The Journal of Headache and Pain

https://thejournalofheadacheandpain.biomedcentral.com

List of Papers (Total 2,451)

A population-based follow-up study of headache from age 7 to 22 years

To study changes in headache prevalence during childhood, adolescence and early adulthood, we performed a prospective long-term follow-up study on an unselected child population. Seven-year-old children, resident in a Finnish city and starting primary school, were followed for 15 years. Data were collected at the ages of 7, 13, 14, and 22 years. Number of children participating...

Pain reactivity in children with autistic disorder

Abnormal pain reactivity is often reported by the parents of children with autistic disorder (AD). This is an interesting feature because it could be related to some neurochemical findings frequently reported in autism. The aim of the present study is to report the preliminary findings about pain reactivity in children with autism, and to relate them to serotoninemia. We studied...

The importance of anxiety and depression as factors in chronicization of primary headaches

A multicenter study was carried out in 10 Italian headache centers to investigate the prevalence of anxiety and depression in patients with chronic daily headache(CDH). The study investigated 219 patients (171 F; 48 M) including 53 cases of chronic tension-type headache (CTTH), 99 cases of CTTH+ migraine and 67 cases of transformed migraine (TM). The type of headache diagnosed at...

Primary headache and comorbidity with mood and anxiety disorders: an example of the psycho-neuro-biological loop

Although an association between primary headache and psychiatric disorders, has been recognised for over 100 years, this association has been investigated systematically only recently. The nature of this association has also been examined in recent studies. Real comorbidity implies that primary headache and psychiatric disorders are indipendent phenomena, i.e. a casual co...

CACNA1A gene mutations in familial hemiplegic migraine

Familial hemiplegic migraine (FHM) is an autosomal dominant subtpye of migraine with aura. A few years ago, the gene linked to FHM was identified. CACNA1A encodes a voltage-activated, pore-forming α1A subunit of the P/Q-type calcium channel. At present, an increasing number of mutations have been identified in this gene in patients with FHM. Genotype-phenotype comparisons have...

The blink reflex in chronic cluster headache: a comparison with migraine patients suffering from unilateral pain

Objective. To evaluate the blink reflex (BR) in chronic cluster headache (CH) patients. Design. The elecrophysiological data were collected in during the headache-free phase. Setting. Headache patients were recruited from outpatients seen for the first time at the First Neurologic Clinic of Bari University. Patients and participants. Ten CH patients, 19 migraine without aura...

Role of dopaminergic system in migraine

The theory that hypersensitivity of dopamine (DA) system is involved in the pathogenesis of migraine has been supported by various authors on the basis of clinical, pharmacological and, recently, genetic evidence. Apomorphine, a selective and specific DA agonist, has a cerebral vasodilatatory effect and increases blood flow significantly in the middle cerebral artery in...

Visual stress–induced migraine aura compared to spontaneous aura studied by magnetoencephalography

DC MEG shifts, similar and complex in waveform, were observed in visually induced migraine with aura patients similar to spontaneous aura but not controls. Multiple cortical areas were activated in visually induced and spontaneous aura patients. In normal subjects activation was only observed in the primary visual cortex. Results support a spreading depression–like neuroelectric...

A double-blind crossover comparison of the effects of vigabatrin with placebo in the prevention of migraine headache

Twenty-three patients, aged 18‐66 years and suffering from migraine with or without aura, were randomly selected to receive either vigabatrin or matched placebo tablets first for 12 weeks in a double-blind crossover study. Alternative treatment was given after a 4-week washout period. The dose of medication was titrated to a maximum of 4 tablets (2 g vigabatrin) daily according...

Evaluating the economic costs of migraine: interest of a comparative approach

The major aim of the paper is to give an epidemiologist's viewpoint on several points related to the evaluation of the costs of migraine and to answer some questions that are important if one wishes to decrease the burden of this disease in the general population. In spite of favourable criteria for the management of migraine, and for epidemiologic and economic studies, the...

Analgesic therapy for headache: consumption, appropriateness and costs

Headache represents not only an individual disease, but also an important pathology for society because its prevalence in the population is about 50.0%. Its physical, emotional, social and economic impacts are often neglected and it is only recently that headache is being considered in a public health perspective, especially its disabling burden, its treatment and its costs. The...

Patients’ postures during migraine attacks

The aim of this study was to determine postures adopted by patients during migraine attack. A total of 199 migraine patients were questioned about their postures during the migraine attack. Of these, 92 patients did not choose a specific lying position, 22 could not lie down during the attack because of the increase in pain, while 6 avoided lying due to scalp tenderness. During...

