BioMedical Engineering OnLine

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List of Papers (Total 1,284)

Optimal combination of electrodes and conductive gels for brain electrical impedance tomography

Electrical impedance tomography (EIT) is an emerging imaging technology that has been used to monitor brain injury and detect acute stroke. The time and frequency properties of electrode–skin contact impedance are important for brain EIT because brain EIT measurement is performed over a long period when used to monitor brain injury, and is carried out across a wide range of...

A refined method of quantifying deceleration capacity index for heart rate variability analysis

Phase-rectified signal averaging (PRSA) was often applied to assess the cardiac vagal modulation. Despite its broad use, this method suffers from the confounding effects of anomalous variants of sinus rhythm. This study aimed to improve the original PRSA method in deceleration capacity (DC) quantification. The refined deceleration capacity (DCref) was calculated by excluding from...

A knowledge discovery methodology from EEG data for cyclic alternating pattern detection

Detection and quantification of cyclic alternating patterns (CAP) components has the potential to serve as a disease bio-marker. Few methods exist to discriminate all the different CAP components, they do not present appropriate sensitivities, and often they are evaluated based on accuracy (AC) that is not an appropriate measure for imbalanced datasets. We describe a knowledge...

Uniqueness of local myocardial strain patterns with respect to activation time and contractility of the failing heart: a computational study

Myocardial deformation measured by strain is used to detect electro-mechanical abnormalities in cardiac tissue. Estimation of myocardial properties from regional strain patterns when multiple pathologies are present is therefore a promising application of computer modelling. However, if different tissue properties lead to indistinguishable strain patterns (‘degeneracy’), the...

Adaptive filtering of physiological noises in fNIRS data

The study presents a recursive least-squares estimation method with an exponential forgetting factor for noise removal in functional near-infrared spectroscopy data and extraction of hemodynamic responses (HRs) from the measured data. The HR is modeled as a linear regression form in which the expected HR, the first and second derivatives of the expected HR, a short-separation...

Imbalanced biomedical data classification using self-adaptive multilayer ELM combined with dynamic GAN

Imbalanced data classification is an inevitable problem in medical intelligent diagnosis. Most of real-world biomedical datasets are usually along with limited samples and high-dimensional feature. This seriously affects the classification performance of the model and causes erroneous guidance for the diagnosis of diseases. Exploring an effective classification method for...

Evaluation of texture features at staging liver fibrosis based on phase contrast X-ray imaging

The purpose of this study is to explore the potential of phase contrast imaging to detect fibrotic progress in its early stage; to investigate the feasibility of texture features for quantified diagnosis of liver fibrosis; and to evaluate the performance of back propagation (BP) neural net classifier for characterization and classification of liver fibrosis. Fibrous mouse liver...

Computational analysis of the hemodynamic characteristics under interaction influence of β-blocker and LVAD

Hemodynamic characteristics of the interaction influence among support level and model of LVAD, and coupling β-blocker has not been reported. In this study, the effect of support level and model of LVAD on cardiovascular hemodynamic characteristics is investigated. In addition, the effect of β-blocker on unloading with LVAD is analyzed to elucidate the mechanism of LVAD coupling...

Effect of hip joint angle at seat-off on hip joint contact force during sit-to-stand movement: a computer simulation study

Sit-to-stand movements are a necessary part of daily life, and excessive mechanical stress on the articular cartilage has been reported to encourage the progression of osteoarthritis. Although a change in hip joint angle at seat-off may affect hip joint contact force during a sit-to-stand movement, the effect is unclear. This study aimed to examine the effect of the hip joint...

Semivariogram and Semimadogram functions as descriptors for AMD diagnosis on SD-OCT topographic maps using Support Vector Machine

Age-related macular degeneration (AMD) is a degenerative ocular disease that develops by the formation of drusen in the macula region leading to blindness. This condition can be detected automatically by automated image processing techniques applied in spectral domain optical coherence tomography (SD-OCT) volumes. The most common approach is the individualized analysis of each...

