Journal of Chemistry

https://www.hindawi.com/journals/jchem/

List of Papers (Total 6,308)

A Novel Method for the Synthesis of Dipyrromethanes Under Solvent-Free Condition

This study describes a successful approach for the synthesis of dipyrromethanes using iodine as a catalyst on grinding. This protocol does not require any solvent and carried out at lowest pyrrole/aldehyde ratio which makes this method economically and environmentally attractive. This protocol affords the products immediately with excellent yield.

Solvent-Free Synthesis of 1,8-Dioxo-octahydroxanthenes and 14-Aryl-14H-dibenzo[a,j]xanthenes using Saccharin Sulfonic Acid as an Efficient and Green Catalyst

Saccharin sulfonic acid (SaSA) is utilized as a highly efficient, green and inexpensive sulfonic acid-containing catalyst for the following one-pot multi-component organic transformations: (i) the condensation of dimedone (2 eq.) with aromatic aldehydes (1 eq.) leading to 1,8-dioxo-octahydroxanthenes, and (ii) the reaction of 2-naphthol (2 eq.) with arylaldehydes (1 eq.) leading...

Syntheses, Characterization, and Antimicrobial Screening of N-(benzothiazol-2-yl)benzenesulphonamide and its Cu(I), Ni(II), Mn(II), Co(II), and Zn(II) Complexes

N-(benzothiazol-2-yl)benzenesulphonamide (BS2ABT) was synthesized by the condensation (by refluxing) of 2-aminobenzothiazole and benzenesulphonylchloride in acetone at 140ºC. The resulting crude precipitates were recrystallized from dimethylformamide (DMF). Five metal complexes of copper(I), nickel(II), manganese(II), cobalt(II) and zinc(II) of the ligands were synthesized. The...

Synthesis, Evaluation and Characterization of Some 1,3,4-Triazole-2-one Derivatives as Antimicrobial Agents

A series of novel compounds like 3[(phenyl substituted)-5-methyl-1(Benzosulphonylamine)]-1,3,4-triazole-2-ones II(a-f) were synthesized by treating 4-amino-1-phenyl-3-methyl-5-oxo-1,2,4-triazoles with benzene sulphonyl chloride using pyridine as solvent. Similarly by using 4-amino-1-aryl-3-methyl-5-oxo-1,2,4-triazoles and acetic anhydride as starting material 3[(phenyl...

Synthesis of Schiff Bases of 2-amino-5-aryl-1,3,4-thiadiazole and Its Analgesic, Anti-Inflammatory and Anti-Bacterial Activity

Schiff Bases of 2-amino-5-aryl-1,3,4-thiadiazole derivatives have been synthesized with different aromatic aldehyde. 1,3,4-thiadiazole derivatives were prepared by the reaction of thiosemicarbazide, sodium acetate and aromatic aldehyde. The structures of the titled Schiff bases were elucidated by IR and 1H NMR spectral measurements. All the compounds were evaluated for their...

Functionalized Carbon Nanotubes with Gold Nanoparticles to Fabricate a Sensor for Hydrogen Peroxide Determination

A highly sensitive electrode was prepared based on gold nanoparticles/nanotubes/ionic liquid for measurement of Hydrogen peroxide. Gold nanoparticles of 20–25 nm were synthesized on a nanotube carbon paste electrode by cyclic voltammetry technique while the coverage was controlled by applied potential and time. The gold nanoparticles were modified to form a monolayer on CNT...

A New Alternative Synthesis of Salicylaldazine via Microwave Irradiation Method

Two diazine Schiff base ligands, HLa and HLb, derived from thiocarbohydrazide and salicylaldehyde derivatives were synthesized using the microwave-assisted synthesis approach. The confirmation of both ligands was elucidated through physiochemical and spectroscopy techniques as well as single X-ray crystallography diffraction. The analyses showed that the ligands synthesized were...