Botulinum toxin type A in prophylactic treatment of migraine headaches: a preliminary study

The purpose of this study was to determine the safety and efficacy of botulinum toxin type A (BOTOX; Allergan, Irvine, USA) in migraine prophylaxis. We performed a double-blind, randomized, 90-day placebo-controlled study that enrolled 30 adult migraineurs. Patients received 50 units botulinum toxin type A (n=15) or placebo (n=15). Outcome measures were monthly frequency and...

Cervical muscles in the pathogenesis of migraine headache

The pathogenesis of migraine headache is poorly understood but the trigeminovascular system seems to play an important role in it. The trigeminal nucleus caudalis is sensitised by noxious sensory stimuli, often from convergent afferents originating from a variety of tissues. In this paper, we review evidence to support the view that the cervical muscles play a role in the...

Does repeated subcutaneous administration of sumatriptan produce an unfavorable evolution in cluster headache?

Cluster headache (CH) is one of the most painful primitive headaches that exists. Since 1991, the subcutaneous administration of sumatriptan (SCS) in the treatment of acute attacks has proved to be rapid and effective. Moreover, SCS has an excellent safety-efficacy ratio. To date, there is no information on the modalities of SCS use by CH patients, and on its possible overuse. In...

Functional imaging of subcortical nociceptive structures in response to treatment of chronic daily headache

The objective was to provide objective imaging evidence of functional changes in brainstem structures involved in chronic daily headache (CDH). Over time, episodic migraine (EM) patients may develop CDH known as transformed migraine (TM). Using analysis of transverse relaxation rates, R2, R2* and R2’ (R2* values are reflective of blood oxygen level dependence; R2’ is a measure of...

Hemicrania continua

Hemicrania continua was described in 1984 by Sjastaad and Spierings as a unilateral, almost always side-locked headache that is continuous and fluctuating in intensity. There are added pain exacerbation periods of varying frequency, consisting of more severe headache, of at least moderate intensity, lasting from hours to days. The condition is either absolutely responsive to...

Optimising migraine treatment: from drug-drug interactions to personalized medicine

Migraine is the most disabling and expensive chronic disorders, the etiology of which is still not fully known. The neuronal systems, (glutammatergic, dopaminergic, serotoninergic and GABA-ergic) whose functionality is partly attributable to genetically determined factors, has been suggested to play an important role. The treatment of acute attacks and the prophylactic management...

Physician and patient preferences for dosing options in migraine prevention

Adherence to a therapy, though a key factor for successful treatment, is low among patients with chronic conditions such as migraine. Dose frequency plays a major role in adherence. This study evaluated the impact of having flexible dosing options on acceptance of and adherence to a new migraine preventive therapy class among adults with migraine. In this observational study, two...

Understanding the nature of psychiatric comorbidity in migraine: a systematic review focused on interactions and treatment implications

BackgroundMigraine is a highly prevalent and disabling neurological disorder which is commonly linked with a broad range of psychiatric comorbidities, especially among subjects with migraine with aura or chronic migraine. Defining the exact nature of the association between migraine and psychiatric disorders and bringing out the pathophysiological mechanisms underlying the...

Physician and patient preferences for dosing options in migraine prevention

BackgroundAdherence to a therapy, though a key factor for successful treatment, is low among patients with chronic conditions such as migraine. Dose frequency plays a major role in adherence. This study evaluated the impact of having flexible dosing options on acceptance of and adherence to a new migraine preventive therapy class among adults with migraine.MethodsIn this...

Advanced visual network and cerebellar hyperresponsiveness to trigeminal nociception in migraine with aura

BackgroundDespite the growing body of advanced studies investigating the neuronal correlates of pain processing in patients with migraine without aura (MwoA), only few similar studies have been conducted in patients with migraine with aura (MwA). Therefore, we aimed to explore the functional brain response to trigeminal noxious heat stimulation in patients with MwA...

Effects of monoclonal antagonist antibodies on calcitonin gene-related peptide receptor function and trafficking

BackgroundMonoclonal antibodies against calcitonin gene-related peptide (CGRP) or its receptor are efficacious for the prevention of migraine headaches. The downstream molecular mechanisms following ligand-receptor blockade by which these antibodies prevent CGRP signaling through CGRP receptors have not been demonstrated.MethodsHere we produced tool monoclonal functional...