are associated with protection from ventilator associated pneumonia

Background CD4+ T-helper 17 (Th17) cells and Interleukin (IL)-17A play an important role in clearing pathogens in mouse models of pneumonia. We hypothesized that numbers of Th17 cells and levels of IL-17A are associated with risk for nosocomial pneumonia in humans. Methods We collected bronchoalveolar lavage (BAL) fluid from mechanically ventilated (n = 25) patients undergoing ...

The advantage of being slow: The quasi-neutral contact process

According to the competitive exclusion principle, in a finite ecosystem, extinction occurs naturally when two or more species compete for the same resources. An important question that arises is: when coexistence is not possible, which mechanisms confer an advantage to a given species against the other(s)? In general, it is expected that the species with the higher ...

A graph exploration method for identifying influential spreaders in complex networks

The problem of identifying the influential spreaders - the important nodes - in a real world network is of high importance due to its theoretical interest as well as its practical applications, such as the acceleration of information diffusion, the control of the spread of a disease and the improvement of the resilience of networks to external attacks. In this paper, we propose a ...

Longitudinal strain assessed by cardiac magnetic resonance correlates to hemodynamic findings in patients with severe aortic stenosis and predicts positive remodeling after transcatheter aortic valve replacement

Aims To assess left-ventricular strain parameters before and after transcatheter aortic valve replacement (TAVR) by feature tracking cardiac magnetic resonance imaging (FT CMR) and to correlate the findings to hemodynamic state and left-ventricular remodeling. Methods and results Patients with symptomatic AS underwent FT CMR before and after TAVR. Patients were carefully evaluated ...

Water properties in pâtés enriched with potato juice

Freshly squeezed potato juice was used in the traditional European folk medicine. Potato juice can be introduced into food products both in its fresh as well as in thermally preserved form as a component of functional food. An attempt was made to analyse the impact of potato juice supplementation on qualitative and quantitative parameters characterising water bonds in poultry meat ...

Molecular characterization and multi-locus genotypes of Enterocytozoon bieneusi from captive red kangaroos (Macropus Rfus) in Jiangsu province, China

Enterocytozoon bieneusi is the most common pathogen of microsporidian species infecting humans worldwide. Although E. bieneusi has been found in a variety of animal hosts, information on the presence of E. bieneusi in captive kangaroos in China is limited. The present study was aimed at determining the occurrence and genetic diversity of E. bieneusi in captive kangaroos. A total of ...

The use of 18F-Fluoro-deoxy-glucose positron emission tomography (18F-FDG PET) as a non-invasive pharmacodynamic biomarker to determine the minimally pharmacologically active dose of AZD8835, a novel PI3Kα inhibitor

Background The phosphatidyl inositol 3 kinase (PI3K), AKT and mammalian target of rapamycin (mTOR) signal transduction pathway is frequently de-regulated and activated in human cancer and is an important therapeutic target. AZD8835 is a PI3K inhibitor, with selectivity against PI3K α and δ isoforms, which is currently in Phase 1 clinical trials. 18F-Fluoro-deoxy-glucose positron ...

Illness perception, diabetes knowledge and self-care practices among type-2 diabetes patients: a cross-sectional study

Background Self-care practices among persons living with type-2 diabetes are very crucial in diabetes manages as poor self-care results in complications. However, little research exists within the Ghanaian context. This study examined whether type-2 diabetes patients’ illness perception and diabetes knowledge significantly predict diabetes self-care practices. Methods A ...

Low-dose tolvaptan PK/PD: comparison of patients with hyponatremia due to syndrome of inappropriate antidiuretic hormone secretion to healthy adults

Purpose Tolvaptan (TLV) is indicated to treat hyponatremia due to syndrome of inappropriate diuretic hormone (SIADH) in Europe. Treatment is to be initiated at 15 mg QD but post-approval reporting indicates increasing use of 7.5 mg as the starting dose. Physicians believe 7.5 mg is effective and has a lower incidence of overly rapid correction of serum sodium. Methods Single TLV ...

Revisiting clinico-epidemiological pattern of human rickettsial infections in the central region of Sri Lanka: a hospital based descriptive study

Background This study revisits the clinico-epidemiology and serological patterns of rickettsioses in the central region of Sri Lanka and highlights the need of advanced diagnostics for precise identification of species responsible for rickettsioses. Methods The patients treated for rickettsioses between November 2009 and October 2011 were recruited for the study from Teaching ...

Alpha-synuclein oligomers: a new hope

Alpha-synuclein is a protein implicated in Parkinson’s disease and thought to be one of the main pathological drivers in the disease, although it remains unclear how this protein elicits its neurotoxic effects. Recent findings indicate that the assembly of toxic oligomeric species of alpha-synuclein may be one of the key processes for the pathology and spread of the disease. The ...

Women’s Preferences for Men’s Facial Masculinity: Trade-Off Accounts Revisited

Studies on mate preferences have demonstrated that women’s perception of male attractiveness is sensitive to men’s facial masculinity, and that women’s preferences for facial masculinity are subject to individual differences, such as own condition. These individual differences have been linked to potential trade-offs that women face given the hypothesized benefits and costs that ...

Obliquely Deposited Gold Nanohelices on Lithography-Free Prepared Nanoseeded Surfaces

A substrate surface on which gold particles are distributed is prepared by annealing an ultra-thin gold film to enable glancing angle deposition. By cooling the substrate and controlling its spin rate, two spiral-like and one screw-like gold nanohelix arrays are grown upon the seeded surfaces. The mean helix radius and pitch length are reduced to 17 and 55 nm, respectively. The ...

A comparison of the gender-specificity of age of consent legislation in Europe and China: Towards a gender-neutral age of consent in China?

Age of consent—the age at which young people are considered legally competent to consent to sexual activities—is an important weapon invented by law makers to protect young children from being sexually abused and exploited by predatory adults. In this study, a comparison of the age of consent legislation in 2004 and 2016 in Europe reveals that it is a trend for European law makers ...