Effects on the pulmonary hemodynamics and gas exchange with a speed modulated right ventricular assist rotary blood pump: a numerical study

Rotary blood pumps (RBPs) are the newest generation of ventricular assist devices. Although their continuous flow characteristics have been accepted widely, more and more research has focused on the pulsatile modulation of RBPs in an attempt to provide better perfusion. In this study, we investigated the effects of an axial RBP serving as the right ventricular assist device on...

Fine-grain recordings of the electrically evoked compound action potential amplitude growth function in cochlear implant recipients

In cochlear implants (CI) measuring the electrically evoked compound action potential (ECAP) has become an important tool for verifying the electrode-nerve interface as well as establishing a basis for a map to program the speech processor. In a standard clinical setup recordings are averaged over 25–100 repetitions to allow for the detection of ECAPs within the noise floor. To...

Evaluation of spatial distribution and characterization of wall shear stress in carotid sinus based on two-dimensional color Doppler imaging

This study aims to use a wall shear stress (WSS) quantitative analysis software to analyze and evaluate the carotid sinus WSS spatial distribution and characteristics in intima-media thickness (IMT) normal and thickening group by using two-dimensional color doppler flow imaging (CDFI) so as to assist clinicians to predict the location and risk of plaque formation. According to...

An efficient optic cup segmentation method decreasing the influences of blood vessels

Optic cup is an important structure in ophthalmologic diagnosis such as glaucoma. Automatic optic cup segmentation is also a key issue in computer aided diagnosis based on digital fundus image. However, current methods didn’t effectively solve the problem of edge blurring caused by blood vessels around the optic cup. In this study, an improved Bertalmio–Sapiro–Caselles–Ballester...

Ambulatory blood pressure monitoring in children suffering from orthostatic hypertension

It is particularly important to utilize appropriate blood pressure measurement methods to evaluate the changes of orthostatic hypertension (OHT) for children, and this study was designed to analyze the blood pressure type in OHT children with 24 h semiautomatic ambulatory blood pressure monitoring. Children who were diagnosed by head-up tilt table test as OHT patients (OHT group...

Changes in heart rate variability with respect to exercise intensity and time during treadmill running

Heart rate variability (HRV) arises from the complex interplay of sympathetic and parasympathetic autonomic regulation of heart rate. Ultra-low frequency (ULF) and very-low frequency (VLF) components of HRV play a crucial role in automatic HR controllers, but these frequency bands have hitherto largely been neglected in HRV studies. The aim of this work was to investigate changes...

Dynamic stability and spatiotemporal parameters during turning in healthy young adults

Turning while walking has a frequent occurrence in daily life. Evaluation of its dynamic stability will facilitate fall prevention and rehabilitation scheme. This knowledge is so limited that we set it as the first aim of this study. Another aim was to investigate spatiotemporal parameters during turning. Fifteen healthy young adults were instructed to perform straight walking...

A super-resolution method-based pipeline for fundus fluorescein angiography imaging

Fundus fluorescein angiography (FFA) imaging is a standard diagnostic tool for many retinal diseases such as age-related macular degeneration and diabetic retinopathy. High-resolution FFA images facilitate the detection of small lesions such as microaneurysms, and other landmark changes, in the early stages; this can help an ophthalmologist improve a patient’s cure rate. However...

Comparative mechanical analysis of deep brain stimulation electrodes

The new field of neuro-prosthetics focuses on the design and implementation of neural prostheses to restore some of the lost neural functions. The electrode-tissue contacts remain one of the major obstacles of neural prostheses microstructure. Recently, Microelectrode fabrication techniques have been developed to have a long-term and stable interface with the brain. In this paper...

The effect of virtual reality-based balance training on motor learning and postural control in healthy adults: a randomized preliminary study

Adults with sedentary lifestyles seem to face a higher risk of falling in their later years. Several causes, such as impairment of strength, coordination, and cognitive function, influence worsening health conditions, including balancing ability. Many modalities can be applied to improve the balance function and prevent falling. Several studies have also recorded the effects of...

DigitalMe: a journey towards personalized health and thriving

The use of information and communication technologies for health (eHealth) delivered via mobile-based or digitally enhanced solutions (mHealth) have rapidly evolved. When used together across various mobile applications and devices eHealth and mHealth technologies have the ability to passively monitor behavior as an indicator of socialization and mood; accumulate a range of...