Netherlands Heart Journal

http://link.springer.com/journal/12471

List of Papers (Total 932)

The Netherlands Arrhythmogenic Cardiomyopathy Registry: design and status update

BackgroundClinical research on arrhythmogenic cardiomyopathy (ACM) is typically limited by small patient numbers, retrospective study designs, and inconsistent definitions.AimTo create a large national ACM patient cohort with a vast amount of uniformly collected high-quality data that is readily available for future research.MethodsThis is a multicentre, longitudinal...

Questionnaire survey on cardiologists’ view and management of coronary microvascular disease in clinical practice

ObjectiveWe aimed to assess the opinion of Dutch cardiologists on coronary microvascular disease (CMD) and its management in clinical practice, and to assess the need for a CMD guideline among Dutch cardiologists.MethodsWe developed an online questionnaire including different aspects of CMD which was reviewed by an expert panel. The questionnaire was distributed by e‑mail among...

Association between cardiovascular disease and a history of cancer in patients with chest pain on the fast track outpatient clinic

BackgroundThe purpose of this study is to investigate the prevalence of a history of malignancy in patients with chest pain who were referred for computed tomography angiography as well as the long-term survival and cardiovascular outcomes, including coronary artery disease (CAD) and coronary artery calcium (CAC) percentiles of cancer survivors. These data are relevant since it...

Idiopathic atrial fibrillation patients rapidly outgrow their low thromboembolic risk: a 10-year follow-up study

BackgroundHealthy atrial fibrillation (AF) patients will eventually outgrow their low thromboembolic risk. The purpose of this study is to compare the development of cardiovascular disease in healthy AF patients as compared to healthy sinus rhythm patients and to assess appropriate anticoagulation treatment.MethodsForty-one idiopathic paroxysmal AF patients (56 ± 10 years, 66...

Inappropriate non-vitamin K antagonist oral anticoagulants prescriptions: be cautious with dose reductions

BackgroundNon-vitamin K antagonist oral anticoagulants (NOACs) are prescribed to patients with atrial fibrillation (AF) to reduce the risk of stroke. Prescribing the correct dose warrants careful consideration of the prevailing dose criteria that differ per NOAC. Electronic systems are useful to intercept prescriptions that are incorrect based on simple ‘primary’ criteria, for...

Incidence, angiographic and clinical predictors, and impact of stent thrombosis: a 6-year survey of 6,545 consecutive patients

ObjectiveWe sought to determine the incidence, angiographic predictors, and impact of stent thrombosis (ST).BackgroundGiven the high mortality after ST, this study emphasises the importance of ongoing efforts to identify angiographic predictors of ST.MethodsAll consecutive patients with angiographically confirmed ST between 2010 and 2016 were 1:4 matched for (1) percutaneous...

Large next-generation sequencing gene panels in genetic heart disease: challenges in clinical practice

BackgroundNext-generation sequencing gene panels are increasingly used for genetic diagnosis in inherited cardiac diseases. Besides pathogenic variants, multiple variants, variants of uncertain significance (VUS) and incidental findings can be detected. Such test results can be challenging for counselling and clinical decision making.MethodsWe present patient cases to illustrate...

Large next-generation sequencing gene panels in genetic heart disease: yield of pathogenic variants and variants of unknown significance

BackgroundGenetic heterogeneity is common in inherited cardiac diseases. Next-generation sequencing gene panels are therefore suitable for genetic diagnosis. We describe the results of implementation of cardiomyopathy and arrhythmia gene panels in clinical care.MethodsWe present detection rates for variants with unknown (class 3), likely (class 4), and certain (class 5...

Cardiology fellows-in-training are exposed to relatively high levels of radiation in the cath lab compared with staff interventional cardiologists—insights from the RECAP trial

BackgroundInterventional cardiologists are inevitably exposed to low-dose radiation, and consequently are at risk for radiation induced diseases like cataract and left-sided brain tumours. Operator behaviour may possibly be the largest influencer on radiation exposure. We hypothesised that awareness regarding radiation exposure grows as skill and the general experience in the...

Phospholamban cardiomyopathy: a Canadian perspective on a unique population

IntroductionPhospholamban cardiomyopathy is an inherited cardiomyopathy, characterised by a defect in regulation of the sarcoplasmic reticulum Ca2+ pump, often presenting with malignant arrhythmias and progressive cardiac dysfunction occurring at a young age.MethodsPhospholamban R14del mutation carriers and family members were identified from inherited arrhythmia clinics at 13...

Frailty score for elderly patients is associated with short-term clinical outcomes in patients with ST-segment elevated myocardial infarction treated with primary percutaneous coronary intervention

ObjectiveConsistent with the aging population in the Western world, there is a growing number of elderly patients with ST-segment elevation myocardial infarction (STEMI). Primary percutaneous coronary intervention (PCI) is the recommended reperfusion strategy in elderly patients; risk models to determine which of these patients are prone to have poor clinical outcomes are...

A randomised, investigator-initiated, clinical trial of the effects of fentanyl on P2Y12-receptor inhibition in patients with ST-elevation myocardial infarction who are pre-treated with crushed ticagrelor: rationale and design of the Opioids aNd crushed Ticagrelor In Myocardial infarction Evaluation (ON-TIME 3) trial

BackgroundFast and accurate platelet inhibition is an important therapeutic goal in the acute treatment of patients with ST-elevation myocardial infarction (STEMI). Platelet inhibitory effects induced by oral P2Y12-receptor antagonists are delayed in STEMI patients undergoing primary percutaneous coronary intervention (PCI) due to haemodynamic changes and delayed gastro...

Extra energy for hearts with a genetic defect: ENERGY trial

AimsPrevious studies have shown that hypertrophic cardiomyopathy mutation carriers have a decreased myocardial energy efficiency, which is thought to play a key role in the pathomechanism of hypertrophic cardiomyopathy (HCM). The ENERGY trial aims to determine whether metabolic drugs correct decreased myocardial energy efficiency in HCM mutation carriers at an early disease stage...

Adults with congenital heart disease: ready for mobile health?

PurposeMobile health (mHealth) could improve the outcome of grown-up patients with congenital heart disease (GUCH) and reduce their emergency care utilisation. Inappropriate use of mHealth, however, can lead to data overload for professionals and unnecessary data collection for patients, increasing the burden for both. We aimed to determine the clinical characteristics of...

Multidisciplinary decision-making in mitral valve disease: the mitral valve heart team

BackgroundAlthough decision-making using the heart-team approach is apparently intuitive and has a class I recommendation in most recent guidelines, supportive data is still lacking. The current study aims to demonstrate the individualised clinical pathway for mitral valve disease patients and to evaluate the outcome of all patients referred to the dedicated mitral valve heart...