Comparative Clinical Pathology

https://link.springer.com/journal/580

List of Papers (Total 76)

Anaplasma ovis infection in goat flocks around Gaborone, Botswana

Anaplasma is a genus of gram-negative, intracellular bacteria infecting different blood cells in animals. A. ovis infects erythrocytes of sheep and goats, inducing clinical signs that include haemolytic anaemia, icterus and loss of production. Aim of this study was to evaluate the prevalence of Anaplasma spp. in goats in smallholder flocks around Gaborone, Botswana. Whole blood...

Hematology, plasma biochemistry, and hormonal analysis of captive Louisiana pine snakes (Pituophis ruthveni): effects of intrinsic factors and analytical methodology

Blood analyte data are useful in health assessments and management of reptiles. There is a knowledge gap for blood analyte data of the endangered Louisiana pine snake (LPS; Pituophis ruthveni). The objectives of this study were to provide baseline hematology, plasma biochemical, and hormone data of captive LPS, to compare the data in juvenile and adult snakes and in adult snakes...

Respiratory and GIT tract immune responses of broiler chickens following experimental infection with Newcastle disease’s virus

Newcastle disease causes a lymphoproliferative response in the tracheal and intestinal mucosa of the infected birds. In this study, the Hitchner B1 and I-2 vaccine and challenging of ND field strains were used to evaluate the populations of T lymphocyte subsets infiltrated intestinal and tracheal, also to shed some light on cell-mediated immune response using enzyme-linked...

Effects of strain, sex and age on immunophenotyping parameters in the rat and mouse

Immunophenotyping of lymphocyte subsets can be a useful addition to toxicological or investigatory studies where there is the potential for effects on the immune system. We have validated assays for rat or mouse lymphocytes using a FACSVerse flow cytometer and FACSuite software, with commercially available antibodies. Whole blood was stained using the following markers: Rat—CD3...

BIO (6-bromoindirubin-3′-oxime) GSK3 inhibitor induces dopaminergic differentiation of human immortalized RenVm cells

Parkinson’s disease (PD) is one of the most neurodegenerative disorders which can lead to severe neural disability and neurological defects. Cell-based therapy using fully differentiated cells is a new method for the treatment of this abnormal condition. In the present study, we investigated the effects of 6-bromoindirubin-3′-oxime (BIO) on dopaminergic differentiation of human...

CD58; leucocyte function adhesion-3 (LFA-3) could be used as a differentiating marker between immune and non-immune thyroid disorders

The link between Graves’ disease (GD) and Hashimoto’s thyroiditis (HT) has been debated for decades due to the shared pathological and immunological components. Immune intolerance and inappropriate immune reaction against self-thyroid cells are distinctive features of both diseases, but definitive data for the clinical presentation of autoimmune thyroid disease remains unclear...

Histological exhibition of the gastroprotective effect of Moringa oleifera leaf extract

The gastroprotective activity of Moringa oleifera leaf extract against aspirin-induced ulcers was investigated in rats. Thirty (30) rats under starvation but with access to drinking water for 48 h were divided into 6 groups of 5 animals each. Animals in groups 1 and 2 were pretreated with 0.2 ml normal saline via the oral route. Group 3 received 32 mg/kg cimetidine while those in...

Correction to: Effects of dust particles on body weight and some haematological parameters in rats in Maiduguri metropolis, Nigeria

The original version of this paper unfortunately captured the name of Dr. Yahi incorrectly. It should be Dauda Yahi instead of Y. Dauda in the original paper.

Effects of repeated restraint and blood sampling with needle injection on blood cardiac troponins in rats, dogs, and cynomolgus monkeys

While cardiac troponins (cTnT and cTnI) have been used as blood biomarkers of myocardial injury such as myocardial infarction in both humans and animals, their high diagnostic sensitivity inevitably leads to decreased diagnostic specificity. For example, it is difficult to judge whether a slight increase of cardiac troponins in toxicological studies is a treatment-related...

Prevalence of Sarcocystis infection in processed meat products by using digestion and impression smear methods in Hamedan, Iran

Sarcocystis is a common zoonotic parasite which can be transmitted through ingestion of contaminated, undercooked meat and is a major cause of economic loss in many countries. This study aimed to detect Sarcocystis parasite in processed meat products in Hamedan, Iran. A total of 20 samples of hamburger, sausage, and cocktail were collected from markets from three factories in...

An association study between CHEK2 gene mutations and susceptibility to breast cancer

CHEK2 gene is known as a tumor suppressor gene in breast cancer (BC), which plays a role in DNA repair. The germ line mutations in CEHK2 have been associated with different types of cancer. The present study was aimed at studying the association between CHEK2 mutations and BC. Peripheral blood was collected from patients into a test tube containing EDTA, and DNA was extracted...

Diffuse type testicular seminoma in a stallion

A 7-year-old stallion with progressive left testicular enlargement was presented. Grossly, the excised testicle measured 25 × 15 × 12 cm and weighed 3.7 kg. It was multinodular with a gray-white surface; however, the right testis was normal. Histologically, the neoplastic cells were disseminated diffusely in the tumoral stroma with a minimal fibrovascular stroma. Neoplastic cells...