Journal of Chemistry

https://www.hindawi.com/journals/jchem/

List of Papers (Total 5,504)

Screening of Nutritional Parameters for the Production of Protease from Aspergillus Oryzae

Production of protease enzyme by fungus Aspergillus oryzae was investigated. The proteolytic activity was observed when the fungus was grown in the medium containing glucose, malt extract, yeast extract, peptone, K2HPO4, MgSO4 and FeSO4. The present paper describes the screening of media components and fermentation conditions in shake flask. The organism utilized carbon sources...

Thermal Properties of Some Organic Liquids Using Ultrasonic Velocity Measurements

Debye temperature and thermal relaxation time has been calculated in normal and boiling temperature. Using thermal relaxation time, the heat of fusion has been calculated for nineteen organic liquids and the results throw light on the method of calculating heat of fusion.

Microwave-Assisted, One-Pot Three Component Synthesis of 2-Phenyl H-imidazo[1,2-α]pyridine

A novel synthesis of 2-phenylH-imidazio[1,2-α] pyridines is described from a one-pot, three-component reaction between pyridine, guanidine (urea or thiourea) and α-bromoketones under microwave irradiation and solvent-free conditions in excellent yields.

Photocatalytic Degradation of Thiram (Fungicides) under Visible Light Irradiation

Pesticides in the different form are toxic to the environment and removal of its form the various sources is a difficult task. The thiram undergoes photocatalytic degradation under visible light when prepared TiO2∼PVA polymer composite was used as a photocatalyst. The data represent that prepared TiO2∼PVA polymer composite is a more efficient photocatalyst than the neat TiO2...

Synthesis and Antimicrobial Activity of Some Chalcone Derivatives

In an effort to develop antimicrobial agents, a series of chalcones were prepared by Claisen-Schmidt condensation of appropriate acetophenones with appropriate aromatic aldehydes in the presence of aqueous solution of potassium hydroxide and ethanol at room temperature. The synthesized compounds were characterized by means of their IR, 1H-NMR spectral data and elemental analysis...

Synthesis of Multi-substituted 4,5-Dihydrofuran Derivatives from (S)-Limonene and 1,3-Dicarbonyl Compounds and their Biological Activities

Multi-substituted 4,5-dihydrofuran derivatives were regioselectively synthesized by the reaction of α-carbo radical produced from 1,3-dicarbonyl compounds by oxidation with Mn(OAc)3 in Acetic acid and S-(-)-limonene. All the compounds were tested for their antibacterial and antifungal activities by the disc-diffusion technique.

Physicochemical and Heavy Metals Assessments of Leachates from Aperin Abandoned Dumpsite in Ibadan City, Nigeria

Leachates from Aperin dumpsite and control site in Ibadan city, were analysed for physicochemical properties and heavy metals levels. These parameters were compared with control samples and established international standards (FEPA) and (WHO). The dumpsite leachates contained very high concentration of TDS (2436±1035 mg/L) and significant concentrations of COD (395±135 mg/L), BOD...

A New Ritodrine Selective Electrode and its Pharmaceutical Application

A novel ritodrine hydrochloride ion-selective PVC membrane electrode based on ion-pair complex of ritodrine-tetra phenyl borate was prepared with di-n-butyl phosphate as a plasticizer. The influences of membrane composition, temperature, pH of the test solution and foreign ions on the electrode performance were investigated. The electrode showed a Nernstian response over a wide...

Synthesis, Spectral and Magnetic Studies of Newly Mixed-Ligand Complexes of 4-Formyl-Acetanilide Thiosemicarbazone and 3,4-Dihydrocinnamic Acid with Some Metal Ions

New complexes with thiosemicarbazone derivative and 3, 4-dihydrocinnamic acid were prepared and characterized by elemental analysis, determination of metal, IR, 1H NMR, electronic spectroscopy and magnetic measurements. The thiosemicarbazone derivative forms bidentate ligand complexes of the general formula, [M(Thz)(Caf)] where Thz = 4-formyl- acetanilide thiosemicarbazone, Caf...

Synthesis and In Vitro Cytotoxic Activity of 2-Amino-7-(dimethylamino)-4-[(trifluoromethyl)phenyl]-4H-chromenes

Three 2-amino-4-(trifluoromethylphenyl)-3-cyano-7-(dimethylamino) -4H-chromene derivatives were synthesized and their cytotoxic activities were determined against six human tumor cell lines using MTT assay. Condensation of 3-(dimethylamino)phenol, trifluoromethybenzaldehydes and malonitrile in ethanol containing piperidine afforded corresponding chromenes (4a-c). The structure of...

Synthesis and Antimicrobial Activity ofSome New Thioether Derivatives of Quinoxaline

2-Chloro-3-methylquinoxaline was selected as nucleus around which the molecular manipulations were carried out to get new compounds expected to possess better anti microbial activity. Various quinoxaline derivatives have been synthesized by replacing the chlorine at C-2 with a thioether linkage, which in turn attached to 2-(N-(substituted phenyl)acetamides. The synthesized...

Combination of First Derivative Spectrophotometry and H-Point Standard Addition Method for Simultaneous Determination of Guaifenesin and Theophylline in Cough Syrup

Combination of first derivative spectrophotometric and H-point standard addition method (HPSAM) has been applied for simultaneous determination of guaifenesin and theophylline. First derivative signals at the two pairs of wavelengths, 282.0-290.2 nm and 277.4-287.8 nm were monitored with the addition of standard solutions of both guaifenesin and theophylline in the ratio of 1:1...

Adsorption of U(VI) from Aqueous Solution onto Hydrotalcite-Like Compounds

Uranium adsorption by the synthesized compound of magnesium aluminum hydroxide hydrate – layered double hydrotalcite (STH)-like compounds was studied. The calcinated STH was proven to be a highly effective in U(VI) adsorption in pH range from 6.5 to 7. The time dependent experimental data were found to be fit to the pseudo-second-oder model. The equilibrium data have been modeled...

