Diabetes

http://diabetes.diabetesjournals.org

List of Papers (Total 7,067)

Genetic Contribution to the Divergence in Type 1 Diabetes Risk Between Children From the General Population and Children From Affected Families

The risk for autoimmunity and subsequently type 1 diabetes is 10-fold higher in children with a first-degree family history of type 1 diabetes (FDR children) than in children in the general population (GP children). We analyzed children with high-risk HLA genotypes ( n = 4,573) in the longitudinal TEDDY birth cohort to determine how much of the divergent risk is attributable to...

Endoplasmic Reticulum–Associated Degradation (ERAD) Has a Critical Role in Supporting Glucose-Stimulated Insulin Secretion in Pancreatic β-Cells

The molecular underpinnings of β-cell dysfunction and death leading to diabetes are not fully elucidated. The objective of the current study was to investigate the role of endoplasmic reticulum–associated degradation (ERAD) in pancreatic β-cells. Chemically induced ERAD deficiency in the rat insulinoma cell line INS-1 markedly reduced glucose-stimulated insulin secretion (GSIS...

Diabetes Takes New Steps to Increase Transparency and Reproducibility

Experimental reproducibility represents an essential component of scientific discourse. To ensure the integrity of the scientific process, we must ensure the ability to accurately replicate studies and to corroborate experimental results. Diabetes seeks to enhance the transparency, trust, and reproducibility of research reported in the journal. To support this effort, the journal...

Genome-Wide Association Study Confirming a Strong Effect of HLA and Identifying Variants in CSAD/lnc-ITGB7-1 on Chromosome 12q13.13 Associated With Susceptibility to Fulminant Type 1 Diabetes

The first genome-wide association study of fulminant type 1 diabetes was performed in Japanese individuals. As previously reported using a candidate gene approach, a strong association was observed with multiple single nucleotide polymorphisms (SNPs) in the HLA region, and the strongest association was observed with rs9268853 in the class II DR region ( P = 1.56 × 10−23, odds...

FoxO Transcription Factors Are Critical Regulators of Diabetes-Related Muscle Atrophy

Insulin deficiency and uncontrolled diabetes lead to a catabolic state with decreased muscle strength, contributing to disease-related morbidity. FoxO transcription factors are suppressed by insulin and thus are key mediators of insulin action. To study their role in diabetic muscle wasting, we created mice with muscle-specific triple knockout of FoxO1/3/4 and induced diabetes in...

Leveraging Genetics to Improve Cardiovascular Health in Diabetes: The 2018 Edwin Bierman Award Lecture

The past decade has witnessed an exponential increase in our ability to search the genome for genetic factors predisposing to cardiovascular disease (CVD) and in particular coronary heart disease (CHD). Identifying these genes could lead to the development of innovative strategies to prevent the cardiovascular complications of diabetes by allowing us to 1 ) create predictive...

Statement of Retraction. Matilde Caruso, Claudia Miele, Andrea Oliva, Gerolama Condorelli, Francesco Oriente, Gabriele Riccardi, Brunella Capaldo, Francesca Fiory, Domenico Accili, Pietro Formisano, and Francesco Beguinot. The IR1152 Mutant Insulin Receptor Selectively Impairs Insulin Action in Skeletal Muscle but Not in Liver. Diabetes 2000;49:1194–1202. DOI: 10.2337/diabetes.49.7.1194. PMID: 10909978

The above-cited article has been retracted by the American Diabetes Association (ADA), the publisher of Diabetes . This article was previously the subject of an expression of concern in the February 2018 issue of the journal (Diabetes 2018;67:345. DOI: 10.2337/db17-ec2017a. PMID: 29109243). On November 6, 2017, ADA contacted the corresponding author’s institution, Universit...

Targeting the CDA1/CDA1BP1 Axis Retards Renal Fibrosis in Experimental Diabetic Nephropathy

Targeting cell division autoantigen 1 (CDA1) is postulated to attenuate the profibrotic actions of transforming growth factor-β in diabetic nephropathy. This study has identified a regulatory protein for CDA1 and has then used genetic and pharmacological approaches to test in vivo whether strategies to target this pathway would lead to reduced renal injury. A novel protein, named...

A Network Analysis of Biomarkers for Type 2 Diabetes

Numerous studies have investigated individual biomarkers in relation to risk of type 2 diabetes. However, few have considered the interconnectivity of these biomarkers in the etiology of diabetes as well as the potential changes in the biomarker correlation network during diabetes development. We conducted a secondary analysis of 27 plasma biomarkers representing glucose...

In Pursuit of a Biomarker of Weight Gain Susceptibility—Is FGF21 a Candidate?