The Gas-Phase Heats of Formation of n-Alkanes as a Function of the Electrostatic Potential Extrema on their Molecular Surfaces

The hybrid density functional B3LYP is employed to map the molecular electrostatic potentials on the surfaces of twenty normal alkanes, (Cn H2n

Synthesis and Antimicrobial Activity of 1,2,4-Triazoles

Several 3-(4'-nitrophenyl)-4-(4"-chloro benzamido)-5-substituted phenyl)-4H-1,2,4-triazole (3a-3e) and 3-(4'-nitrophenyl)-4-(4"-methyl benzenesulphonamido)-5-substituted phenyl)-4H-1,2,4-triazole (4a-4e) have been synthesised. Representative compounds were screened for antibacterial, antifungal activity. Most of them showed significant antibacterial activity.

A Study of Substituted Aliphatic Sulphides on the Corrosion Behaviour of Zinc in Ammonium Chloride Solution

Sulphur containing organic compounds decreases the corrosion rate by increasing the hydrogen over potential on zinc metal due to their electron donating groups. Their inhibiting effect was found to be associated with their adsorption on the active centers of the metal. The inhibition efficiencies of some aliphatic sulphides in ammonium chloride solution have been studied by...

Synthesis and Characterization of D-Lyxono-γ-lactone

D-lyxono-γ-lactone has been prepared in two steps from galactose. The first step potassium lyxonate was obtained in 64% yield and the title compound has been isolated in next step with 75% yield. The structures of the products were characterized by IR, 1H, 13C, mass and microanalysis study.

Synthesis and Study of Some Newer Analogues ofQuinolin-8-ol as Potent Antimicrobial Agents

New series of 4-(substituted phenyl)-5-[(quinolin-8-yloxy) methyl]-4H-1,2,4-triazole-3-thiol (4a-c), N³-(4-substituted phenyl)-5-[(quinolin-8-yloxy) methyl]-4H-1,2,4-triazole-3,4-diamine (5a-c) and N-(4-substituted phenyl)-5-[(quinolin-8-yloxy) methyl]-1,3,4-thiadiazol-2-amine (6a-g) have been synthesized and the structures of the new compounds were established on the basis of IR...

Development of RP-HPLC Method for the Estimation of Rabeprazole in Pure and Tablet Dosage Form

A simple, rapid, sensitive and precise High Performance Liquid Chromatographic (HPLC) method has been developed for the estimation of rabeprazole in bulk and tablet dosage form. In this method RP-C18 column (150 mm x 4.6 mm I.D, 5 µ m particle size) with mobile phase consisting of methanol and water in the ratio of 65:35 v/v in isocratic mode was used. The detection wavelength is...

Design, Synthesis and Evaluation of Schiff’s Bases of 4-Chloro-3-coumarin aldehyde as Antimicrobial Agents

4-Chloro-2-oxo-2H-chromene-3-carbaldehyde (2) was reacted with different anilines in rectified spirit as solvent to yield a series of the title compounds i.e. 4-chloro-3-((substituted-phenylimino) methyl)-2H-chromen-2-one (3a-i). These compounds were charaterised on the basis of their spectral (IR, 1H NMR) data and evaluated for antimicrobial activity in vitro against gram...

Antimicrobial Evaluation and Synthesis of Some Phenylpyrazolo benzothiazolo quinoxaline Derivatives

2,3-Diphenyl quinoxaline (SI) was fused with 2-amino benzothiazoles (SII) by a methylene bridge, which was then allowed for acetylation. The acetylated product (SIV) was made to react with different aromatic aldehydes to give chalcones (SV1-SV5). Chalcones refluxed with substituted acid hydrazides to afford different phenyl pyrazolo benzothiazolo quinoxaline derivatives (SVI1...

Mining the Information for Structure Based Drug Designing by Relational Database Management Notion

Structure based drug design is a technique that is used in the initial stages of a drug discovery program. The role of various computational methods in the characterization of the chemical properties and behavior of molecular systems is discussed. The field of bioinformatics has become a major part of the drug discovery pipeline playing a key role for validating drug targets. By...

Simple UV Spectrophotometric Method for the Determination of Fluvastatin Sodium in Bulk and Pharmaceutical Formulations

A simple and cost effective spectrophotometric method is described for the determination of fluvastatin sodium in pure form and in pharmaceutical formulations. When the drug reacts with sodium hydroxide shows absorption maximum at 304 nm and obeys beer's law in the concentration range 5-25 µg mL-1. The absorbance was found to increase linearly with increasing concentration of FVS...

