American Journal of Clinical Pathology

https://academic.oup.com/ajcp

List of Papers (Total 5,620)

Determination of age-dependent bone marrow normocellularity

Determination of bone marrow cellularity is a key part of bone marrow examination because it provides a small window into a patient’s current state of hematopoietic well-being. Traditionally, bone marrow cellularity is estimated semiquantitatively through microscopic examination of core biopsy specimens harvested from the iliac crest of the pelvic bone. Bone marrow cellularity is...

A tip-predominant distribution of villous intraepithelial lymphocytes is not specific to celiac disease in children with Marsh I lesions

To assess if the distribution of villous intraepithelial lymphocytes (IELs) in a pediatric cohort with Marsh I histopathology is specific to celiac disease (CeD).

International health initiative: Development and pilot testing of a molecular diagnostics training program in Romania

The implementation of nucleic acid testing in laboratory medicine has revolutionized clinical diagnosis. Unfortunately, incorporation of these technologies in less developed countries remains a challenge. Despite Romania’s recent economic growth, the country is in dire need of medical and laboratory staff trained in modern technologies. The aim of the study was to develop a...

Development and validation of a standardized blood culture contamination definition and metric dashboard for a large health care system

Blood culture contamination is a major problem in health care, with significant impacts on both patient safety and cost. Initiatives to reduce blood culture contamination require a reliable, consistent metric to track the success of interventions. The objective of our project was to establish a standardized definition of blood culture contamination suitable for use in a Veterans...

Patterns of Major Frozen Section Interpretation Error: An In-Depth Analysis From a Complex Academic Surgical Pathology Practice

To establish baseline error rates due to misinterpretation and to identify scenarios in which major errors were most common and potentially preventable.

Changes in Coagulation Testing During a National Shortage of Blue-Top TubesA Laboratory Stewardship Opportunity

Manufacturer recalls and altered supply chains during the coronavirus disease 2019 (COVID-19) pandemic caused a nationwide shortage of blue-top tubes (BTTs). Most non–point-of-care coagulation tests use these tubes, leaving laboratories and health care facilities in short supply. The Department of Pathology and Laboratory Medicine at Cedars-Sinai Medical Center implemented...

A National Survey of Outpatient Platelet Transfusion Practice

Platelets are a limited resource frequently subject to inventory shortages. It benefits all to transfuse judiciously, according to evidence-based guidelines. Several organizations have published recommendations for platelet transfusions, but none specifically focused on outpatients. The Clinical Hemotherapy subsection of the Association for the Advancement of Blood & Biotherapies...

CD177 Enhances the Detection of Myelodysplastic Syndrome by Flow Cytometry

Previously we demonstrated that a decreased percentage of CD177-positive granulocytes detected by flow cytometry (FCM) was associated with myelodysplastic syndrome (MDS). Here we expand on those findings to more rigorously evaluate the utility of CD177 for the detection of MDS.

The Importance of Genetics Experts in Optimizing Genetic Test Orders Through Prospective and Retrospective Reviews

To demonstrate the impact of genetics specialists on identifying test order errors and improving reimbursement for genetic testing.

Increased High-Risk Human Papillomavirus Viral Load Is Associated With Immunosuppressed Microenvironment and Predicts a Worse Long-Term Survival in Cervical Cancer Patients

To evaluate the correlation between tumor-infiltrating lymphocytes (TILs) and the viral load of high-risk human papillomavirus (HR-HPV) in cervical cancer patients.

The American Society for Clinical Pathology’s Job Satisfaction, Well-Being, and Burnout Survey of Laboratory Professionals

To examine job satisfaction, well-being, job stress, and burnout among laboratory professionals.

The American Society for Clinical Pathology’s Job Satisfaction, Well-Being, and Burnout Survey of Pathologists

To examine job satisfaction, well-being, job stress, and burnout among pathologists.

Well-Being, Burnout, and the Clinical Laboratory

Burnout of health care professionals describes a combination of emotional exhaustion, depersonalization, and loss of sense of personal accomplishment.1 It is no

Three Emerging Coronaviruses in Two DecadesThe Story of SARS, MERS, and Now COVID-19

In the past two decades, the world has seen three coronaviruses emerge and cause outbreaks that have caused considerable global health consternation. Coronaviru

Corrigendum

Toward Improving Practices for Submission of Diagnostic Tissue Blocks for National Cancer Institute Clinical Trials

The National Cancer Institute (NCI) National Clinical Trials Network performs phase II and III clinical trials, which increasingly rely on the submission of diagnostic formalin-fixed, paraffin-embedded tissue blocks for biomarker assessment. Simultaneously, advances in precision oncology require that clinical centers maintain diagnostic specimens for ancillary, standard-of-care...

Repeat Biomarker Status in Breast Resection Specimens With Controlled Cold Ischemic Time

Current College of American Pathologists/American Society of Clinical Oncology guidelines recommend cold ischemic time (CIT) of 1 hour or less for breast specimens to preserve biomarker expression, although some publications support an acceptable CIT of 4 hours or less. We retrospectively evaluated changes in estrogen receptor (ER), progesterone receptor (PR), and human epidermal...

Resolution of HCV-Autoimmune Hepatitis Overlap Syndrome With Antiviral TreatmentA Paired Liver Biopsy StudyA Paired Liver Biopsy Study

To evaluate histologic changes occurring in patients having chronic hepatitis C and autoimmune hepatitis overlap (HCV-AIH), and who achieved virologic cure using direct-acting antiviral agents (DAA).

Clinical Referral Laboratory Personnel’s Perception of Challenges and Strategies for Sustaining the Laboratory Quality Management SystemA Qualitative Study in Rwanda

To explore challenges explaining the decrease in quality performance and suggest strategies to improve and sustain laboratory quality services.

The Utility of Phosphohistone H3 (PHH3) in Follicular Lymphoma Grading: A Comparative Study With Ki-67 and H&E Mitotic Count

To determine the utility of phosphohistone H3 (PHH3) mitotic count (MC) in grading follicular lymphoma (FL).

Radiofrequency Interference in the Clinical LaboratoryCase Report and Review of the Literature

Radiofrequency interference (RFI) is a known medical device safety issue, but there are no documented cases of interference resulting in erroneous laboratory results.