Evaluation of Trihalomethane Formation Potential Due To Anthropogenic Sources in the Ground Water of Kanpur

The ground water of Jajmau(which is the hub of tanneries), Kanpur has been evaluated for trihalomethane formation potential in January and May, 2009.Bromide is absent. Chloroform is the only THM species identified in all the ground water samples. The levels of chloroform are found below the regulated WHO guideline value of 300 μgL-1.THM formation rate is very fast in first 24 h...

Microwave-Assisted, One-Pot Three Component Synthesis of 2-Phenyl H-imidazo[1,2-α]pyridine

A novel synthesis of 2-phenylH-imidazio[1,2-α] pyridines is described from a one-pot, three-component reaction between pyridine, guanidine (urea or thiourea) and α-bromoketones under microwave irradiation and solvent-free conditions in excellent yields.

Synthesis of Schiff Bases of 2-amino-5-aryl-1,3,4-thiadiazole and Its Analgesic, Anti-Inflammatory and Anti-Bacterial Activity

Schiff Bases of 2-amino-5-aryl-1,3,4-thiadiazole derivatives have been synthesized with different aromatic aldehyde. 1,3,4-thiadiazole derivatives were prepared by the reaction of thiosemicarbazide, sodium acetate and aromatic aldehyde. The structures of the titled Schiff bases were elucidated by IR and 1H NMR spectral measurements. All the compounds were evaluated for their...

A New Alternative Synthesis of Salicylaldazine via Microwave Irradiation Method

Two diazine Schiff base ligands, HLa and HLb, derived from thiocarbohydrazide and salicylaldehyde derivatives were synthesized using the microwave-assisted synthesis approach. The confirmation of both ligands was elucidated through physiochemical and spectroscopy techniques as well as single X-ray crystallography diffraction. The analyses showed that the ligands synthesized were...

Synthesis and Antimicrobial Activity of 1,2,4-Triazoles

Several 3-(4'-nitrophenyl)-4-(4"-chloro benzamido)-5-substituted phenyl)-4H-1,2,4-triazole (3a-3e) and 3-(4'-nitrophenyl)-4-(4"-methyl benzenesulphonamido)-5-substituted phenyl)-4H-1,2,4-triazole (4a-4e) have been synthesised. Representative compounds were screened for antibacterial, antifungal activity. Most of them showed significant antibacterial activity.

A Study of Substituted Aliphatic Sulphides on the Corrosion Behaviour of Zinc in Ammonium Chloride Solution

Sulphur containing organic compounds decreases the corrosion rate by increasing the hydrogen over potential on zinc metal due to their electron donating groups. Their inhibiting effect was found to be associated with their adsorption on the active centers of the metal. The inhibition efficiencies of some aliphatic sulphides in ammonium chloride solution have been studied by...

Synthesis and Characterization of D-Lyxono-γ-lactone

D-lyxono-γ-lactone has been prepared in two steps from galactose. The first step potassium lyxonate was obtained in 64% yield and the title compound has been isolated in next step with 75% yield. The structures of the products were characterized by IR, 1H, 13C, mass and microanalysis study.

Development of RP-HPLC Method for the Estimation of Rabeprazole in Pure and Tablet Dosage Form

A simple, rapid, sensitive and precise High Performance Liquid Chromatographic (HPLC) method has been developed for the estimation of rabeprazole in bulk and tablet dosage form. In this method RP-C18 column (150 mm x 4.6 mm I.D, 5 µ m particle size) with mobile phase consisting of methanol and water in the ratio of 65:35 v/v in isocratic mode was used. The detection wavelength is...

Mining the Information for Structure Based Drug Designing by Relational Database Management Notion

Structure based drug design is a technique that is used in the initial stages of a drug discovery program. The role of various computational methods in the characterization of the chemical properties and behavior of molecular systems is discussed. The field of bioinformatics has become a major part of the drug discovery pipeline playing a key role for validating drug targets. By...

Rapid, Sensitive and Validated Ultra-Performance Liquid Chromatography/Mass Spectrometric Method for the Determination of Fenofibric Acid and its Application to Human Pharmacokinetic Study

The first, rapid and sensitive ultra performance liquid chromatography mass spectrometric method for the determination of fenofibric acid, the active metabolite of fenofibrate, a lipid regulating agent, in human EDTA plasma has been developed and validated using fenofibric d6 acid as internal standard and Waters LC-MS/MS. Negative ions of fenofibric acid and fenofibric d6 acid...

Isolation, Characterization and Antibacterial Activity Screening of Anthocyanidine Glycosides from Alchornea Cordifolia (Schumach. and Thonn.) Mull. Arg. Leaves

From the ethanolic extract of the leaves of Alchornea cordifolia (Schumach. and Thonn.) Mull. Arg,, 5–methyl 4’ -propenoxy anthocyanidines 7-O-β-D – diglucopyranoside was isolated. The structure was elucidated using NMR spectroscopy in combination with IR and MS spectral data. Antibacterial studies showed that the isolated compound successfully inhibited Pseudomonas aerguinosa...

Simple UV Spectrophotometric Determination of Duloxetine Hydrochloride in Bulk and in Pharmaceutical Formulations

A new, simple and sensitive spectrophotometric method in ultraviolet region has been developed for the determination of duloxetine hydrochloride in bulk and in pharmaceutical formulations. Duloxetine hydrochloride exhibits absorption maxima at 288 nm with apparent molar absorptivity of 0.97x104 L/mol.cm in 0.1 N HCL. Beer's law was found to be obeyed in the concentration range of...