In our westernized obesogenic environment plagued by an overabundance of calorie-dense food and physical inactivity, obesity has become a highly prevalent condition and a major concern to public health. Interestingly, the predisposition for weight gain varies among people despite similar environmental exposures or familial traits (1). While eating less and moving more are obvious...

Mitochondrial Stability in Diabetic Retinopathy: Lessons Learned From Epigenetics

Diabetic retinopathy remains the leading cause of acquired blindness in working-age adults. While the cutting-edge research in the field has identified many molecular, functional, and structural abnormalities, the exact molecular mechanism of this devastating disease remains obscure. Diabetic environment drives dysfunction of the power generator of the cell and disturbs the...

A Call for Improved Reporting of Human Islet Characteristics in Research Articles

The increased availability of isolated human islets for diabetes research and the implementation of islet distribution programs in several countries worldwide have been driving forces behind the rapidly expanding number of scientific reports on studies using human islets. In Diabetologia , Hart and Powers (1) not only review the progress made in human islet research, made...

Insulin-Like Growth Factor Binding Protein 2 (IGFBP-2) and the Risk of Developing Type 2 Diabetes

Recent studies suggest that insulin-like growth factor binding protein 2 (IGFBP-2) may protect against type 2 diabetes, but population-based human studies are scarce. We aimed to investigate the prospective association of circulating IGFBP-2 concentrations and of differential methylation in the IGFBP-2 gene with type 2 diabetes risk.

Glucagon-Like Peptide 1 in the Brain: Where Is It Coming From, Where Is It Going?

Glucagon-like peptide 1 (GLP-1) is likely best known by many readers of Diabetes because of the role it plays in insulin secretion. Indeed, GLP-1 receptor (GLP-1R) agonists have become important tools for glycemic control in the treatment of type 2 diabetes. In addition to its incretin effects, GLP-1 signaling plays a role in the control of feeding (1) and other motivated...

Comment on Bu et al. Insulin Regulates Lipolysis and Fat Mass by Upregulating Growth/Differentiation Factor 3 in Adipose Tissue Macrophages. Diabetes 2018;67:1761–1772

In a recent article, Bu et al. (1) claim to describe a novel role for growth/differentiation factor 3 (GDF3) and the activin receptor–like kinase 7 (ALK7) in the regulation of adipose tissue lipolysis by insulin. It is an intriguing observation. I find, however, that several of the inconsistencies between the current study and previous studies from other laboratories, including...

Reduced GLP-1 Secretion at 30 Minutes After a 75-g Oral Glucose Load Is Observed in Gestational Diabetes Mellitus: A Prospective Cohort Study

Glucagon-like peptide 1 (GLP-1) levels may be reduced in type 2 diabetes, but whether a similar impairment exists in gestational diabetes mellitus (GDM) has not been established. We studied this in a prospective cohort study of pregnant women ( n = 144) during oral glucose tolerance test (OGTT). GLP-1, glucose, and insulin were sampled at 30-min intervals during a 2-h 75-g OGTT...

Expression of Concern. Kathrin Maedler, Desiree M. Schumann, Fabienne Schulthess, José Oberholzer, Domenico Bosco, Thierry Berney, and Marc Y. Donath. Aging Correlates With Decreased β-Cell Proliferative Capacity and Enhanced Sensitivity to Apoptosis: A Potential Role for Fas and Pancreatic Duodenal Homeobox-1. Diabetes 2006;55:2455–2462. DOI: 10.2337/db05-1586. PMID: 16936193

On the basis of the recommendation of the American Diabetes Association’s Panel on Ethical Scientific Programs (ESP), the American Diabetes Association, the publisher of Diabetes, is issuing this expression of concern to alert readers to questions about the reliability of the data in the above-cited article. The American Diabetes Association was recently notified about an...

Mitochondrial ADP Sensitivity and Transport: New Insights Into Diet-Induced Mitochondrial Impairments

In the quest to understand the etiology and pathophysiology of insulin resistance and type 2 diabetes (T2DM), a body of evidence representing nearly two decades of research points a finger at mitochondria as organelles of great interest (1–3). The term “mitochondrial dysfunction” was born following early reports that these organelles exhibited altered abundance and morphology (1...

The Ascending GLP-1 Road From Clinical Safety to Reduction of Cardiovascular Complications

Glucagon-like peptide 1 (GLP-1) was originally identified as a gut-derived incretin hormone that lowered glycemia through potentiation of glucose-dependent insulin secretion. Subsequent studies expanded the actions of GLP-1 to include inhibition of glucagon secretion, gastric emptying, and appetite, collectively useful attributes for a glucose-lowering agent. The introduction of...