Studies of Hydrogen Bonding Between N, N-Dimethylacetamide and Primary Alcohols

Hydrogen bonding between N, N-dimethylacetamide (DMA) and alcohols has been studied in carbon tetrachloride solution by an X-band Microwave bench at 936GHz. The dielectric relaxation time (τ) of the binary system are obtained by both Higasi's method and Gopalakrishna method. The most likely association complex between alcohol and DMA is 1:1 stoichiometric complex through the...

Rapid, Sensitive and Validated Ultra-Performance Liquid Chromatography/Mass Spectrometric Method for the Determination of Fenofibric Acid and its Application to Human Pharmacokinetic Study

The first, rapid and sensitive ultra performance liquid chromatography mass spectrometric method for the determination of fenofibric acid, the active metabolite of fenofibrate, a lipid regulating agent, in human EDTA plasma has been developed and validated using fenofibric d6 acid as internal standard and Waters LC-MS/MS. Negative ions of fenofibric acid and fenofibric d6 acid...

Isolation, Characterization and Antibacterial Activity Screening of Anthocyanidine Glycosides from Alchornea Cordifolia (Schumach. and Thonn.) Mull. Arg. Leaves

From the ethanolic extract of the leaves of Alchornea cordifolia (Schumach. and Thonn.) Mull. Arg,, 5–methyl 4’ -propenoxy anthocyanidines 7-O-β-D – diglucopyranoside was isolated. The structure was elucidated using NMR spectroscopy in combination with IR and MS spectral data. Antibacterial studies showed that the isolated compound successfully inhibited Pseudomonas aerguinosa...

Simple UV Spectrophotometric Determination of Duloxetine Hydrochloride in Bulk and in Pharmaceutical Formulations

A new, simple and sensitive spectrophotometric method in ultraviolet region has been developed for the determination of duloxetine hydrochloride in bulk and in pharmaceutical formulations. Duloxetine hydrochloride exhibits absorption maxima at 288 nm with apparent molar absorptivity of 0.97x104 L/mol.cm in 0.1 N HCL. Beer's law was found to be obeyed in the concentration range of...

Crystalline and Molecular Structure of Hexaaqua-1,3-diammoniumpropane Cobalt(II) Nitrate, Co(H2O) 6 [C3H12N2] (NO3)4

Chemical preparation and x-ray characterization of a new compound hexaaqua-1,3-diammoniumpropane cobalt(II) nitrate, Co(H2O) 6 [C3H12N2] (NO3)4 are reported. This mixed organo-mineral compound crystallizes in the orthorhombic system with Cmcm space group. The unit cell dimensions are: a = 10.795(7), b = 11.969(4), c = 14.685(5) Å, Z = 4 and V = 1897.5(12) Å3. The structure was...

A Green Solventless Protocol for the Synthesis of β-Enaminones and β-Enamino Esters Using Silica Sulfuric Acid as a Highly Efficient, Heterogeneous and Reusable Catalyst

Silica sulfuric acid is utilized as a green, highly efficient, heterogeneous and recyclable catalyst for the preparation of β-enaminones and β-enamino esters from amines and β-dicarbonyl compounds under solvent-free conditions at 80 °C. Using this method, the title compounds are produced in high to excellent yields and in short reaction times.

Evaluation of Some Tree Species to Absorb Air Pollutants in Three Industrial Locations of South Bengaluru, India

With the fast growing and excessive increase in industrial projects in Bengaluru, the level of pollution is also increasing. Metal-accumulating woody species have been considered for phytoextraction of metal-contaminated sites. The study examined the air pollution tolerance indices (APTI) of plant species around three industrial areas of south Bengaluru. The physiological and...

Synthesis, Spectral and Magnetic Studies of Newly Mixed-Ligand Complexes of 4-Formyl-Acetanilide Thiosemicarbazone and 3,4-Dihydrocinnamic Acid with Some Metal Ions

New complexes with thiosemicarbazone derivative and 3, 4-dihydrocinnamic acid were prepared and characterized by elemental analysis, determination of metal, IR, 1H NMR, electronic spectroscopy and magnetic measurements. The thiosemicarbazone derivative forms bidentate ligand complexes of the general formula, [M(Thz)(Caf)] where Thz = 4-formyl- acetanilide thiosemicarbazone, Caf...